[1]龙远雄,欧阳林旗,房赤,等.基于网络药理学探讨桑贝止嗽散治疗新型冠状病毒肺炎的作用机制[J].西部中医药,2021,34(10):1-7.[doi:10.12174/j.issn.2096-9600.2021.10.01]
　LONG Yuanxiong,OUYANG Linqi,FANG Chi,et al.The Mechanism of Sangbei Cough-stopping Powder in Treating COVID-19 Based on Network Pharmacology[J].Western Journal of Traditional Chinese Medicine,2021,34(10):1-7.[doi:10.12174/j.issn.2096-9600.2021.10.01]
点击复制

基于网络药理学探讨桑贝止嗽散治疗新型冠状病毒肺炎的作用机制
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年10期
页码:
1-7
栏目:
出版日期:
2021-10-15

文章信息/Info

Title:
The Mechanism of Sangbei Cough-stopping Powder in Treating COVID-19 Based on Network Pharmacology
作者:
龙远雄, 欧阳林旗, 房赤, 彭俊, 王胜玫, 陈镇, 陈新宇, 邓桂明
湖南中医药大学第一附属医院，湖南 长沙 410007
Author(s):
LONG Yuanxiong, OUYANG Linqi, FANG Chi, PENG Jun, WANG Shengmei, CHEN Zhen, CHEN Xinyu, DENG Guiming
The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, China
关键词:
桑贝止嗽散; 新型冠状病毒肺炎; 网络药理学
Keywords:
cough-stopping powder; COVID-19; network pharmacology
分类号:
R563.1
DOI:
10.12174/j.issn.2096-9600.2021.10.01
摘要:
目的基于网络药理学探索桑贝止嗽散治疗新型冠状病毒肺炎（Corona Virus Disease 2019，COVID-19）（简称新冠肺炎）的药理机制。 方法通过中药网络药理学平台（traditional Chinese medicine systems pharmacology database and analysis platform ，TCMSP）检索桑贝止嗽散中桑白皮、浙贝母、百部、紫菀四味核心药物的主要活性成分及其对应的靶标基因，同时通过Gene Cards数据库获得新冠肺炎相关靶点，将两者进行映射，获得交集靶点作为桑贝止嗽散治疗新冠肺炎的预测靶点，利用Cytoscape软件、STRING和DAVID 6.8等数据库构建蛋白互作（protein protein interaction，PPI）网络，并进行基因本体（geneontology，GO）富集分析及基因组百科全书（kyoto encyclopedia of genes and genomes，KEGG）通路分析。 结果桑贝止嗽散4味核心药物作用于新冠肺炎的活性成分有68个，相关靶点87个，关键活性化合物8个，关键靶基因17个；GO分析显示，桑贝止嗽散治疗新冠肺炎影响的生物过程主要有脂多糖介导的信号通路，蛋白信号转导，缺氧反应等15个；KEGG通路富集显示桑贝止嗽散治疗新冠肺炎的通路主要有：PI3K-Akt信号通路，钙离子信号通路，T细胞受体信号转导，TNF信号通路等5条。 结论桑贝止嗽散可能通过以上相关通路作用于TNF、VEGFA等关键靶点，影响蛋白表达、信号通路传导等生物过程，发挥治疗新冠肺炎的作用，为实验研究提供一定的理论参考依据。
Abstract:
ObjectiveTo explore the pharmacological mechanism of Sangbei cough-stopping powder in treating COVID-19 based on network pharmacology. MethodsThe main active ingredients of Sangbaipi (Cortex Mori), Zhebeimu (Bulbus Fritillariae thunbergii ), Baibu (Japanese Stemona Root) and Ziwan (Aster tongolensis) contained in Sangbei cough-stopping powder and their corresponding target genes were searched via TCMSP, simultaneously, the related targets of COVID-19 were obtained by Gene Cards database, both were mapped to obtain the intersection target as the prediction targets of Sangbei cough-stopping powder in treating COVID-19, Cytoscape software, STRING and DAVID 6.8 were utilized to construct PPI network, and carry out GO analysis and KEGG pathway analysis. ResultsAmong four core drugs contained in Sangbei cough-stopping powder, there were 68 active ingredients acting on COVID-19, 87 related targets, eight key active compounds and 17 key target genes; GO analysis showed that the treatment of COVID-19 with Sangbei cough-stopping powder mainly involved 15 biological processes, including lipopolysaccharide mediated signal pathway, protein signal transduction and hypoxia response; KEGG pathway analysis displayed that the pathway of the treatment of COVID-19 with Sangbei cough-stopping powder contained PI3K-Akt signaling pathway, calcium signaling pathway, T cell receptor signal transduction, TNF signaling pathway and others. ConclusionSangbei cough-stopping powder develop the mechanism of treating COVID-19 possibly by acting on key targets such as TNF, VEGFA and other key targets through the above related pathways and affecting biological processes such as protein expression and signal pathway transduction, and it could provide a certain theoretical reference for experimental research.

相似文献/References:

[1]李赟,王彩弟,王建云,等.简约远程中医诊疗在新型冠状病毒肺炎隔离病区中的应用[J].西部中医药,2020,33(S1):1.
　LI Yun,WANG Caidi,WANG Jianyun,et al.The Application of Simple Remote TCM Diagnosis and Treatment to COVID-19 Quarantined Inpatient Area[J].Western Journal of Traditional Chinese Medicine,2020,33(10):1.
[2]宋忠阳,雍文兴,张利英,等.新型冠状病毒肺炎的中医临床特征与辨证论治——甘肃经验*[J].西部中医药,2020,33(S1):3.
　SONG Zhongyang,YONG Wenxing,ZHANG Liying,et al.The Experience of TCM Clinical Characteristics, Syndrome Differentiation and Treatment for COVID-19 in Gansu Province[J].Western Journal of Traditional Chinese Medicine,2020,33(10):3.
[3]杜洪霖,马战平△.西北地区新型冠状病毒肺炎的中医特点及防治*[J].西部中医药,2020,33(S1):5.
　DU Honglin,MA Zhanping.TCM Characteristics, the Prevention and Treatment of COVID-19 in Northwest China[J].Western Journal of Traditional Chinese Medicine,2020,33(10):5.
[4]潘文,李盛华,王晓萍,等.中医对新型冠状病毒肺炎的认识与防治探讨[J].西部中医药,2020,33(S1):7.
　PAN Wen,LI Shenghua,WANG Xiaoping,et al.On TCM Understanding, the Prevention and Treatment of COVID-19[J].Western Journal of Traditional Chinese Medicine,2020,33(10):7.
[5]杨海侠,张银萍△,杨长虹,等.新型冠状病毒肺炎疑似患者留观隔离期的护理体会[J].西部中医药,2020,33(S1):13.
[6]丁潇,邹忆怀△,辛大永,等.北京顺义地区新型冠状病毒肺炎的中医临床证候与CT表现[J].西部中医药,2020,33(S1):16.
　DING Xiao,ZOU Yihuai,XIN Dayong,et al.TCM Clinical Syndromes and CT Manifestations of COVID-19 in Shunyi District of Beijing[J].Western Journal of Traditional Chinese Medicine,2020,33(10):16.
[7]桑天庆,周红光△.中医药在新型冠状病毒肺炎疫情中的应用[J].西部中医药,2020,33(S1):18.
　SANG Tianqing,ZHOU Hongguang.TCM Applied to Epidemic Situation of COVID-19[J].Western Journal of Traditional Chinese Medicine,2020,33(10):18.
[8]闫向勇,李 俊,燕忠生△.武汉地区新型冠状病毒肺炎中医证候及病机特点[J].西部中医药,2020,33(S1):20.
　YAN Xiangyong,LI Jun,YAN Zhongsheng.On the Characteristics of TCM Patterns and the Pathogenesis of COVID-19 in Wuhan Region[J].Western Journal of Traditional Chinese Medicine,2020,33(10):20.
[9]曾建峰,李乐愚,缪灿铭,等.岭南道地药材在中山地区新型冠状病毒肺炎防治中的应用*[J].西部中医药,2020,33(S1):24.[doi:10.1056/NEJMoa-2001017]
　and Treatment of COVID-9 in Zhongshan Region.The Application of Lingnan Genuine Drugs to the Prevention[J].Western Journal of Traditional Chinese Medicine,2020,33(10):24.[doi:10.1056/NEJMoa-2001017]
[10]朱玉,黎玉婷,姚德蛟△.从中西医不同角度分析麻杏石甘汤治疗新型冠状病毒肺炎的作用[J].西部中医药,2020,33(S1):26.
　of Traditional Chinese Medicine and Western Medicine.The Functions of Maxing Shigan Tang in the Treatment for COVID-19 from the Angles[J].Western Journal of Traditional Chinese Medicine,2020,33(10):26.

备注/Memo

备注/Memo:
龙远雄（1990—），男，硕士学位，助理研究员。研究方向：中医临床数据分析与处理、中医药信息化与标准化。国家中医药管理局中医药部门公共卫生专项（2100409）；湖南省科技厅2020年度创新型省份建设专项抗击新冠肺炎疫情应急专题项目（2020SK3009）；湖南省高层次卫生人才“225”工程项目（湘卫函〔2019〕196号）。
更新日期/Last Update: 2021-10-15