[1]盛松,徐凤芹.穴位贴敷治疗腹泻的多中心回顾性队列研究——基于广义估计方程的事后分析[J].西部中医药,2026,39(02):96-100.[doi:10.12174/j.issn.2096-9600.2026.02.19]
　SHENG Song,XU Fengqin.A Multicenter Retrospective Cohort Study on Acupoint Application Therapy for Diarrhea: Based on Post-Hoc Analysis of Generalized Estimating Equations[J].Western Journal of Traditional Chinese Medicine,2026,39(02):96-100.[doi:10.12174/j.issn.2096-9600.2026.02.19]
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穴位贴敷治疗腹泻的多中心回顾性队列研究——基于广义估计方程的事后分析()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
39
期数:
2026年02期
页码:
96-100
栏目:
二次研究
出版日期:
2026-02-15

文章信息/Info

Title:
A Multicenter Retrospective Cohort Study on Acupoint Application Therapy for Diarrhea: Based on Post-Hoc Analysis of Generalized Estimating Equations
作者:
盛松, 徐凤芹
中国中医科学院西苑医院，北京 100091
Author(s):
SHENG Song, XU Fengqin
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
关键词:
腹泻; 穴位贴敷; 真实世界研究; 广义估计方程
Keywords:
diarrhea; acupoint application; real-world study; generalized estimating equations
分类号:
R259
DOI:
10.12174/j.issn.2096-9600.2026.02.19
文献标志码:
A
摘要:
目的基于广义估计方程（generalized estimating equations，GEE）对穴位贴敷治疗腹泻的回顾性队列研究的重复测量数据进行事后二次分析。 方法连续回顾性收集全国2548家社区医院在春播万象云诊所平台注册登记的腹泻患者。采用GEE分析穴位贴敷对多个时段腹泻痊愈的综合干预作用，依从STROBE声明展示多套调整策略下的结果。敏感性分析包括基于倾向评分匹配法（propensity score matching，PSM）的单因素分析、倾向性评分调整回归（covariate adjustment using propensity score，CAPS）、逆概率加权（inverse probability of treatment weighting，IPTW）、标准化死亡比加权（standard mortality ratio weighting，SMRW）和E值。 结果调整Ⅱ模型显示贴敷组疗效优于非贴敷组（OR=1.28，95%CI：1.02～1.60，P=0.031）；基于PSM的单因素回归、CAPS以及IPTW和SMRW效应量与多元回归结果方向一致，敏感性分析结果提示穴位贴敷治疗腹泻有效；调整Ⅱ模型效应量对应的E值为1.52。 结论国内人群中，穴位贴敷治疗腹泻有效，但是目前证据等级有限，未来仍需进一步开展高质量的前瞻性研究。
Abstract:
ObjectiveTo conduct a post-hoc secondary analysis, based on generalized estimating equations (GEE), on repeated-measures data from a retrospective cohort study of acupoint application therapy for diarrhea. MethodsPatients with diarrhea were continuously and retrospectively enrolled from 2,548 community hospitals nationwide that had registered on the Chunbo Wanxiang Cloud Clinic platform. GEE was adopted to analyze the comprehensive intervention effects of acupoint application therapy on diarrhea remission across multiple time points, results under multiple adjustment strategies are presented in accordance with the STROBE Statement. Sensitivity analysis covered single-factor analysis based on PSM, CAPS, IPTW, SMRW and E value. ResultsAdjusted model II displayed that clinical effects of acupoint application group were better than these of non acupoint application group (OR=1.28, 95%CI:1.02～1.60, P=0.031); the direction of single-factor analysis based on PSM, CAPS, IPTW, SMRW effect size was consistent with that of the multivariate regression results, sensitivity analysis results suggested that acupoint application was effective in treating diarrhea; the E-value for the effect estimate in adjusted model II was 1.52. ConclusionAcupoint application therapy is effective against diarrhea in China. However, the existing evidence is of low quality, future research efforts should focus on conducting high-quality prospective trials.

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备注/Memo

备注/Memo:
国家中医药管理局中医药循证能力建设项目（ZZ13-024-4）。盛松（1987—），男，博士学位，副主任医师。研究方向：中西医结合防治急危重症。
更新日期/Last Update: 2026-02-15