[1]许海燕,彭修娟,王珊,等.基于网络药理学的龙胆抗炎镇痛及治疗肝炎的作用机制研究[J].西部中医药,2020,33(08):54-60.[doi:10.12174/j.issn.1004-6852.2020.08.15]
　XU Haiyan,PENG Xiujuan,WANG Shan,et al.The Study on the Mechanism of Longdan Fighting Against Inflammation and Easing Pain and Treating Hepatitis Based on Network Pharmacology[J].Western Journal of Traditional Chinese Medicine,2020,33(08):54-60.[doi:10.12174/j.issn.1004-6852.2020.08.15]
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基于网络药理学的龙胆抗炎镇痛及治疗肝炎的作用机制研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
33
期数:
2020年08期
页码:
54-60
栏目:
出版日期:
2020-08-15

文章信息/Info

Title:
The Study on the Mechanism of Longdan Fighting Against Inflammation and Easing Pain and Treating Hepatitis Based on Network Pharmacology
文章编号:
1004-6852(2020)08-0054-07
作者:
许海燕1，彭修娟1，王珊1，侯敏娜1，刘艳红1，陈衍斌2，许刚2
1 陕西国际商贸学院，陕西 咸阳 712046； 2 陕西步长制药有限公司
Author(s):
XU Haiyan1, PENG Xiujuan1, WANG Shan1, HOU Minna1, LIU Yanhong1, CHEN Yanbin2, XU Gang2
1 Shaanxi Institute of International Trade & Commerce, Xianyang 712046, China;2 Shaanxi Buchang Pharmaceutical Inc
关键词:
网络药理学; 龙胆; 抗炎镇痛; 肝炎; 作用机制
Keywords:
network pharmacology;  Longdan;  anti inflammatory and analgesic;  hepatitis;  mechanism
分类号:
R285
DOI:
10.12174/j.issn.1004-6852.2020.08.15
文献标志码:
A
摘要:
目的：探讨龙胆抗炎镇痛及治疗肝炎的药效物质基础及作用机制。方法：借助中药整合药理学平台，结合中医药大数据，按照“理法-方药-成分-靶标-通路-活性”关联性研究，探讨其抗炎镇痛及治疗肝炎的药效物质基础及作用机制。结果：共测得龙胆活性成分16个，分别作用于1个共同靶标，11个直接靶标和30条主要通路，其药效物质基础主要为环烯醚萜、黄酮、生物碱和三萜等成分。其抗炎镇痛及治疗肝炎作用涉及的1个共同靶标为：成纤维细胞；11个直接靶标主要有：ENPP1基因、ATP合成酶亚基δ(ATP5D)、GNG2基因、PTGER1抗体、白细胞介素1β(interleukin-1β，IL-1β)、Toll样受体7(toll-like receptor-7，TLR7)、RHO蛋白等；其抗炎镇痛及治疗肝炎作用涉及内分泌系统、循环系统、神经系统、免疫系统、Toll样受体信号通路、趋化因子信号通路等。结论：龙胆的主要活性成分，可针对多靶点、多通路发挥抗炎镇痛及治疗肝炎的作用。
Abstract:
Objective: To discuss pharmacodynamic material basis and the mechanism of Longdan (Gentiana scabra Bunge.) fighting against inflammation, easing pain, and treating hepatitis. Methods: With integrated pharmacology platform of TCM, combined with TCM big data, pharmacodynamic material basis and the mechanism of Longdan (Gentiana scabra Bunge.) fighting against inflammation, easing pain, and treating hepatitis were explored according to association study of "principle and method-precription and herbs-ingredients-target-pathwayactivity". Results: Altogether 16 kinds of active ingredients were obtained, respectively working on one common target, 11 direct targets and 30 main pathways, and its pharmacodynamic material basis were Iridoids, flavone, alkaloid, triterpenoids and other ingredients mainly. One common target involved in its anti inflammatory and analgesic effects and therapeutic effects for hepatitis was fibroblasts, 11 direct targets were ENPP1 gene, ATP5D, GNG2 gene, PTGER1 antibody (inhibitory effect of PGEG1 deficiency on kidney injury in diabetic mice), IL-1β, TLR7, RHO protein and others; its therapeutic effects involved endocrine system, circulatory system, nervous system, immune system, Toll like receptor signalling pathway, chemokine signaling pathway and others. Conclusion: Main active ingredients of Longdan could develop the effects of fighting against infammation, easing pain and treating hepatitis by aiming at many targets and many pathways.

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备注/Memo

备注/Memo:
收稿日期：2019-09-27*基金项目：陕西省科技厅项目(2016SF-378)；陕西省教育厅项目(17JK0951)；陕西省科技厅项目(2018PT-07)。作者简介：许海燕(1977—)，女，硕士学位，副教授。研究方向：中药药效物质基础研究。
更新日期/Last Update: 2020-08-15