[1]王春爱,王迎斌,贾国龙,等.豆腐果苷对大鼠坐骨神经压迫性模型机械痛敏和热痛敏的影响[J].西部中医药,2012,25(07):20-22.
 WANG Chun-ai,WANG Ying-Bin,JIA Guo-long,et al.The Effect of Helicid on MWT and TWL in Rat Model with Chronic Compression Injury of Sciatic Nerve[J].Western Journal of Traditional Chinese Medicine,2012,25(07):20-22.
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豆腐果苷对大鼠坐骨神经压迫性模型机械痛敏和热痛敏的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
25
期数:
2012年07期
页码:
20-22
栏目:
方药·药理研究
出版日期:
2012-07-15

文章信息/Info

Title:
The Effect of Helicid on MWT and TWL in Rat Model with Chronic Compression Injury of Sciatic Nerve
文章编号:
1004-6852(2012)07-0020-03
作者:
王春爱1王迎斌2贾国龙1谢建琴2
1 甘肃省中医院,甘肃 兰州 730050; 2 兰州大学第二医院
Author(s):
WANG Chun-ai1 WANG Ying-Bin2 JIA Guo-long1 XIE Jian-Qin2
1 Gansu Province Hospital of Traditional Chinese Medicine, Lanzhou 730050, China; 2 Second Hospital of Lanzhou University
关键词:
豆腐果苷神经病理性疼痛机械缩足反射阈值热缩足潜伏期大鼠实验动物
Keywords:
helicid neuropathic pain mechanical withdrawal threshold(MWT) thermal withdrawal latency (TWL) rat experimental animal
分类号:
R285.5
文献标志码:
A
摘要:
目的:观察豆腐果苷(helicid)对坐骨神经慢性压迫性模型(CCI)大鼠机械性缩足反射阈值(MWT)和热缩足潜伏期(TWL)的影响;探讨豆腐果苷在神经病理疼痛中的调节作用。方法:将32只180~220 g Wistar雄性大鼠随机分为4组(n=8);分别为Sham组(假手术组)、CCI组(CCI模型组)、豆腐果苷低剂量组(H1)和豆腐果苷高剂量组(H2)。4组分别于CCI手术前1天、CCI手术后第10天灌胃给药,1次/d,连续10天测定后肢MWT和TWL。结果:CCI手术后第9天Sham组、CCI组、H1组、H2组MWT和TWL值分别与术前基础值比较,Sham组无差异(P>0.05),CCI组、H1组、H2组均有差异(P<0.05),CCI模型制作成功。给药后第1~10天,H1组、H2组MWT和TWL值分别与CCI组组间比较,MWT和TWL明显升高(P<0.05),H2组较H1组保持较高水平。结论:口服豆腐果苷能剂量依赖性提高CCI大鼠机械性缩足反射阈值,延长热缩足潜伏期;可延缓大鼠神经病理性疼痛的形成。
Abstract:
Objective: To observe the effect of helicid on mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) in rat model with chronic compression injury of sciatic nerve as well as to explore its regulation during the development of neuropathic pain. Method: Thirty-two rats were randomly divided into four groups (n=8): sham group (sham operation), CCI group (group of CCI models), low dose group of helicid (H1) and high dose group of helicid(H2). Four groups were administered with drugs intragastrically at the day before operation and the tenth day after operation, once each day. MWT and TWL of hind legs were tested for ten consecutive days. Result: At the ninth day after CCI surgery sham group,CCI group, H1group and H2 group were compared with basic indexes of MWT and TWL before operation, sham group showed no difference(P>0.05), CCI group, H1group and H2 group demonstrated differences (P<0.05), models with CCI were established successfully at the ninth day after CCI operation. During the first day to tenth day after medication, H1 group and H2 group were compared with CCI group respectively, indicating that MWT and TWL increased significantly (P<0.05) as well as H2 group was higher than H1 group. Conclusion: Oral helicid can raise MWT of CCI rat dose-dependently, delay TWL and postpone the development of neuropathic pain of rat.

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[1]王春爱,谢建琴,王迎斌,等.豆腐果苷对疼痛大鼠脊髓背角c—fos表达的影响[J].西部中医药,2012,25(12):10.
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备注/Memo

备注/Memo:
收稿日期:2012-02-27 作者简介:王春爱(1971—),女,硕士学位,副主任医师。研究方向:疼痛、重症医学。
更新日期/Last Update: 2012-07-15