[1]蒋志雄,朱智德,卢健棋,等.从痰瘀理论探讨自噬在高血压中的作用机制[J].西部中医药,2025,38(07):103-108.[doi:10.12174/j.issn.2096-9600.2025.07.20]
　JIANG Zhixiong,ZHU Zhide,LU Jianqi,et al.The Influence of Autophagy in Hypertension Based on Phlegm-stasis Theory[J].Western Journal of Traditional Chinese Medicine,2025,38(07):103-108.[doi:10.12174/j.issn.2096-9600.2025.07.20]
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从痰瘀理论探讨自噬在高血压中的作用机制()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年07期
页码:
103-108
栏目:
研究进展
出版日期:
2025-07-15

文章信息/Info

Title:
The Influence of Autophagy in Hypertension Based on Phlegm-stasis Theory
作者:
蒋志雄1, 朱智德2, 卢健棋3,4, 祁祥5, 何晓羚6
1.广西国际壮医医院，广西 南宁 530001
2.广西中医药大学，广西 南宁 530200
3.广西中医药大学第一附属医院，广西 南宁 530023
4.国家中医心血管病临床医学研究中心广西分中心，广西 南宁 530023
5.河南中医药大学中医学院（仲景学院），河南 郑州 450046
6.深圳市盐田区妇幼保健院，广东 深圳 518081
Author(s):
JIANG Zhixiong1, ZHU Zhide2, LU Jianqi3,4, QI Xiang5, HE Xiaoling6
1.Guangxi International Zhuang Medicine Hospital, Nanning 530001, China
2.Guangxi University of Chinese Medicine, Nanning 530200, China
3.The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China
4.Guangxi Branch, National Center for Cardiovascular Diseases, Nanning 530023, China
5.Henan University of Chinese Medicine, College of Traditional Chinese Medicine (Zhongjing College), Zhengzhou 450046, China
6.Yantian District Maternal and Child Health Care Hospital of Shenzhen, Shenzhe 518081, China
关键词:
高血压; 痰瘀; 自噬; 作用机制; 研究进展
Keywords:
hypertension; phlegm-stasis; autophagy; the mechanism; research progress
分类号:
R255.3
DOI:
10.12174/j.issn.2096-9600.2025.07.20
文献标志码:
A
摘要:
从中医“痰瘀理论”角度出发，分析自噬发生发展过程与高血压的关联性及作用机制。自噬平衡有助于维持细胞功能；自噬不足导致细胞受损，细胞器及代谢废物无法及时清除，致使“痰瘀”堆积；自噬过度则导致细胞结构破坏，释放细胞毒性颗粒及炎症物质，致使“痰瘀”生成。高血压中存在自噬异常的情况，导致出现内皮细胞损伤、炎症因子和相关代谢产物产生，因此自噬的病理机制与“痰瘀”在高血压病中的发病机制存在内在联系，为高血压的研究及防治提供新思路。
Abstract:
The article analyses the relationship between the occurrence and development of autophagy, and hypertension, and the mechanism from the angle of "phlegm-stasis" theory in TCM, presenting that autophagy balance could help maintain cellular function, inadequate autophagy could lead to cell damage so that organelles and metabolic wastes cannot be removed in time, resulting in the accumulation of "phlegm-stasis", while excessive autophagy would damage cell structure, the release of cytotoxic particles and inflammatory substances could lead to the formation of "phlegm-stasis". Meanwhile, abnormal autophagy in hypertension could cause endothelial cell damage, the production of inflammatory factors and the relevant metabolites, the internal connections between pathological mechanism of autophagy, and the pathogenesis of "phlegm-stasis" in hypertension were revealed, in order to discuss the influence of autophagy on hypertension from phlegm-stasis theory, which could provide new thinking for the study and prevention and treatment of hypertension.

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备注/Memo

备注/Memo:
蒋志雄（1995—），男，硕士学位，医师。研究方向：心血管疾病的中医药防治。广西自然科学基金（2017GXNSFAA198302）。
更新日期/Last Update: 2025-07-15