[1]司原成,任晨晨,张二伟,等.电针对营养性肥胖小鼠脂肪因子及脂肪酸合成酶的影响[J].西部中医药,2023,36(06):10-13.[doi:10.12174/j.issn.2096-9600.2023.06.03]
　SI Yuancheng,REN Chenchen,ZHANG Erwei,et al.Effects of Electroacupuncture on Adipokines and Fatty Acid Synthetase in Diet-induced Obese Mice[J].Western Journal of Traditional Chinese Medicine,2023,36(06):10-13.[doi:10.12174/j.issn.2096-9600.2023.06.03]
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电针对营养性肥胖小鼠脂肪因子及脂肪酸合成酶的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年06期
页码:
10-13
栏目:
出版日期:
2023-06-15

文章信息/Info

Title:
Effects of Electroacupuncture on Adipokines and Fatty Acid Synthetase in Diet-induced Obese Mice
作者:
司原成, 任晨晨, 张二伟, 康朝霞, 莫曦雅, 冯麟, 孙燕子, 赵超超, 李青青, 陈波
贵州中医药大学，贵州 贵阳 550025
Author(s):
SI Yuancheng, REN Chenchen, ZHANG Erwei, KANG Zhaoxia, MO Xiya, FENG Lin, SUN Yanzi, ZHAO Chaochao, LI Qingqing, CHEN Bo
Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China
关键词:
肥胖症; 电针; 脂肪因子; 脂肪酸合成酶; 小鼠; 动物实验
Keywords:
obesity; electroacupuncture; adipokines; fatty acid synthetase; mice; zoopery
分类号:
R246
DOI:
10.12174/j.issn.2096-9600.2023.06.03
文献标志码:
A
摘要:
目的探讨电针对营养性肥胖鼠脂肪因子及脂肪酸合成酶（fatty acid synthetase，FAS）的影响。 方法将50只SPF级C57BL/6小鼠，采用随机数字表法选取6只作为正常组，余下44只建立营养性肥胖小鼠模型。8周后，筛选出体质量大于正常组均值20%的肥胖鼠18只，随机均分成模型组、电针14天组、电针28天组，每组6只。观察各组小鼠的体质量、Lee’s指数、血清血脂［（cholesterol，CHO）、（triglycerides，TG）］、脂肪因子［（leptin，LP）、（adiponectin，ADPN）］及脂肪和肝脏组织中的FAS的变化情况。 结果模型组体质量、Lee’s指数、CHO、TG、LP、ADPN及脂肪和肝脏组织中的FAS含量均显著高于正常组（P＜0.01），经电针治疗后均显著下降（P＜0.01），其中电针28天组优于电针14天组（P＜0.05），且电针28天组变化明显（P＜0.05）。 结论电针可纠正营养性肥胖小鼠的血脂异常，良性调控肥胖鼠脂肪酸合成酶的代谢功能，达到减肥的效果。
Abstract:
ObjectiveTo survey the influence of electroacupuncture on adipokines and fatty acid synthetase (FAS) in diet-induced obese mice. MethodsAmong 50 SPF level C57BL/6 mice, six mice were chosen as the normal group by using random number table method, and the remaining 44 mice were built into the mice models with diet-induced obesity. After eight weeks, 18 obese rats with body weight greater than 20% of the average of the normal group were selected, randomized into the model group, 14-day electroacupuncture group and 28-day electroacupuncture group, eight mice each group. To observe body mass, Lee's index, serum lipids (CHO, TG) and adipokines (LP and ADPN) as well as the changes of FAS in fat and liver tissue of the mice in different groups. ResultsThe model group was noticeably higher than the normal group in body mass, Lee's index, CHO, TG, LP, ADPN and the contents of FAS in the fat and liver tissue (P<0.01), these indicators decreased noticeably after electroacupuncture treatment (P<0.01), among them, 28-day electroacupuncture group was better than 14-day electro- acupuncture group (P<0.05), and the changes of 28-day electroacupuncture group were remarkable (P<0.05). ConclusionElectroacupuncture could correct abnormal blood lipid and regulate the metabolic function of fatty acid synthetase positively, thus realizing the effects of losing the weight.

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备注/Memo

备注/Memo:
司原成（1988—），男，博士学位，副教授。研究方向：刺灸推拿的基础与应用研究。2022年国家中医药管理局全国名老中医药专家传承工作室建设项目；内蒙古自治区自然科学基金面上项目（2021MS08117、2022MS08022）；内蒙古自治区草原英才创新团队“中医治未病”项目（CYYCTD2018）；内蒙古自治区第八批“草原英才”个人项目（CYYC80395）；内蒙古自治区2021年“人才开发基金”项目（内人社办发［2021］171号）；内蒙古医科大学附属医院基金项目（NYFYYB2014022）；内蒙古医科大学“致远”人才计划“善学”人才项目（ZY0202021）；内蒙古医科大学2020年“治学人才”团队项目（ZY0110013）。 国家自然科学基金（81860775，82260853）；贵州省教育厅青年科技人才成长项目（黔教合KY字［2018］219）；贵州省基础研究（科学技术基金）项目（黔科合基础-ZK［2022］一般484）。
更新日期/Last Update: 2023-06-15