[1]李亮,朱晓铭,唐晓勇,等.茴香枳术汤对粘连性肠梗阻大鼠血浆内毒素的影响[J].西部中医药,2024,37(02):1-3.[doi:10.12174/j.issn.2096-9600.2024.02.01]
　LI Liang,ZHU Xiaoming,TANG Xiaoyong,et al.Effects of Huixiang Zhizhu Soup on the Levels of Plasma Endotoxin in Rats with Adhesive Intestinal Obstruction[J].Western Journal of Traditional Chinese Medicine,2024,37(02):1-3.[doi:10.12174/j.issn.2096-9600.2024.02.01]
点击复制

茴香枳术汤对粘连性肠梗阻大鼠血浆内毒素的影响
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年02期
页码:
1-3
栏目:
基础研究
出版日期:
2024-02-15

文章信息/Info

Title:
Effects of Huixiang Zhizhu Soup on the Levels of Plasma Endotoxin in Rats with Adhesive Intestinal Obstruction
作者:
李亮, 朱晓铭, 唐晓勇, 陈玉庆, 刘强光, 郑君, 乔登嫣, 骆元斌, 刘迎萍, 屈红
甘肃省中医院，甘肃 兰州 730050
Author(s):
LI Liang, ZHU Xiaoming, TANG Xiaoyong, CHEN Yuqing, LIU Qiangguang, ZHENG Jun, QIAO Dengyan, LUO Yuanbin, LIU Yingping, QU Hong
Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
关键词:
肠梗阻; 粘连性; 茴香枳术汤; 内毒素; 大鼠; 动物实验
Keywords:
intestinal obstruction;  adhesive; soup; endotoxin; rats; animal experiment
分类号:
R574.2
DOI:
10.12174/j.issn.2096-9600.2024.02.01
文献标志码:
A
摘要:
目的观察茴香枳术汤对粘连性肠梗阻大鼠血浆内毒素的影响，为深入探讨茴香枳术汤对粘连性肠梗阻微生态的作用机制提供实验依据。 方法从72只大鼠中，选择12只为正常组，其余60只制备大鼠粘连性肠梗阻模型，造模成功后随机分为假手术组，模型组，茴香枳术汤低（1.13 g/mL）、中（2.25 g、mL）、高（3.38 g/mL）剂量组，每组12只。各组给予对应药物治疗3天，末次给药后12 h股动脉取血，鲎试验偶氮基质显色法测定血浆内毒素含量；脱颈处死大鼠，取部分粘连组织行病理检查。 结果与正常组比较，模型组血浆内毒素含量显著增加（P＜0.01）；与模型组比较，假手术组及茴香枳术汤各剂量组血浆内毒素含量显著下降（P＜0.01）。病理结果显示各治疗组肠壁形态逐渐恢复，炎症消退。 结论茴香枳术汤具有良好的治疗粘连性肠梗阻的作用，其作用机制与保护肠道微生态功能有关。
Abstract:
ObjectiveTo provide experimental evidence for further exploration into the mechanism of Huixiang Zhizhu soup(HX-S) on the improvement of microecology in adhesive intestinal obstruction (AIO) by observing the effects of the decoction on serum endotoxin in AIO rats. MethodsAmong 72 rats, 12 were chosen as the normal group, and the remaining 60 were prepared into rat models with AIO, after successfully modeling, and randomized into sham operation group, the model group, low (1.13g/mL), moderate (2.25g/mL) and high (3.38g/mL) doses groups of HX-S with 12 in each group. Different groups were given the corresponding medicine for three days, blood was taken from the femoral artery 12 h after the last dose, the contents of serum endotoxin was detected in limulus amebocyte lysate test; rats were sacrificed by cervical dislocation, some adhesive tissues were taken for pathological examination. ResultsCompared with the normal group, the contents of serum endotoxin were increased obviously in the model group (P<0.01); compared with the model group, the contents of serum endotoxin were decreased remarkably in sham operation group and different doses groups of HX-S(P<0.01). Pathological results displayed that intestinal wall morphology was recovered gradually and inflammation was relieved in different treatment groups. ConclusionHX-S is effective in treating AIO, and its mechanism might be related to protecting intestinal microecology.

相似文献/References:

[1]吴志科.中西药物联合治疗术后炎性肠梗阻40例[J].西部中医药,2013,26(09):10.
　WU Zhike.Treatment for 40 Cases of Postoperative Inflammatory Ileus with Integrative Medicine[J].Western Journal of Traditional Chinese Medicine,2013,26(02):10.
[2]侯晓圆,何煜宇.术后早期炎性肠梗阻的中医治疗研究进展[J].西部中医药,2013,26(04):127.
　HOU Xiaoyuan,HE Yuyu.Progress of TCM Therapy for Early Postoperative Inflammatory Intestinal Obstruction[J].Western Journal of Traditional Chinese Medicine,2013,26(02):127.
[3]强群,盛丽,张宝洲,等.肠梗阻的分类及诊断方法[J].西部中医药,2015,28(10):139.
[4]李彦龙,任彦彦,吕巧莹,等.健胃清肠合剂对不完全性肠梗阻大鼠肠黏膜免疫屏障功能影响的实验研究[J].西部中医药,2022,35(08):19.[doi:10.12174/j.issn.2096-9600.2022.08.05]
　LI Yanlong,REN Yanyan,LYU Qiaoying,et al.Experimental Study on the Effects of Jianwei Qingchang Mixture on Intestinal Mucosal Immune Barrier Function in Rats with Incomplete Intestinal Obstruction[J].Western Journal of Traditional Chinese Medicine,2022,35(02):19.[doi:10.12174/j.issn.2096-9600.2022.08.05]
[5]盛 丽,张宝洲,强 群,等.彩超监测肠系膜上动脉流速对大鼠粘连性肠梗阻的诊断及茴香枳术汤疗效的判定*[J].西部中医药,2012,25(10):115.
　SHENG Li,ZHANG Bao-zhou,QIANG Qun,et al.Evaluation on Clinical Efficacy of HuiXiang ZhiZhuTang and Diagnosis of Adhesive Ileus in Rats through Colour Doppler Ultrasound Monitoring Superior mesenteric Artery Flow Velocity[J].Western Journal of Traditional Chinese Medicine,2012,25(02):115.
[6]杨宏武,李亮,唐晓勇△.茴香枳术汤对粘连性肠梗阻模型大鼠血浆NO、DAO的影响[J].西部中医药,2013,26(02):31.
　YANG Hongwu,LI Liang,et al.Effects of HuiXiang ZhiZhuTang on NO and DAO in the Serum of Rats with Adhesive Intestinal Obstruction[J].Western Journal of Traditional Chinese Medicine,2013,26(02):31.
[7]杨宏武,李亮,唐晓勇△.茴香枳术汤对实验性大鼠粘连性肠梗阻组织NO、DAO的影响[J].西部中医药,2013,26(03):28.
　YANG Hongwu,LI Liang,TANG Xiaoyong.Effects of HuiXiang ZhiZhuTang on NO and DAO of Experimental Rats with Adhesive Intestinal Obstruction[J].Western Journal of Traditional Chinese Medicine,2013,26(02):28.
[8]张志娟,唐锐,苗玉琴.粘连性肠梗阻的中西医结合优化护理探讨[J].西部中医药,2013,26(08):124.
　ZHANG Zhijuan,TANG Rui,MIAO Yuqin.Optimized Nursing for the Patients Suffering from Adhesive Ileus with Integrative Medicine[J].Western Journal of Traditional Chinese Medicine,2013,26(02):124.
[9]杨学峰.复方大承气汤联合抗生素治疗腹部手术后粘连性肠梗阻40例[J].西部中医药,2014,27(06):113.
　YANG Xuefeng.Compound DaChengQi Tang and Antibiotics in Treating 40 Patients with Adhesive Ileus after Abdominal Surgery[J].Western Journal of Traditional Chinese Medicine,2014,27(02):113.

备注/Memo

备注/Memo:
李亮（1979—），男，硕士学位，副主任医师。研究方向：胃肠道疾病的中西医结合治疗。甘肃省中医药管理局科研课题（GZK-2016-66），中医特色优势专科建设项目（甘卫中医函〔2022〕50号），甘肃省肠梗阻专科联盟建设项目（甘卫医政函〔2021〕132号）。
更新日期/Last Update: 2024-02-15