[1]刘曼曼,沈怡华,冯珍凤,等.滋月萃降糖方对2型糖尿病合并非酒精性脂肪性肝病患者血清胎球蛋白B水平及糖脂代谢的影响[J].西部中医药,2023,36(03):1-4.[doi:10.12174/j.issn.2096-9600.2023.03.01]
　LIU Manman,SHEN Yihua,FENG Zhenfeng,et al.Influence of Nourishing-pancreas Lowering-glucose Prescription on the Levels of Serum Fetuin B, Sugar-fat Metabolism in Patients with T2DM and NAFLD[J].Western Journal of Traditional Chinese Medicine,2023,36(03):1-4.[doi:10.12174/j.issn.2096-9600.2023.03.01]
点击复制

滋月萃降糖方对2型糖尿病合并非酒精性脂肪性肝病患者血清胎球蛋白B水平及糖脂代谢的影响
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年03期
页码:
1-4
栏目:
出版日期:
2023-03-14

文章信息/Info

Title:
Influence of Nourishing-pancreas Lowering-glucose Prescription on the Levels of Serum Fetuin B, Sugar-fat Metabolism in Patients with T2DM and NAFLD
作者:
刘曼曼1, 沈怡华1, 冯珍凤1, 高俊凤2, 胡春平1, 严军1
1.上海市嘉定区中医医院内分泌科，上海 201899
2.上海中医药大学，上海 201203
Author(s):
LIU Manman1, SHEN Yihua1, FENG Zhenfeng1, GAO Junfeng2, HU Chunping1, YAN Jun1
1.Endocrinology Department, Jiading District TCM Hospital, Shanghai 201899, China
2.Shanghai University of TCM, Shanghai 201203, China
关键词:
2型糖尿病; 非酒精性脂肪肝; 肽球蛋白B; 滋膵降糖方
Keywords:
T2DM; NAFLD; Fetuin-B; nourishing-pancreas lowering-glucose prescription
分类号:
R259
DOI:
10.12174/j.issn.2096-9600.2023.03.01
文献标志码:
A
摘要:
目的探讨二甲双胍片联合滋膵降糖方对初发2型糖尿病(type 2 diabetes mellitus，T2DM)合并非酒精性脂肪性肝病（nonalcoholic fatty liver disease，NAFLD）患者血清胎球蛋白B（Fetuin-B）水平及糖脂代谢的影响。 方法将T2DM合并NAFLD患者76例随机分为西药组（二甲双胍片）、联合组（二甲双胍片+滋膵降糖方），治疗12周。治疗前后采用酶联免疫吸附法测定（enzyme linked immunosorbent assay，ELISA）两组患者血清Fetuin-B水平，比较两组患者腹围（waist circumference，WC）、体质指数(body mass index，BMI)、糖化血红蛋白(glycosylated hemoglobin，HbAlc)、空腹血糖(fasting plasma glucose，FPG)、餐后2h血糖(2-hour postprandial blood glucose，2h PG)、空腹胰岛素(fasting insulin，FINS)、总胆固醇(total cholesterol，TC)、甘油三酯(triglyceride，TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol，LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol，HDL-C)及胰岛素抵抗指数(homeostasis model of insulin resistance index，HOMA-IR)、胰岛β细胞功能指数（HOMA-β）。 结果1）治疗后两组患者WC、BMI、HbA1c、FPG、2h PG、FINS、TG、LDL-C、HOMA-IR均较治疗前下降（P＜0.05）；HOMA-β较治疗前上升（P＜0.05）；血清Fetuin-B水平西药组与治疗前比较差异无统计学意义（P＞0.05），联合组较治疗前下降（P＜0.01）。2）治疗后联合组患者WC、HbA1c、FPG、2h PG、FINS、TG及HOMA-IR低于西药组（P＜0.05），HOMA-β高于西药组（P＜0.05）；血清Fetuin-B水平低于西药组（P＜0.01）。 结论滋膵降糖方协同二甲双胍片可降低T2DM合并NAFLD患者血清Fetuin-B水平及血糖血脂水平，改善患者胰岛素抵抗，调节糖脂代谢。
Abstract:
ObjectiveTo discuss the effects of nourishing-pancreas lowering-glucose prescription on the levels of serum Fetuin-B, and sugar-fat metabolism in patients with T2DM and NAFLD. MethodsAll 76 patients were randomized into Western medicine group (metformin tablets), combination group (metformin tablets+ nourishing-pancreas lowering-glucose prescription), for 12 weeks. To detect the levels of serum Fetuin-B in both groups by using ELISA method before and after the treatment, to compare WC, BMI, HbA1c, FBG, FINS, 2h PG, TC, TG, LDL-C, HDL-C, HOMA-IR and HOMA-β between both groups. Results1) After the treatment, WC, BMI, HbA1c, FPG, 2h PG, FINS, TG, LDL-C and HOMA-IR in the two groups were lowered compared with these before the treatment (P<0.05); HOMA-β was higher than that before the treatment (P<0.05); the difference had no statistical meaning when the levels of serum Fetuin-B in Western medicine group were compared with these before the treatment (P>0.05), and the combination group was reduced compared with before the treatment (P<0.01). 2)After the treatment, the improvements of WC, HbA1c, FPG, FINS, 2h PG and TG, HOMA-IR in the combination group were superior, HOMA-β was lower than that of Western medicine group (P<0.05), HOMA-β was higher than that in Western medicine group (P<0.05); the levels of Fetuin-B were lower than these of Western medicine group (P<0.01). ConclusionNourishing-pancreas lowering-glucose prescription and metformin could reduce the levels of Fetuin-B, blood glucose and blood lipid in patients with T2DM and NAFLD, improve IR and adjust glucose lipid metabolism.

相似文献/References:

[1]段尚勤.糖脂消合罗格列酮治疗2型糖尿病合并非酒精性脂肪肝疗效观察[J].西部中医药,2013,26(02):88.
　DUAN Shangqin.Clinical Observation on TangZhiXiao and Rosiglitazone Maleate in Treating Type 2 Diabetes Mellitus Complicated with Non Alcoholic Fatty Liver Disease[J].Western Journal of Traditional Chinese Medicine,2013,26(03):88.
[2]祁瑞芳.同型半胱氨酸、超敏 C- 反应蛋白在 2 型糖尿病合并脑梗死预测中的作用[J].西部中医药,2014,27(08):152.
[3]邱勇玉,李应东,赵信科,等.高血压病中医证型与 2 型糖尿病及其相关危险因素分析[J].西部中医药,2014,27(09):75.
[4]李东峰,指导：王志刚.王志刚主任医师治疗2型糖尿病“三级”防治思想辨治心得[J].西部中医药,2015,28(01):29.
[5]周雨聪,指导：刘召.红灵五黄汤治疗2型糖尿病90例[J].西部中医药,2015,28(04):99.
[6]杨国军.黄芪注射液对2型糖尿病患者血管功能及微循环状态的影响[J].西部中医药,2015,28(05):109.
[7]康学东,张瀚文.病证结合探讨2型糖尿病胰岛素抵抗[J].西部中医药,2015,28(11):112.
[8]张喜芬,赵保礼,杨立波,等.通络明目胶囊治疗糖尿病视网膜病变的随机双盲对照研究[J].西部中医药,2013,26(11):88.
　ZHANG Xifen,ZHAO Baoli,YANG Libo,et al.A Randomized, Double-blind and Placebo-controlled Study of TongLuo MingMu Capsule in Treating Diabetic Retinopathy[J].Western Journal of Traditional Chinese Medicine,2013,26(03):88.
[9]戴梅.全面干预护理对2型糖尿病患者血糖和糖化血红蛋白水平的影响[J].西部中医药,2013,26(07):109.
　DAI Mei.Intervention of Comprehensive Nursing on Blood Glucose and Glycosylated Hemoglobin of Patients with Diabetes Mellitus Type Two[J].Western Journal of Traditional Chinese Medicine,2013,26(03):109.
[10]张家林,裴瑞霞.银花痛风颗粒治疗2型糖尿病合并高尿酸血症疗效观察[J].西部中医药,2014,27(01):106.
　ZHANG Jialin,PEI Ruixia.Clinical Observation on YinHua TongFeng Granules in Treating Type 2 Diabetes Mellitus Complicated with Hyperuricemia[J].Western Journal of Traditional Chinese Medicine,2014,27(03):106.

备注/Memo

备注/Memo:
刘曼曼（1987—），女，硕士学位，主治医师。研究方向：内分泌代谢性疾病的中医药防治。上海市进一步加快中医药事业发展三年行动计划（2018—2020年）［ZY（2018-2020）-FWTX-4011］。
更新日期/Last Update: 2023-03-15