[1]孙瑜,耿莹,查海峰,等.菖蒲郁金汤加味对痰瘀热结型急性重型颅脑损伤昏迷患者的促醒效果观察[J].西部中医药,2026,39(05):161-164.[doi:10.12174/j.issn.2096-9600.2026.05.31]
　SUN Yu,GENG Ying,ZHA Haifeng,et al.Observation on the Consciousness-promoting Effect of Modified Changpu Yujin Decoction in Patients with Coma Induced by Acute STBI of Phlegm-Stasis-Heat Binding Type[J].Western Journal of Traditional Chinese Medicine,2026,39(05):161-164.[doi:10.12174/j.issn.2096-9600.2026.05.31]
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菖蒲郁金汤加味对痰瘀热结型急性重型颅脑损伤昏迷患者的促醒效果观察()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
39
期数:
2026年05期
页码:
161-164
栏目:
临床研究
出版日期:
2026-05-15

文章信息/Info

Title:
Observation on the Consciousness-promoting Effect of Modified Changpu Yujin Decoction in Patients with Coma Induced by Acute STBI of Phlegm-Stasis-Heat Binding Type
作者:
孙瑜, 耿莹, 查海峰, 胡希希, 查丽
江阴市中医院，江苏 江阴 214400
Author(s):
SUN Yu, GENG Ying, ZHA Haifeng, HU Xixi, ZHA Li
Jiangyin TCM Hospital, Jiangyin 214400, China
关键词:
颅脑损伤; 菖蒲郁金汤; 痰瘀热结证; 促醒; 超氧化物歧化酶; 一氧化氮
Keywords:
traumatic brain injury; decoction; phlegm-stasis-heat binding type; consciousness-promoting effect; SOD; NO
分类号:
R269
DOI:
10.12174/j.issn.2096-9600.2026.05.31
文献标志码:
B
摘要:
目的探讨菖蒲郁金汤加味对痰瘀热结型重型颅脑损伤（severe traumatic brain injury，STBI）昏迷患者的促醒效果。 方法纳入100例STBI伴昏迷患者，采用随机数字表法分为观察组和对照组各50例。两组均予常规干预措施，对照组在常规干预基础上予盐酸金刚烷胺片治疗，观察组在对照组基础上予菖蒲郁金汤加味治疗。治疗4周后比较两组患者临床疗效、格拉斯哥昏迷量表（glasgow coma scale，GCS）评分、颅内压值及血清超氧化物歧化酶（superoxide dismutase，SOD）和一氧化氮（nitric oxide，NO）水平。 结果观察组总有效率［84.00%（42/50）］高于对照组［66.00%（33/50）］（P＜0.05）。治疗2周及4周后，两组患者GCS评分均升高，观察组升高更明显（P＜0.05）；两组患者颅内压均降低，观察组降低更明显（P＜0.05）。治疗4周后两组患者血清SOD水平均升高，NO水平均降低，观察组改善更明显（P＜0.05）。 结论菖蒲郁金汤加味对痰瘀热结型STBI昏迷患者的促醒效果明显，可有效降低颅内压，调节血清SOD与NO水平。
Abstract:
ObjectiveTo investigate the consciousness-promoting effect of modified Changpu Yujin decoction in treating comatose patients suffering from severe traumatic brain injury (STBI) characterized by the intertwined pattern of phlegm, blood stasis, and heat. MethodsA total of 100 STBI patients with coma were enrolled and randomly divided into an observation group and a control group using a random number table method, with 50 patients in each group. Both groups received routine interventions. The control group was additionally treated with amantadine hydrochloride tablets, while the observation group received modified Changpu Yujin decoction on the basis of the control group’s treatment. After four weeks of treatment, the two groups were compared in terms of clinical efficacy, Glasgow Coma Scale (GCS) score, intracranial pressure (ICP) value, and serum levels of superoxide dismutase (SOD) and nitric oxide (NO). ResultsTotal effective rate of the observation group was [84.00%(42/50)], higher than [66.00%(33/50)] of the control group (P<0.05). Both groups showed an increase in GCS scores after two and four weeks of the treatment, while the increase of the observation group was more noticeable (P<0.05); ICP decreased in both groups, with a more significant decrease in the observation group (P<0.05). After four weeks of treatment, serum SOD levels were increased and NO levels were decreased in both groups, with more significant improvements in the observation group (P<0.05). ConclusionModified Changpu Yujin decoction significantly promotes awakening in comatose STBI patients with phlegm-stasis-heat binding type, effectively reduces ICP, and regulates serum SOD and NO levels.

相似文献/References:

[1]张广厚.康复疗法治疗轻中度颅脑损伤患者50例[J].西部中医药,2012,25(09):39.
　ZHANG Guang-hou.Effects of Rehabilitation Therapy in Treating 50 Patients with Low to Moderate Craniocerebral Injury[J].Western Journal of Traditional Chinese Medicine,2012,25(05):39.
[2]李莉.肢体功能训练对颅脑损伤患者肢体功能、神经功能和日常生活能力的影响[J].西部中医药,2014,27(12):124.
[3]杨梅.重型颅脑损伤100例院前急救分析[J].西部中医药,2013,26(09):74.
　YANG Mei.Analysis on Pre-hospital Care for 100 Patients with Severe Craniocerebral Injury[J].Western Journal of Traditional Chinese Medicine,2013,26(05):74.
[4]范小璇,赵晓平,张毅,等.颅脑损伤相关疾病中医病名的规范性[J].西部中医药,2016,29(07):54.
　FAN Xiaoxuan,ZHAO Xiaoping,ZHANG Yi,et al.The Uniformity of TCM Disease Name of Craniocerebral Injury Related Disease[J].Western Journal of Traditional Chinese Medicine,2016,29(05):54.
[5]高汉媛,史正刚△,尚菁,等.菖蒲郁金汤对TS模型大鼠行为及纹状体单胺类神经递质的影响[J].西部中医药,2017,30(11):28.
　GAO Hanyuan,SHI Zhenggang,et al.The Effects of ChangPu YuJin Decoction on the Behavior and Monoamine Neurotransmitter in Corpus Striatum of TS Rat Model[J].Western Journal of Traditional Chinese Medicine,2017,30(05):28.

备注/Memo

备注/Memo:
江苏省自然科学基金（BK20171061）。孙瑜（1986—），女，主管护师。研究方向：护理管理。
更新日期/Last Update: 2026-05-15