[1]张炜,韩彪△,刘喜平,等.补阳还五汤对60Coγ射线辐射损伤小鼠外周血T淋巴细胞亚群和IL-2的影响*[J].西部中医药,2014,27(01):17-19.
　ZHANG Wei,HAN Biao,LIU Xiping,et al.The Influence of BuYang HuanWu Tang on T Lymphocytes and IL-2 in Peripheral Blood of Mice Damaged by 60Co γ Ray Radiation[J].Western Journal of Traditional Chinese Medicine,2014,27(01):17-19.
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补阳还五汤对60Coγ射线辐射损伤小鼠外周血T淋巴细胞亚群和IL-2的影响*
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
27
期数:
2014年01期
页码:
17-19
栏目:
出版日期:
2014-01-14

文章信息/Info

Title:
The Influence of BuYang HuanWu Tang on T Lymphocytes and IL-2 in Peripheral Blood of Mice Damaged by 60Co γ Ray Radiation
文章编号:
1004-6852(2014)01-0017-03
作者:
张炜1，韩彪1△，刘喜平2，孙少伯3
1 兰州大学第一医院，甘肃 兰州730000； 2 兰州大学第一医院； 2 甘肃中医学院教育部“敦煌医学与转化”重点实验室； 3 甘肃中医学院中西医结合研究所
Author(s):
ZHANG Wei1, HAN Biao1△, LIU Xiping2, SUN Shaobo3
1 Lanzhou University the First Hospital, Lanzhou 73000, China; 2 Key Laboratory of Education Ministry ″Dunhuang Medicine and Translation″ from Gansu University of Traditional Chinese Medicine; 3 Institute of Integrative Medicine of Gansu University of Traditional Chinese Medicine;
关键词:
补阳还五汤; 60Coγ射线; 辐射损伤; 小鼠
Keywords:
BuYang HuanWu Tang;  60Coγ ray;  damaged by radiation;  mice
分类号:
R392.12
文献标志码:
A
摘要:
目的：探讨补阳还五汤对辐射损伤的防护作用及机制。方法：采用60Coγ射线对小鼠进行一次性全身照射致辐射损伤动物模型,观察外周血淋巴细胞亚群CD3+、CD4+、CD8+及白细胞介素-2(IL-2)的变化。结果：于60Coγ射线照射前后,连续14天灌胃补阳还五汤水煎液，可使受辐射小鼠外周血的CD3+和CD4+水平显著上升(P＜0.01)，同时可升高血清及脾脏白细胞介素-2(IL-2)水平。结论：补阳还五汤具有明显的抗辐射作用，其机制可能与其能增强机体免疫功能，减轻辐射对机体的损伤，调整免疫系统功能恢复，增强机体对辐射的抵御力有关。
Abstract:
Objective: To explore the protection and the mechanism of BuYang HuanWu Tang for radiation damage. Methods: Animal model was established through 60Coγ ray total body radiation once. The changes of interleukin -2 (IL-2) and T lymphocytes in peripheral blood including CD3+, CD4+, CD8+ were observed. Results: Before and after 60Coγ ray radiation, BuYang HuanWu Tang was given by intragastric administration for 14 days, which could make the levels of CD3+ and CD4+ rise in peripheral blood of the mice significantly (P＜0.01), and raise the level of IL-2 in the serum and the spleen. Conclusion: BuYang HuanWu Tang is effective in protecting the mice with radiation damage, and the mechanism might be related to enhancing immunologic function of the body, relieving the damage caused by radiation of the body, regulating functional recovery of immunologic function and improving animal resistance to the radiation.

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备注/Memo

备注/Memo:
收稿日期：2013-04-27*基金项目：甘肃省中医药科研项目(编号GZK-2011-79)作者简介：张炜(1977—)，男，硕士研究生，主治医师。研究方向：心胸外科疾病的中西医结合诊治。△通讯作者：韩彪(1966—)，男，硕士研究生导师，教授。研究方向：胸外科疾病的诊治。
更新日期/Last Update: 2014-01-15