[1]李运,邱国玉△,石晓峰,等.关黄柏饮片标准汤剂的质量标准研究[J].西部中医药,2019,32(07):43-48.
　LI Yun,QIU Guoyu,SHI Xiaofeng,et al.Quality Standard of Guanhuangbo Standard Decoction[J].Western Journal of Traditional Chinese Medicine,2019,32(07):43-48.
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关黄柏饮片标准汤剂的质量标准研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
32
期数:
2019年07期
页码:
43-48
栏目:
出版日期:
2019-07-15

文章信息/Info

Title:
Quality Standard of Guanhuangbo Standard Decoction
文章编号:
1004-6852(2019)07-0043-06
作者:
李运1，邱国玉1△，石晓峰1，2，李志俊1，徐雪梅1
1 兰州市食品药品检验所，甘肃 兰州 730030； 2 甘肃省医学科学研究院
Author(s):
LI Yun1, QIU Guoyu1△, SHI Xiaofeng1, 2, LI Zhijun1, XU Xuemei1
1 Lanzhou Institute for Food and Drug Control, Lanzhou 730030, China;2 Gansu Provincial Academy of Medical Sciences
关键词:
关黄柏; 标准汤剂; 质量标准; HPLC; 指纹图谱
Keywords:
Guanghuangbo;  standard decoction;  quality standard;  HPLC;  fingerprint
分类号:
R284.1
文献标志码:
A
摘要:
目的：建立关黄柏标准汤剂的质量控制方法。方法：收集具有代表性的10批关黄柏饮片，参照标准，制备标准汤剂。以盐酸巴马汀和盐酸小檗碱为定量检测指标，计算二者平均转移率与出膏率，并建立其HPLC指纹图谱分析方法。结果：对10批关黄柏饮片标准汤剂进行含量测定，指标成分的平均转移率为51.3%～65.9%，出膏率为17.3%～20.4%；并利用中药色谱指纹图谱相似度评价系统软件(2012版)进行分析，标定了10个共有峰，确认了其中3个峰，分别为盐酸药根碱、盐酸巴马汀、盐酸小檗碱；指纹图谱相似度均大于0.95。结论：建立了系统评价关黄柏饮片标准汤剂的质量评价方法，可为源于关黄柏水煎液的相关制剂的质量控制标准的制定提供参考。
Abstract:
Objective: To establish the methods for quality control of Guanhuangbo(phellodendri amurensis cortex) standard decoction. Methods: Ten batches of typical Guanhuangbo decoction pieces were collected and prepared into standard decoction in light of the preparation standard. Palmatine hydrochloric acid and berberine hydrochloride were chosen as the indexes of quantitative detection, to calculate average transfer rate and extraction rate, and establish HPLC fingerprint analysis methods for both indexes. Results: By determining the contents of ten batches of Guanghuangbo, average transfer rate of the index components was ranged from 51.3% to 65.9%, extraction rates was from 17.3% to 20.4%; the similarity evaluation system for herbal chromatographic fingerprint (edition 2012) was utilized to analyze, ten common peaks were determined, three were identified as root base hydrochloric acid, palmatine hydrochloric acid and berberine hydrochloride; the similarity of fingerprints were higher than 0.95. Conclusion: The quality evaluation method to assess Guanghuangbo standard decoction systematically is established, and it could provide the reference for establishing quality standard of Guanghuangbo related decoction.

相似文献/References:

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　ZHANG Shihua,NI Lin,GUO Zhaohui,et al.A Correlational Analysis of the Contents of Active Ingredients and the Extract of Guanghuangbo and Its Appearance and Color[J].Western Journal of Traditional Chinese Medicine,2024,37(07):15.[doi:10.12174/j.issn.2096-9600.2024.10.04]
[2]高晗,孙福仁,李争,等.基于Fisher判别分析的槐花、炒槐花标准汤剂特征图谱差异性研究[J].西部中医药,2025,38(01):11.[doi:10.12174/j.issn.2096-9600.2025.01.03]
　GAO Han,SUN Furen,LI Zheng,et al.Study on the Differences of the Characteristic Mapping of Standard Decoction of Huaihua and Fried Huaihua Based on Fisher Discriminant Analysis[J].Western Journal of Traditional Chinese Medicine,2025,38(07):11.[doi:10.12174/j.issn.2096-9600.2025.01.03]

备注/Memo

备注/Memo:
收稿日期：2018-02-27作者简介：李运(1985—)，男，硕士学位，工程师。研究方向：药用植物资源开发与利用。△通讯作者：邱国玉(1971—)，男，硕士学位，高级工程师。研究方向：中药质量控制。
更新日期/Last Update: 2019-07-15