[1]李菁浩,杨冬梨,李琳,等.中医药治疗阿霉素心脏毒性研究进展?[J].西部中医药,2021,34(11):134-140.[doi:10.12174/j.issn.2096-9600.2021.11.31]
　LI Jinghao,YANG Dongli,LI Lin,et al.Research Progress of Doxorubicin Cardiotoxicity Treated with TCM[J].Western Journal of Traditional Chinese Medicine,2021,34(11):134-140.[doi:10.12174/j.issn.2096-9600.2021.11.31]
点击复制

中医药治疗阿霉素心脏毒性研究进展?
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年11期
页码:
134-140
栏目:
研究进展
出版日期:
2021-11-15

文章信息/Info

Title:
Research Progress of Doxorubicin Cardiotoxicity Treated with TCM
作者:
李菁浩1, 杨冬梨1, 李琳2,3,4, 徐宗佩1, 李玉红2,3,4
1.天津中医药大学，天津 300193
2.天津中医药大学中医药研究院
3.天津市中药药理学重点实验室
4.方剂学教育部重点实验室
Author(s):
LI Jinghao1, YANG Dongli1, LI Lin2,3,4, XU Zongpei1, LI Yuhong2,3,4
1.Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
2.Academy of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine
3.Tianjin City Key Laboratory of Materia Medica Pharmacology
4.Key Labor
关键词:
心脏毒性; 阿霉素; 中医药; 综述
Keywords:
cardiotoxicity; doxorubicin; TCM; review
分类号:
R969.3
DOI:
10.12174/j.issn.2096-9600.2021.11.31
文献标志码:
A
摘要:
从阿霉素（doxorubicin，DOX）心脏毒性的临床表现、机制及中医药拮抗DOX心脏毒性3方面入手探讨DOX心脏毒性的中医药防治作用，指出中医药工作者以中药单体成分、中药复方、针灸为干预措施进行了相关临床研究与实验室研究，发现中医药能通过调节心肌细胞的氧化应激与钙超载、凋亡与自噬等多种途径有效降低DOX心脏毒性反应，可为临床阿霉素化疗患者减轻心脏毒性提供更多可靠方法。
Abstract:
The paper discusses the preventive and therapeutic effect of traditional Chinese medicine on DOX cardiotoxicity from three aspects: the clinical manifestation and mechanism of DOX cardiotoxicity and the antagonism of traditional Chinese medicine against DOX cardiotoxicity, it is pointed out that traditional Chinese medicine workers have carried out clinical and laboratory research with TCM monomer components, traditional Chinese medicine compound and acupuncture as intervention measures. It is found that traditional Chinese medicine can effectively reduce DOX cardiotoxicity by regulating oxidative stress, calcium overload, apoptosis and autophagy of cardiomyocytes, and it can provide more reliable methods for clinical DOX chemotherapy patients to reduce cardiotoxicity.

相似文献/References:

[1]宋元春,赛依帕△,高霞,等.黄芪总苷对阿霉素诱导损伤足细胞的保护作用[J].西部中医药,2018,31(03):19.
　SONG Yuanchun,SAI Yipa,GAO Xia,et al.Protecting Effects of Total Astragalus Glycosides on Adriamycin-induced Podocytes Injury[J].Western Journal of Traditional Chinese Medicine,2018,31(11):19.
[2]李双萍,管玲,贾景文,等.蒽环类药物心脏毒性的研究进展[J].西部中医药,2020,33(06):149.[doi:10.12174/j.issn.1004-6852.2020.06.41]
　LI Shuangping,GUAN Ling,JIA Jingwen,et al.Research Progress on Cardiotoxicity of Anthracyclines[J].Western Journal of Traditional Chinese Medicine,2020,33(11):149.[doi:10.12174/j.issn.1004-6852.2020.06.41]
[3]王竹,孙万森,刘俊田.积雪草苷对足细胞α-actinin-4 、synaptopodin蛋白及ERK/JNK通路的影响[J].西部中医药,2021,34(07):23.[doi:10.12174/j.issn.2096-9600.2021.07.06]
　WANG Zhu,SUN Wansen,LIU Juntian.Influence of Asiaticoside on Podocyte α- actinin-4, synaptopodin Protein and ERK/JNK Pathway[J].Western Journal of Traditional Chinese Medicine,2021,34(11):23.[doi:10.12174/j.issn.2096-9600.2021.07.06]

备注/Memo

备注/Memo:
李菁浩（1989—），男，硕士学位。研究方向：心脑血管疾病的中医药治疗。国家自然科学基金项目（81774017）；天津市教委科研计划项目（2017KJ140）；“十三五”期间天津市高等学校“创新团队培养计划”资助（TD13-5050）。
更新日期/Last Update: 2022-08-09