[1]解鑫隆,徐朝军△,尹晓清,等.醒脑静辅助奥氮平治疗主动脉夹层腔内隔绝术后谵妄45例[J].西部中医药,2018,31(10):79-82.
　XIE Xinlong,XU Chaojun,YIN Xiaoqing,et al.Treating 45 Cases of Delirium after the EVGE for Aortic Dissection by XingNaoJing Injection as AT and Olanzapine[J].Western Journal of Traditional Chinese Medicine,2018,31(10):79-82.
点击复制

醒脑静辅助奥氮平治疗主动脉夹层腔内隔绝术后谵妄45例()
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年10期
页码:
79-82
栏目:
出版日期:
2018-10-15

文章信息/Info

Title:
Treating 45 Cases of Delirium after the EVGE for Aortic Dissection by XingNaoJing Injection as AT and Olanzapine
文章编号:
1004-6852(2018)10-0079-04
作者:
解鑫隆，徐朝军△，尹晓清，王兆礼，杨进，程宇，张胜康
湖南中医药大学第一附属医院心胸外科，湖南 长沙 410007
Author(s):
XIE Xinlong, XU Chaojun△, YIN Xiaoqing, WANG Zhaoli, YANG Jin, CHENG Yu, ZHANG Shengkang
Department of Cardiothoracic Surgery, the First Hospital of Hunan University of Chinese Medicine, Changsha 410007, China
关键词:
谵妄; 主动脉夹层; 腔内隔绝术; 醒脑静注射液; 炎症因子
Keywords:
delirium;  aortic dissection;  EVGE;  XingNaoJing injection;  inflammatory factor
分类号:
R543.1
文献标志码:
B
摘要:
目的：观察醒脑静辅助奥氮平治疗Stanford B型主动脉夹层腔内隔绝术后谵妄患者的临床疗效。方法：将90例患者随机分为对照组和观察组，每组45例。2组在治疗原发病的基础上给予奥氮平，口服或鼻饲，1次/d。观察组同时给予静滴醒脑静注射液，1次/d，2组均连续治疗1周。比较2组谵妄持续时间、术后住院时间、合并症发生率、住院期间病死率、不良反应发生情况以及患者谵妄确诊时(T0)、治疗后24小时(T1)、治疗后48小时(T2)、治疗后76小时(T3)的 C反应蛋白(CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)水平。结果：谵妄持续时间、术后住院时间观察组均短于对照组(P＜0.05)，住院期间合并症发生率观察组低于对照组(P＜0.05)，住院期间病死率2组比较，差异无统计学意义(P＞0.05)。CRP、TNF-α、IL-6水平同组治疗后各时间节点较T0时显著降低(P＜0.05)，并随时间的推移呈下降趋势；治疗后各时间节点观察组较对照组下降明显(P＜0.05)。不良反应发生率2组比较，无明显差异。结论：醒脑静辅助奥氮平治疗Stanford B型主动脉夹层腔内隔绝术后谵妄的安全性及有效性方面均较单独使用奥氮平好。
Abstract:
Objective: To observe clinical effects of XingNaoJing injection as ajunctive therapy(AT) and olanzapine in treating postoperative delirium of the patients with stanford B type aortic dissection who underwent endovascular graft exclusion (EVGE). Methods: All 90 patients were randomized into the control group and the observation group, 45 cases each group. Both groups were given olanzapine by oral administration or nasal feeding on the basic treatment for primary disease, once each day. The observation group accepted intravenous dripping of XingNaoJing injection, once each day, both groups were treated for one week consecutively. Delirium duration, postoperative hospitalization times, the incidences of the complications, mortality rate during hospitalization period, the incidences of adverse reaction, and the levels of tumor growth factor α(TNF-α), interleukin6(IL-6) and C reactive protein(CRP) at the time when the patients were diagnosed as delirium(T0), in 24 hours after treating(T1), in 48 hours after treating(T2) and in 76 hours after treating(T3) were compared between both groups. Results: The observation group was shorter than the control group in delirium duration and postoperative hospitalization time(P＜0.05), the observation group was lower than the control group in the incidence of the complications during hospitalization period (P＜0.05), there was no obvious difference in the comparisons of mortality rate during hospitalization period between both groups (P＞0.05). The levels of CRP, TNF-α and IL-6 of the same group after treating at different times reduced remarkably compared with T0 (P＜0.05), they showed the decreasing tendency as the time went by; the decrease of the observation group was more obvious than that of the control group at different times after treating (P＜0.05). There were no obvious difference in the comparisons of the incidence of adverse reaction between both groups. Conclusion: The safety and effectiveness of XingNaoJing injection as AT and olanzapine are better than these of only olanzapine in treating postoperative delirium of the patients with Stanford B type aortic dissection who underwent EVGE.

相似文献/References:

[1]关新红,张长彪.老年髋部骨折谵妄护理的研究进展[J].西部中医药,2024,37(07):108.[doi:10.12174/j.issn.2096-9600.2024.07.25]
　GUAN Xinhong,ZHANG Changbiao.Delirium in Elderly Patients after Hip Fracture: Research Progress in Nursing[J].Western Journal of Traditional Chinese Medicine,2024,37(10):108.[doi:10.12174/j.issn.2096-9600.2024.07.25]

备注/Memo

备注/Memo:
收稿日期：2018-03-07 *基金项目：湖南省中医药科研计划项目（编号201696)；中医内科学省部共建教育部重点实验室开放基金支助项目（编号ZYNK201506)。 作者简介：解鑫隆(1983—)，男，硕士学位，主治医师。研究方向：主动脉疾病的中西医结合诊治。 △通讯作者：徐朝军(1974—)，男，博士学位，副主任医师。研究方向：外科疾病的中西医结合诊治。
更新日期/Last Update: 2018-08-15