[1]李庆,张慧,王逍,等.醒脑解郁胶囊治疗帕金森病合并抑郁30例[J].西部中医药,2024,37(06):125-129.[doi:10.12174/j.issn.2096-9600.2024.06.29]
　LI Qing,ZHANG Hui,WANG Xiao,et al.Treatment of Parkinson′s Disease Combined with Depression with Xingnao Jieyu Capsules: 30 Cases[J].Western Journal of Traditional Chinese Medicine,2024,37(06):125-129.[doi:10.12174/j.issn.2096-9600.2024.06.29]
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醒脑解郁胶囊治疗帕金森病合并抑郁30例
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年06期
页码:
125-129
栏目:
临床研究
出版日期:
2024-06-15

文章信息/Info

Title:
Treatment of Parkinson′s Disease Combined with Depression with Xingnao Jieyu Capsules: 30 Cases
作者:
李庆, 张慧, 王逍, 冯卫星
陕西中医药大学附属医院，陕西 咸阳 712000
Author(s):
LI Qing, ZHANG Hui, WANG Xiao, FENG Weixing
Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, China
关键词:
帕金森病; 抑郁; 醒脑解郁胶囊; 盐酸普拉克索
Keywords:
Parkinson's disease; depression; capsule; pramipexole dihydrochloride
分类号:
R971+.43
DOI:
10.12174/j.issn.2096-9600.2024.06.29
文献标志码:
B
摘要:
目的观察醒脑解郁胶囊治疗帕金森病合并抑郁的临床疗效。 方法选择帕金森病合并抑郁患者86例，随机分为对照组（多巴丝肼片组，26例）、阳性药物组（多巴丝肼片联合盐酸普拉克索组，30例）及观察组（多巴丝肼片联合醒脑解郁胶囊组，30例），共治疗3个月。比较各组临床疗效、运动症状、抑郁症状评分及安全性指标。 结果各组治疗前统一帕金森病评分量表（unified Parkinson's disease rating scal
Abstract:
ObjectiveTo observe the clinical efficacy of Xingnao Jieyu capsules in the treatment of Parkinson's disease (PD) combined with depression. MethodsEighty-six patients with PD and depression were selected and randomly divided into the control group (Levodopa and Benserazide Hydrochloride tablets group, 26 cases), the positive drug group (Levodopa and Benserazide Hydrochloride tablets combined with pramipexole dihydrochloride group, 30 cases) and the observation group (Levodopa and Benserazide Hydrochloride tablets combined with Xingnao Jieyu capsule group, 30 cases), and they were treated for a total of three months. To compare clinical efficacy, motor symptoms, depression symptom scores and safety indexes between the groups. ResultsBefore the treatment, the difference had no statistical meaning in the unified Parkinson's disease rating scale (UPDRS), Hamilton depression scale (HAMD) and non-motor symptoms. question-naire (NMQuest) scores (P>0.05). After six and twelve weeks of medication, the UPDRS scores of the positive drug group and the observation group decreased, but the difference was not statistically significant between the groups (P>0.05); the HAMD and NMQuest scores of the positive drug group and the observation group decreased significantly, and the difference was statistically significant when compared with the control group (P<0.05), and the difference between the positive drug group and the observation group had no statistical meaning (P>0.05). The total effective rates of improving depression and non-motor symptoms in both the positive drug group and the observation group were significantly higher than that in the control group (P<0.05). No obvious abnormalities were seen in the relevant laboratory tests before and after treatment in each group (P>0.05). ConclusionThe combination of Levodopa and Benserazide Hydrochloride tablets and Xingnao Jieyu capsules, the application of Levodopa and Benserazide Hydrochloride tablets and pramipexole dihydrochloride can improve the symptoms of depression in PD patients with good efficacy and safety, among which, Xingnao Jieyu capsules are inexpensive and effective.

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备注/Memo

备注/Memo:
李庆（1988—），男，硕士学位，主治医师。研究方向：脑病的中西医结合治疗。陕西省科技厅项目（2018SF-297）；陕西省创新能力支撑计划（2017KCT-26）；陕西中医药大学附属医院课题（2020LCJD006）。
更新日期/Last Update: 2024-06-15