[1]刘玉明,张丽华,张亚丽,等.参芪扶正注射液联合血必净治疗感染性休克临床疗效分析[J].西部中医药,2019,32(02):5-8.
　LIU Yuming,ZHANG Lihua,ZHANG Yali,et al.Clinical Effects Analysis of ShenQi FuZheng Injection Combined with XueBiJing in Treating Infectious Shock[J].Western Journal of Traditional Chinese Medicine,2019,32(02):5-8.
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参芪扶正注射液联合血必净治疗感染性休克临床疗效分析
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
32
期数:
2019年02期
页码:
5-8
栏目:
出版日期:
2019-02-15

文章信息/Info

Title:
Clinical Effects Analysis of ShenQi FuZheng Injection Combined with XueBiJing in Treating Infectious Shock
文章编号:
1004-6852(2019)02-0005-04
作者:
刘玉明，张丽华，张亚丽，李颖华，李桓，樊宏丹
华北石油管理局总医院，河北 任丘 062552
Author(s):
LIU Yuming，ZHANG Lihua，ZHANG Yali，LI Yinghua，LI Huan，FAN Hongdan
North China Petroleum Administration Bureau General Hospital, Renqiu 062552, China
关键词:
休克; 感染性; 参芪扶正注射液; 血必净注射液
Keywords:
shock;  infectious;  ShenQi FuZheng injection;  XueBiJing injection
分类号:
R631+.4
摘要:
目的：分析参芪扶正注射液联合血必净治疗感染性休克的临床疗效，并评价其安全性。方法：选取就诊的120例感染性休克患者随机分为对照组和观察组，每组60例。对照组给予常规抗感染及对症治疗，观察组在对照组治疗方案基础上加用参芪扶正注射液和血必净注射液，2组疗程均为5天。观察并比较2组患者临床疗效，危重疾病严重程度评分(APACHE Ⅱ)及序贯器官衰竭评分(SOFA)，复苏液体用量、缩血管药物用量、肢体水肿发生率，机械通气时间、住ICU时间、28天病死率，血流动力学指标，血清炎症细胞因子水平。结果：总有效率观察组高于对照组，差异有统计学意义(P＜0.05)；APACHE Ⅱ评分、SOFA评分治疗后2组均降低，差异有统计学意义(P＜0.05)，且观察组较对照组降低更明显，差异有统计学意义(P＜0.05)；复苏液体用量、缩血管药物用量和肢体水肿发生率观察组均低于对照组，差异均有统计学意义(P＜0.05)，机械通气时间和住ICU时间观察组均短于对照组，差异有统计学意义(P＜0.05)，28天病死率2组比较差异无统计学意义(P＞0.05)；治疗后血流动力学指标2组均明显改善，其中观察组心排血量指数、体循环血管阻力指数较对照组显著升高、心率(HR)显著降低(P＜0.05)，差异均有统计学意义(P＜0.05)，平均动脉压、肺血管楔压、混合静脉血氧饱和度2组比较，差异无统计学意义(P＞0.05)；治疗后C反应蛋白、血清降钙素原及肿瘤坏死因子α水平2组均显著降低，差异有统计学意义(P＜0.05)，且观察组降低较对照组明显(P＜0.05)；2组治疗期间均未见明显不良反应。结论：参芪扶正注射液联合血必净治疗感染性休克临床疗效显著，安全可靠。
Abstract:
Objective：To analyze clinical effects of ShenQi FuZheng injection combined with XueBiJing in treating infectious shock, and assess its safety. Methods: All 120 patients were randomized into the control group and the observation group, 60 cases each group. The control group were given conventional anti-inflammation and symptomatic treatment, and the observation group accepted ShenQi FuZheng injection combined with XueBiJing on the foundation of therapeutic regimen the control group received, the course was five days. The levels of inflammatory cytokines, hemodynamic indexes, 28-day mortality, the time of staying at ICU, mechanical ventilation time, the incidence of limb edema, the dose of vasoconstrictor, the dose of fliud resuscitation, sequential organ failure assessment(SOFA), acute physiology and chronic health evaluation Ⅱ(APACHEⅡ) and clinical effects were observed and compared between both groups. Results: Total effective rate of the observation group was higher than that of the control group, and the difference had statistical meaning(P＜0.05); APACHE Ⅱ scores and SOFA scores of both groups decreased after treating, and the difference had statistical meaning(P＜0.05), and the decrease of the observation group was more obvious than that of the control group, and the difference showed statistical meaning(P＜0.05); the observation group was lower than the control group in the dose of fliud resuscitation, the incidence of limb edema and the dose of vasoconstrictor, and the difference showed statistical meaning(P＜0.05), the observation group was shorter than the control group in mechanical ventilation time and the time of staying at ICU, and the difference showed statistical meaning(P＜0.05), the difference had no statistical meaning in the comparisons of 28-day mortality between both groups(P＞0.05); hemodynamic indexes of both groups after treating improved notably, cardiac output index and systemic vascular resistance index of the observation group rose notably compared with the control group, heart rate(HR) lowered signficantly (P＜0.05), and the difference showed statistical meaning(P＜0.05). The difference had no statistical meaning in the comparisons of mean arterial pressure(MAP), pulmonary artery wedge pressure and mixed venous oxygen saturation between both groups(P＞0.05); after treating, the levels of CRP, serum procalcitonin and TNF-α of both groups lowered notably, and the difference showed statistical meaning (P＜0.05), and the decrease of the observation group was more notable than the control group(P＜0.05). No obvious adverse reaction happened in both groups during therapeutic period. Conclusion: ShenQi FuZheng injection combined with XueBiJing could obtain notable effects in treating infectious shock, which is safe and reliable.

备注/Memo

备注/Memo:
收稿日期：2018-07-15 *基金项目：河北省自然科学基金资助项目(编号2016-1935)。 作者简介：刘玉明(1973—)，男，硕士学位。研究方向：普外科疾病的诊治。
更新日期/Last Update: 2019-02-15