[1]张 伟,李 晶△,宋 敏,等.淫羊藿总黄酮对去势大鼠钙、磷代谢的影响[J].西部中医药,2012,25(08):30-32.
　ZHANG Wei,LI Jing,SONG Min,et al.Influence of Total Flavonoids from YinYangHuo on Calcium and Phosphorus Metabolism of Emasculate Rat[J].Western Journal of Traditional Chinese Medicine,2012,25(08):30-32.
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淫羊藿总黄酮对去势大鼠钙、磷代谢的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
25
期数:
2012年08期
页码:
30-32
栏目:
出版日期:
2012-08-15

文章信息/Info

Title:
Influence of Total Flavonoids from YinYangHuo on Calcium and Phosphorus Metabolism of Emasculate Rat
文章编号:
1004-6852(2012)08-0030-03
作者:
张 伟1，李 晶2△，宋 敏3，谢兴文2，张彦军4
1 会宁县中医医院，甘肃 会宁 730700； 2 甘肃省中医药研究院；3 甘肃中医学院； 4 甘肃省中医院
Author(s):
ZHANG Wei1, LI Jing2△, SONG Min3, XIE Xing-wen2, ZHANG Yan-jun4
1 Huining County Hospital of TCM, Huining 730700, China; 2 Gansu Province Academy of Chinese Medicine; 3 Gansu University of Traditional Chinese Medicine; 4 Gansu Province Hospital of Traditional Chinese Medicine
关键词:
淫羊藿总黄酮; 钙、磷代谢; 去势大鼠
Keywords:
total flavonoids of YinYangHuo(Epimedium davidii Franch);  metabolism of calcium and phosphorus;  emasculate rat
分类号:
R285.5
文献标志码:
A
摘要:
目的：探讨淫羊藿总黄酮对去势大鼠钙、磷代谢的影响。方法：将60只10月龄SPF级雌性SD大鼠按照体质量以随机数字表法分为正常对照组、模型对照组、淫羊藿总黄酮低、中、高剂量组和β-雌二醇组6组，除正常对照组外，其余各组均行双侧卵巢切除术，术后一周给予淫羊藿总黄酮高、中、低剂量和雌二醇进行干预，观察各组雌二醇水平与子宫系数、全身及不同骨密度、血清生化指标的变化情况。结果：模型对照组较其余各组尿钙/肌酐、尿磷/肌酐显著上升（P＜0.01），各组间血钙、磷差异无统计学意义。结论：大鼠去势后尿钙/肌酐、尿磷/肌酐显著上升，淫羊藿总黄酮可抑制去势大鼠钙、磷的丢失。
Abstract:
Objective: To explore the influence of total flavonoids from YinYangHuo(Epimedium davidii Franch) on calcium and phosphorus metabolism of emasculate rat. Method: Sixty rats were divided into six groups with the method of random number table: normal control group, model control group, low, middle and high dose groups of total flavonoids from YinYangHuo and β-estradiol group. Except normal control group, the rats in other groups were administered with bilateral oophorectomy and intervened with low, middle and high dose of total flavonoids from YinYangHuoo and estradiol. Changes of serum biochemistry indexes, bone density of whole body and parts, uterine ratio and estradiol levels were observed. Result: Urinary calcium/creatinine, urinary phosphorus/creatinine in model control group increased significantly than other groups (P＜0.01), comparisons of other groups showed no statistical meaning in blood calcium and phosphorus. Conclusion: Urinary calcium/creatinine, urinary phosphorus/creatinine of emasculate rats could rise remarkably and total flavonoids from YinYangHuo can inhibit the loss of calcium and phosphorus in emasculate rat.

相似文献/References:

[1]李晶,宋敏△,罗晓,等.淫羊藿总黄酮对去势大鼠股骨骨组织形态学及生物力学的影响*[J].西部中医药,2014,27(07):13.
　LI Jing,SONG Min,LUO Xiao,et al.Effects of Total Flavonoids of Epimedium on Biodynamics and Bone Morphological Metrology of Ovariectomized Rats[J].Western Journal of Traditional Chinese Medicine,2014,27(08):13.
[2]李晶,谢兴文,宋敏.淫羊藿总黄酮对去势大鼠腰椎椎体生物力学的影响[J].西部中医药,2016,29(01):15.
　LI Jing,XIE Xingwen,SONG Min.Influence of Total Flavonoids from YinYangHuo on Lumbar Vertebral Body Biomechanics of Castrated Rats[J].Western Journal of Traditional Chinese Medicine,2016,29(08):15.

备注/Memo

备注/Memo:
收稿日期：2012-04-10 *基金项目：甘肃省自然科学基金计划项目(编号3ZS061-A25-109) 作者简介：张伟(1973—)，男，主治医师。研究方向：中医骨伤常见病的诊治。 △通讯作者：李晶(1983—)，男，硕士学位。研究方向：骨关节疾病的中医药防治。
更新日期/Last Update: 2012-08-15