[1]陈英,王娅.补肺活血化瘀法对COPD患者血清NO水平、血液流变学及生活质量的影响[J].西部中医药,2020,33(05):91-94.[doi:10.12174/j.issn.1004-6852.2020.05.26]
　CHEN Ying,WANG Ya.Effects of Lung-tonifying Blood-activating Stasis-removing Method on Quality of Life, NO Level and Hemorheology in COPD Patients[J].Western Journal of Traditional Chinese Medicine,2020,33(05):91-94.[doi:10.12174/j.issn.1004-6852.2020.05.26]
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补肺活血化瘀法对COPD患者血清NO水平、血液流变学及生活质量的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
33
期数:
2020年05期
页码:
91-94
栏目:
出版日期:
2020-05-15

文章信息/Info

Title:
Effects of Lung-tonifying Blood-activating Stasis-removing Method on Quality of Life, NO Level and Hemorheology in COPD Patients
文章编号:
1004-6852(2020)05-0091-04
作者:
陈英，王娅
商洛市中医医院内一科，陕西 商洛 726000
Author(s):
CHEN Ying, WANG Ya△
First Department of Internal Medicine, Shangluo City Hospital of TCM, Shangluo 726000, China
关键词:
慢性阻塞性肺疾病; 肺肾亏虚证; 一氧化氮; 血液流变学; 生活质量; 补肺活血化瘀法; 中医药
Keywords:
COPD;  lung-kidney deficiency pattern;  NO;  hemorheology;  quality of life;  lung-tonifying blood-activating stasis-removing method;  TCM
分类号:
R563
DOI:
10.12174/j.issn.1004-6852.2020.05.26
文献标志码:
B
摘要:
目的：探讨补肺活血化瘀法对慢性阻塞性肺疾病(chronic obstructive pulmonary disease，COPD)患者血清一氧化氮(nitric oxide，NO)水平、血液流变学及生活质量的影响。方法：采用随机数字表法将COPD肺肾亏虚证患者162例分为试验组、对照组各81例，对照组采用常规西医治疗；试验组在对照组基础上采用补肺活血化瘀法治疗。比较两组患者治疗前后血清NO、血液流变学指标［全血高切黏度（high blood viscosity，HBV）、全血低切黏度（low cutting viscosity，LCV）、纤维蛋白原（fibrinogen，FIB）、红细胞聚集指数（erythrocyte aggregation index，Arbc）、刚性指数（rigidity index，IR）］及生活质量；计算两组患者临床控制率及总有效率。结果：治疗后对照组患者HBV、LCV、FIB、Arbc、IR略下降，与治疗前比较差异无统计学意义(P＞0.05)，试验组各指标明显下降，且低于对照组(P＜0.05)；两组NO水平及呼吸症状、疾病影响、活动能力、SGRQ总评分均较治疗前下降(P＜0.05)，试验组下降更明显(P＜0.05)。试验组临床控制率为35.8%(29/81)，总有效率为98.8%(80/81)，分别高于对照组的17.3%(14/81)、84.0%(68/81)(P＜0.05)。结论：补肺活血化瘀法可改善COPD肺肾亏虚证患者临床症状、肺功能及血液高凝状态，能抑制NO合成释放，缓解炎症反应，提高患者生活质量。
Abstract:
Objective: To explore the effects of lung-tonifying blood-activating stasis-removing method on NO level, hemorheology and quality of life in COPD patients. Methods: All 162 patients were separated into the test group and the control group using random number table method, 81 cases each group, the control group adopted conventional Western medicine, the test group were treated by lung-tonifying blood-activating stasis-removing method based on conventional Western medicine. To compare NO, hemorheological indexes (HBV, LCV, FIB, Arbc and IR) and quality of life; calculate clinical control rate and total effective rate of the patients in both groups. Results: After treating, HBV, LCV, FIB, Arbc and IR of the control group reduced, the difference showed no statistical meaning when it was compared with before treating (P＞0.05), different indexes of the test group reduced notably, lower than these of the control group (P＜0.05); NO level, respiratory symptoms, disease impact, activity ability and SGRQ total scores reduced in both groups (P＜0.05), the decrease of the test group reduced notably (P＜0.05). Clinical control rate of the test group was 35.8%(29/81), total effective rate reached 98.8%(80/81), respectively higher than 17.3%(14/81) and 84.0%(68/81) of the control group(P＜0.05). Conclusion: Lung-tonifying blood-activating stasis-removing method could improve clinical symptoms, lung function and hypercoagulable state of the patients with COPD of lung-kidney deficiency pattern, inhibit the synthesis and release of NO, alleviate inflammatory reaction and raise quality of life.

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备注/Memo

备注/Memo:
收稿日期：2019-09-21作者简介：陈英(1978—)，女，主治医师。研究方向：内科疾病的诊治。△通讯作者：王娅(1979—)，女，主治医师。研究方向：内科疾病的诊治。
更新日期/Last Update: 2020-05-15