[1]奚骏,陈建杰△.芪芩汤联合拉米夫定治疗慢性乙型病毒性肝炎的临床疗效[J].西部中医药,2016,29(07):99-101.
　XI Jun,CHEN Jianjie.Curative Effects of QiQin Tang Combined with Lamivudine in Treating Chronic Viral Hepatitis B[J].Western Journal of Traditional Chinese Medicine,2016,29(07):99-101.
点击复制

芪芩汤联合拉米夫定治疗慢性乙型病毒性肝炎的临床疗效
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
29
期数:
2016年07期
页码:
99-101
栏目:
出版日期:
2016-07-15

文章信息/Info

Title:
Curative Effects of QiQin Tang Combined with Lamivudine in Treating Chronic Viral Hepatitis B
文章编号:
1004-6852(2016)07-0099-03
作者:
奚骏，陈建杰△
上海浦东新区传染病医院，上海 201299
Author(s):
XI Jun, CHEN Jianjie△
Infectious Disease Hospital of Pudong New District, Shanghai 201299, China
关键词:
慢性乙型肝炎; 芪芩汤; 拉米夫定
Keywords:
chronic viral hepatitis B;  QiQin Tang;  lamivudine
分类号:
R442.5
文献标志码:
B
摘要:
目的：观察芪芩汤联合拉米夫定治疗慢性乙型病毒性肝炎的临床疗效。方法：将乙肝病毒HBV-DNA阳性且中医辨证为肝郁脾虚兼湿热证的慢性乙型肝炎患者70例随机分为治疗组及对照组各35例。对照组予拉米夫定100 mg，1次/d，口服，治疗组在对照组治疗的基础上加用芪芩汤，1剂/d，水煎200 mL，分2次口服，1年后观察疗效。结果：1年后拉米夫定耐药率治疗组、对照组分别为11.43%、31.43%，2组比较差异有统计学意义（P＜0.05）；治疗6个月后，治疗组血清HBV-DNA转阴率为77.14%，高于对照组的54.29%(P＜0.05)。治疗组ALT、AST较对照组恢复更显著(P＜0.05)。中药对改善口干苦、肝区胀痛、脘腹痞胀、溲黄、舌苔方面明显优于对照组，2组总有效率比较有显著性差异(P＜0.01)。结论：与单独应用拉米夫定比较，芪芩汤联合拉米夫定治疗中医辨证为肝郁脾虚兼湿热型慢性乙型肝炎患者，有更理想的疗效，能有效降低拉米夫定耐药率，抑制HBV-DNA复制，改善肝功能及临床症状。
Abstract:
Objective: To investigate curative effects of QiQin Tang combined with lamivudine in treating chronic viral hepatitis B. Methods: Seventy patients proved with positive HBV-DNA and differentiated as liver-Qi stagnation and spleen deficiency complicated with heat-dampness pattern were randomly allocated to the treatment group and the control group. The control group took lamivudine, 100 mg, once per day, oral administration, and the treatment group accepted QiQin Tang, one dose per day, decocted to 200 mL, taking for twice orally, clinical effects were observed in one year. Results: Lamivudine resistant rates of the treatment group and the control group were 11.43% and 31.43% respectively in one year (P＜0.05); after treating in six months, serum HBV-DNA negative conversion rate of the treatment group was 77.14%, higher than 54.29% of the control group (P＜0.05). ALT and AST of the treatment group were more significant compared with these of the control group(P＜0.05). The treatment group was superior to the control group in herbs improving dry and bitter mouth, liver area pain, abdominal distension, yellow urine, and tongue fur, the difference had statistical difference in the comparisons of total effective rate (P＜0.01). Conclusion: Compared with using lamivudine only, QiQin Tang combined with lamivudine could obtain satisfactory effects in treating the patients with chronic viral hepatitis B of liver-Qi stagnation and spleen deficiency complicated with heat-dampness pattern, the therapy could effectively decrease lamivudine resistant rate, inhibit HBV-DNA replication, improve liver function and clinical effects.

相似文献/References:

[1]章淑萍,杨姒姚,邓志文,等.香丹穴位注射对慢性乙型肝炎疗效的影响[J].西部中医药,2015,28(11):115.
[2]丁然,陆小左△.慢性乙型肝炎中医证候与舌象客观量化指标相关性的临床研究*[J].西部中医药,2015,28(01):56.
[3]陆云飞,叶佩燕,孙剑勇,等.复方芪术汤联合替比夫定治疗慢性乙型肝炎临床疗效[J].西部中医药,2018,31(09):100.
　LU Yunfei,YE Peiyan,SUN Jianyong,et al.Curative Effects of Compound QiZhu Decoction Jointed with Tibivudine in Treating Chronic Hepatitis B[J].Western Journal of Traditional Chinese Medicine,2018,31(07):100.
[4]朱梦佳,蔡萌强,杨慧萍,等.小柴胡汤联合恩替卡韦治疗慢性乙型病毒性肝炎的Meta分析[J].西部中医药,2021,34(12):62.[doi:10.12174/j.issn.2096-9600.2021.12.17]
　ZHU Mengjia,CAI Mengqiang,YANG Huiping,et al.Meta Analysis of Xiaochaihu Decoction and Entecavir in the Treatment of Chronic Hepatitis B[J].Western Journal of Traditional Chinese Medicine,2021,34(07):62.[doi:10.12174/j.issn.2096-9600.2021.12.17]

备注/Memo

备注/Memo:
收稿日期：2015-09-02 *基金项目：上海浦东新区学科人才项目(编号PDZYXK- 6-2014012)。 作者简介：奚骏(1978—)，男，硕士学位，主治医师。研究方向：肝病、传染病的中医诊治。 △通讯作者：陈建杰(1952—)，男，博士研究生导师，硕士学位，主任医师，上海市名中医，上海市医学领军人才，欧洲肝病协会委员，中西医结合学会传染病专业委员会副主任委员，“国家医师奖”获得者。研究方向：肝病的中医诊治。
更新日期/Last Update: 2016-07-15