[1]周立亚,刘德玉,李福林,等.热敷散外敷治疗兔骨性关节炎的机理研究[J].西部中医药,2014,27(10):22.
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热敷散外敷治疗兔骨性关节炎的机理研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
27
期数:
2014年10期
页码:
22
栏目:
出版日期:
2014-10-15

文章信息/Info

作者:
周立亚1，刘德玉2，李福林3，邹季1
1 湖北中医药大学针灸骨伤学院，湖北 武汉 430000； 2 陕西中医学院附属医院骨科；3 榆林市卫生学校附属医院
关键词:
骨关节炎; 热敷散; 白介素-β1; 肿瘤坏死因子-α
摘要:
目的：观察中药热敷散外敷治疗兔骨性关节炎模型的组织病理学变化及关节冲洗液中白介素-β1(IL-β1)与肿瘤坏死因子-α(TNF-α)的变化，探讨热敷散对兔骨性关节炎的疗效及其作用机理。方法：采用兔膝关节腔内注射木瓜蛋白酶的方法，建立兔骨性关节炎模型：将30只日本大耳白兔随机分为空白对照组(A组，n=10)、模型对照组(B组，n=10)、热敷散组(C组，n=10)。造模后1周，在3组动物中各随机抽取1只实验动物，空气栓塞法处死后进行患膝关节病理观察，明确造模是否成功。A组每天热水袋热敷膝关节2次；B组造模成功后每天热水袋热敷膝关节2次；C组造模成功后，每天用热敷散热敷治疗2次。在治疗4周后，空气栓塞法处死动物，抽取膝关节液后，切开兔的膝关节，观察膝关节股骨髁关节面大体病理变化及股骨髁关节软骨病理变化，并检测关节冲洗液中IL-β1与TNF-α含量的变化。结果：①在造模成功，给予3组实验动物相应治疗4周后处死实验动物，抽取膝关节液后，做病理观察见A组动物关节及关节软骨正常；B、C组动物关节肿胀，关节软骨面破坏。②B、C组动物关节冲洗液中IL-β1和TNF-α的含量明显高于A组(P＜0.05)，同时C组动物关节冲洗液中IL-β1和TNF-α的含量明显低于B组(P＜0.05)。结论：热敷散能通过降低关节液中IL-β1和TNF-α的含量进而起到对骨关节炎的治疗作用。

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备注/Memo

备注/Memo:
作者简介：周立亚(1976—)，男，博士研究生，副主任医师。研究方向：脊椎、关节疾病的中西医结合诊治。
更新日期/Last Update: 2014-10-15