[1]张哲,陆玉兰,王燕.中西医结合治疗多囊卵巢综合征85例[J].西部中医药,2020,33(02):103-106.[doi:10.12174/j.issn.1004-6852.2020.02.29]
　ZHANG Zhe,LU Yulan,WANG Yan.Integrative Medicine in the Treatment for 85 PCOS Patients[J].Western Journal of Traditional Chinese Medicine,2020,33(02):103-106.[doi:10.12174/j.issn.1004-6852.2020.02.29]
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中西医结合治疗多囊卵巢综合征85例
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
33
期数:
2020年02期
页码:
103-106
栏目:
出版日期:
2020-02-15

文章信息/Info

Title:
Integrative Medicine in the Treatment for 85 PCOS Patients
文章编号:
1004-6852(2020)02-0103-04
作者:
张哲，陆玉兰，王燕
上海市奉贤中心医院，上海 201499
Author(s):
ZHANG Zhe, LU Yulan, WANG Yan
Shanghai Fengxian District Central Hospital, Shanghai 201499, China
关键词:
多囊卵巢综合征; 桂枝茯苓丸; 克罗米芬; 慢性炎症; 氧化应激
Keywords:
PCOS;  Guizhi Fuling pills;  clomiphene;  chronic inflammation;  oxidative stress
分类号:
R711.75
DOI:
10.12174/j.issn.1004-6852.2020.02.29
摘要:
目的：观察桂枝茯苓丸联合克罗米芬治疗多囊卵巢综合征的临床疗效及其对机体慢性炎症和氧化应激的影响。方法：将170例患者根据随机数字法分为观察组和对照组，每组85例。对照组予以克罗米芬治疗，50 mg/次，每日1次，自月经周期第5天开始口服，连服5天。观察组在对照组治疗的基础上服用桂枝茯苓丸，6 g/次，每日2次，月经期停止口服。两组均治疗3个月经周期。观察两组治疗后子宫内膜厚度、宫颈黏液评分、卵泡大小、成熟卵泡个数、月经量评分和排卵比率；观察两组治疗前后雌激素(E2)、睾酮(T)、促黄体生成素(luteinizing hormone，LH)、促卵泡生成素(follicle stimulating hormone，FSH)、白细胞介素18(interleukin-18，IL-18)、白细胞介素6（interleukin-6，IL-6）、单核细胞趋化蛋白1(monocyte chemoatt-ractant protein 1，MCP-1)、总抗氧化能力(total antioxidant capacity，T-AOC)、超氧化物歧化酶(super-oxide dismutase,SOD)、过氧化氢酶(catalase，CAT)和谷胱甘肽过氧化物酶(Glutathione catalase，GSH-Px)水平的变化情况。结果：总有效率观察组为85.88%（73/85），对照组为71.76%（61/85），两组比较差异有统计学意义(P＜0.05)。观察组子宫内膜厚度、宫颈黏液评分、卵泡大小、成熟卵泡个数和排卵比率明显高于或者多于对照组，观察组月经量评分明显低于对照组，差异均有统计学意义(P＜0.05)。E2、T、LH、FSH、IL-18、IL-6、MCP-1、T-AOC、SOD、CAT、GSH-Px水平治疗前后两组组内比较，差异有统计学意义(P＜0.05)；治疗后组间比较差异也有统计学意义(P＜0.05)。结论：桂枝茯苓丸联合克罗米芬治疗PCOS疗效显著，这可能与桂枝茯苓丸减轻机体慢性炎症和氧化应激有关。
Abstract:
Objective: To observe clinical effects of Guizhi Fuling pills and clomiphene in the treatment for polycystic ovarian syndrome (PCOS) and its effects on chronic inflammation and oxidative stress of the patients. Methods: All 170 patients were randomized into the observation group and the control group according to random number method, 85 cases each group. The control group were given clomiphene, 50 mg each time, once each day, they began to take medicine since the fifth day of the menstrual period, for five days consecutively. The observation group took Guizhi Fuling pills based on the therapy the control group accepted, 6 g each time, twice each day, ceasing the medication during the period. Both groups were treated for three menstrual cycles. To observe endometrial thickness, cervical mucus scores, follicular size, the number of mature follicles, menstrual volume scores and ovulation ratio in both groups after treating; to observe the levels of estrogen (E2), testosterone (T), luteinizing hormone (LH), follicle stimulating hormone (FSH), IL-18, IL-6, monocyte chemoattractant protein 1 (MCP-1), total antioxidant capacity (T-AOC), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in both groups before and after treating. Results: Total effective rate of the observation group was 85.88% (73/85), higher than 71.76% (61/85) of the control group, and the difference had statistical meaning between both groups (P＜0.05). The observation group was hgher than or more than the control group in endometrial thickness, cervical mucus scores, follicular size, the number of mature follicles and ovulation ratio notably, and the observation group was lower than the control group in the scores of menstrual volume obviously, and the difference had statistical meaning (P＜0.05). The difference had statistical meaning in the levels of E2, T, LH, FSH, IL-18, IL-6, MCP-1, T-AOC, SOD, CAT and GSH-Px within two groups before and after treating (P＜0.05); the difference showed statistical meaning between both groups after treating (P＜0.05). Conclusion: Guizhi Fuling pills and clomiphene are effective in treating PCOS, and it might be related to that Guizhi Fuling pills could relieve chronic inflammation and oxidative stress.

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备注/Memo

备注/Memo:
收稿日期：2019-03-29作者简介：张哲(1986—)，男，药师。研究方向：不孕症及女性更年期综合征的中西医结合治疗。
更新日期/Last Update: 2020-02-15