[1]郭燕,逯克娜,林寒梅.补肾活血类中药对黄体功能不全大鼠模型干预研究的系统评价[J].西部中医药,2025,38(09):75-79.[doi:10.12174/j.issn.2096-9600.2025.09.14]
　GUO Yan,LU Ke?na,LIN Hanmei.Systematic Evaluation of the Intervention of Kidney-tonifying Blood-activating Herbs in Rat Models with Luteal Phase Deficiency[J].Western Journal of Traditional Chinese Medicine,2025,38(09):75-79.[doi:10.12174/j.issn.2096-9600.2025.09.14]
点击复制

补肾活血类中药对黄体功能不全大鼠模型干预研究的系统评价()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年09期
页码:
75-79
栏目:
二次研究
出版日期:
2025-09-15

文章信息/Info

Title:
Systematic Evaluation of the Intervention of Kidney-tonifying Blood-activating Herbs in Rat Models with Luteal Phase Deficiency
作者:
郭燕, 逯克娜, 林寒梅
广西中医药大学，广西 南宁 530023
Author(s):
GUO Yan, LU Ke?na, LIN Hanmei
Guangxi University of Chinese Medicine, Nanning 530023, China
关键词:
黄体功能不全; 生殖激素; 补肾活血; 动物模型; 系统评价
Keywords:
luteal phase deficiency; reproductive hormone; kidney-tonifying blood-activating; animal models; systematic evaluation
分类号:
R285.5
DOI:
10.12174/j.issn.2096-9600.2025.09.14
文献标志码:
A
摘要:
目的系统评价补肾活血类中药对黄体功能不全（luteal phase deficiency，LPD）大鼠模型生殖轴激素水平的干预作用。 方法检索PubMed，Embase，Cochrane Library、Web of science、Ovid、中国知网、重庆维普中文科技期刊数据库、万方数据知识服务平台、中国生物医学文献数据库，筛选补肾活血类中药干预LPD大鼠模型的实验研究，提取LPD大鼠模型资料，基于SYRCLE动物实验偏倚风险评估工具（其内容与Cochrane偏倚风险评估工具切合）实施评估，运用RevMan 5.4软件进行Meta分析。 结果共纳入9个研究，研究对象为BN/SD大鼠，均为随机对照实验。Meta分析结果显示，与模型组比较，补肾活血类中药可提高孕酮（progesterone，P）（SMD=1.56，95%CI：0.58～2.54，P=0.002）水平，降低催乳素（prolactin，PRL）（SMD=-1.32，95%CI：-1.93～-0.70，P＜0.000 1）含量，卵泡刺激素（follicle stimulating hormone，FSH）（SMD=1.35，95%CI：-3.15～5.85，P=0.56）、黄体生成素（luteinizing hormone，LH）（SMD=0.92，95%CI：-2.70～4.54，P=0.62）及雌二醇（estradiol，E2）（SMD=0.65，95%CI：-1.10～2.40，P=0.47）差异均无统计学意义。 结论补肾活血类中药可以改善LPD大鼠的生殖与卵巢功能，改变内分泌生殖激素水平，对生殖功能起到一定保护作用。因纳入文献数量与质量的局限性，此结论仍待进一步纳入高质量研究给予验证。
Abstract:
ObjectiveTo systematically assess the intervention effects of kidney-tonifying blood-activating herbs on the levels of hormone in rat models with luteal phase deficiency (LPD). MethodsExperimental studies of kidney-tonifying blood-activating herbs in the intervention of LPD rat models were screened by searching from PubMed, Embase, Cochrane Library, Web of science, Ovid, CNKI, VIP, Wanfang data and SinoMed, for the extraction of the data of LPD rat models, the evaluation was carried out based on SYCRLE’s risk of bias tool for animal studies (Its content is consistent with the Cochrane bias risk), and Meta analysis was performed using RevMan 5.4. ResultsAltogether nine studies were included, and the subjects were BN/SD rats, belonging to randomized controlled experiments. Meta analysis results displayed that, compared with the model group, kidney-tonifying blood-activating herbs could evaluate the levels of P (SMD=1.56, 95%CI: 0.58-2.54, P=0.000 2) and decrease the contents of PRL (SMD=-1.32, 95%CI: -1.93--0.70, P<0.0001), the difference had no statistical meaning in the comparisons of FSH (SMD=1.35, 95%CI: -3.15-5.85, P=0.56), LH (SMD=0.92, 95%CI: -2.70-4.54, P=0.62) and E2 (SMD=0.65, 95%CI:-1.10-2.40, P=0.47). ConclusionKidney-tonifying blood-activating herbs could improve reproductive and ovarian function, change the levels of endocrine and reproductive hormones, and protect reproductive function. The conclusion still needs to be further validated by high quality studies owing to the limitations of the quantity and quality of the included literature.

相似文献/References:

[1]吴国琳,李天一△,余国友,等.复方玄驹胶囊对不育症大鼠精子质量及生殖激素的影响*[J].西部中医药,2013,26(02):12.
　WU Guolin,LI Tianyi,Y U Guoyou,et al.Clinical Effects of FuFang XuanJu Capsule on Quality of Sperm and Reproductive Hormone in Rats with Infertility[J].Western Journal of Traditional Chinese Medicine,2013,26(09):12.
[2]王雪芳,路艳清.滋阴补肾方治疗肝肾阴虚围绝经期功血40例[J].西部中医药,2014,27(12):81.

备注/Memo

备注/Memo:
郭燕（1987—），女，在读硕士研究生，主治医师。研究方向：中医药防治女性不孕不育。国家自然科学基金地区基金（82160919）；广西自然科学基金（2023GXNSFBA026219）；广西中医药适宜技术开发与推广项目（GZSY20-24）；林寒梅广西名中医工作室建设项目（2022004-005-01）；广西中医药大学2021年校级研究生科研创新项目（YCBXJ2021016）。
更新日期/Last Update: 2025-09-15