[1]彭晓明,陈林庆△,张震文,等.温肾胶囊联合盐酸曲唑酮治疗抑郁症伴勃起功能障碍的临床研究*[J].西部中医药,2012,25(12):4-7.
　PENG Xiao-ming,CHEN Lin-qing,ZHANG Zhen-wen,et al.Clinical Study on WenShen Capsule and Trazodone Hydrochloride in the Treatment for Depression Complicated with Erectile Dysfunction[J].Western Journal of Traditional Chinese Medicine,2012,25(12):4-7.
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温肾胶囊联合盐酸曲唑酮治疗抑郁症伴勃起功能障碍的临床研究*
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
25
期数:
2012年12期
页码:
4-7
栏目:
出版日期:
2012-12-15

文章信息/Info

Title:
Clinical Study on WenShen Capsule and Trazodone Hydrochloride in the Treatment for Depression Complicated with Erectile Dysfunction
文章编号:
1004-6852(2012)11-0004-04
作者:
彭晓明，陈林庆△，张震文，郭霞
甘肃中医学院附属医院脑病科，甘肃 兰州 730020
Author(s):
PENG Xiao-ming, CHEN Lin-qing△ , ZHANG Zhen-wen, GUO Xia
Encephalopathy Department in University Hospital of Gansu Traditional Chinese Medicine, Lanzhou 730020, China
关键词:
抑郁症; 勃起功能障碍; 温肾胶囊; 临床研究
Keywords:
depression;  erectile dysfunction (ED);  WenShen capsule;  clinical study
分类号:
R749.42
文献标志码:
A
摘要:
目的：通过观察温肾胶囊联合盐酸曲唑酮治疗抑郁症伴勃起功能障碍的临床疗效，揭示中医药在该领域的理论、治疗优势，为该病的临床治疗和温肾胶囊的临床推广提供一定的理论依据。方法：将60例符合诊断的抑郁症伴勃起功能障碍患者采用随机数字表法分为治疗组和对照组各30例，对照组给予盐酸曲唑酮口服，50-150mg/次，1次/d；治疗组在对照组基础上给予温肾胶囊6粒/次，早晚口服，连续观察8周,在治疗开始后第0、1、2、4、8周记录病情变化。结果：①治疗后治疗组和对照组汉密顿抑郁量表(HAMD)得分均明显下降，组间比较有统计学意义(P＜0.05)；②治疗后治疗组勃起ED临床疗效总有效率为93.3%；对照组为76.3%，治疗组疗效明显优于对照组(P＜0.05)；③治疗组治疗后，勃起功能评分积分较治疗前明显增加，差异有显著性(P＜0.05)，与对照组比较，差异有显著性(P＜0.05)；④治疗后治疗组与对照组患者血清中T浓度均升高，E2、LH、PRL浓度降低；而治疗组较对照组血清性激素中睾酮T，雌二醇E2、催乳素PRL浓度改变尤其明显，差异有显著性(P＜0.05)，对于LH两组浓度均明显下降，但组间比较无显著差异(P＞0.05)。结论：温肾胶囊合并盐酸曲唑酮治疗抑郁症伴勃起功能障碍的临床疗效优于单用盐酸曲唑酮组。
Abstract:
Objective: To provide theoretical evidence for therapy of depression complicated with erectile dysfunction(ED) and clinical spread of WenShen capsule through observation to reveal the theory and advantages of TCM. Method: Sixty patients were divided into two groups with random number table. Control group took trazodone hydrochloride orally, 50-150mg each time, once per day; treatment group were also given with WenShen capsule,six pills each time, twice each day. Both groups were observed for eight consecutive weeks and disease changes were recorded at the beginning, the first, second, fourth and eighth week. Result: ① After treating, scale of HAMD in treatment group and control group decreased significantly and the difference between both groups showed obvious statistical meaning (P＜0.05). ② After treating, total effective rate of treatment group was 93.3%,total effective rate of control group was 76.3%, clinical effects of treatment group were superior to that of control group remarkably (P＜0.05). ③ After treating, ED scales of treatment group were higher than before treating with remarkable difference (P＜0.05), compared with control group, the difference was remarkable (P＜ 0.05). ④ Concentration of T in serum rose and concentrations of E2, LH and PRL lowered in both groups after treating while treatment group improved more significant than control group in concentrations of T, E2 and PRL, the difference was notable(P＜0.05),LH in patients of both groups decreased notably and comparison between both groups demonstrated no remarkable difference (P＞0.05).Conclusion: Clinical effects of WenShen capsule and trazodone hydrochloride were superior to trazodone hydrochloride for depression complicated with ED.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期：2012-05-24 * 基金项目：甘肃省中医药管理局重点中医学课题(编号GZK-2010-Z10) 作者简介：彭晓明(1978—)，男，硕士学位。研究方向：精神神经疾病的临床及科研。 △通讯作者：陈林庆(1952—)，男，硕士研究生导师，教授，主任医师。研究方向：精神神经疾病的中西医结合防治。
更新日期/Last Update: 2012-11-15