[1]王思农,张娅茹,张博,等.三黄凝胶对大鼠耳廓痤疮模型血清IL-1α、TNF-α 的影响*[J].西部中医药,2013,26(01):7-8.
　WANG Sinong,ZHANG Yaru,ZHANG Bo,et al.Effects of SanHuang Gel on Serum IL-1α and TNF-α of Rats with Acne on the Auricle[J].Western Journal of Traditional Chinese Medicine,2013,26(01):7-8.
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三黄凝胶对大鼠耳廓痤疮模型血清IL-1α、TNF-α 的影响*()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年01期
页码:
7-8
栏目:
出版日期:
2013-01-15

文章信息/Info

Title:
Effects of SanHuang Gel on Serum IL-1α and TNF-α of Rats with Acne on the Auricle
文章编号:
1004-6852(2013)01-0007-02
作者:
王思农，张娅茹，张博，柳文红
甘肃中医学院，甘肃 兰州 730000
Author(s):
WANG Sinong, ZHANG Yaru, ZHANG Bo, LIU Wenhong
Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China
关键词:
三黄凝胶; 痤疮模型; IL-1α; TNF-α
Keywords:
SanHuang gel;  model with acne;  IL-1α;  TNF-α
分类号:
R758.73
文献标志码:
A
摘要:
目的：观察三黄凝胶对大鼠耳廓痤疮模型血清白介素 1α(IL-1α)、肿瘤坏死因子 α(TNF-α)含量的影响，探讨三黄凝胶治疗痤疮的作用机制。方法：采用 100%油酸于大鼠右耳廓皮内连续涂抹 3 周制造实验大鼠耳廓痤疮模型，造模成功后，模型组、正常组不涂抹任何药物，三黄凝胶高、中、低剂量组分别在大鼠右耳廓造模处涂抹不同剂量的三黄凝胶，阳性组涂抹 0.025%维 A 酸乳膏，连续治疗 2 周后，用双抗体夹心ABC-ELISA 法检测各组大鼠血清 IL-1α、TNF-α 的含量。结果：各治疗组大鼠血清 IL-1α、TNF-α 的含量均明显低于模型组(P＜0.05)，低、中剂量组与阳性组比较无统计差异(P＞0.05),高剂量组与阳性组比较有统计学意义(P＜0.05)。结论：三黄凝胶治疗痤疮的作用机制可能与抑制和减少 IL-1α、TNF-α 的产生有关。
Abstract:
Objective: To observe the effects of SanHuang gel on IL-1α and TNF-α in the serum of rats with acne on the auricle and explore its mechanism of SanHuang gel in treating acne. Method: Rat model with acne was established through smearing the auricle of right ears with 100% oleinic acid for three consecutive weeks. After successfully established the models, model group and normal group remained unhandled, SanHuang gel groups of high, moderate and low dose were spreaded with different doses of SanHuang gel over the right auricle, positive group were smeared with 0.025% tretinoin ointment. IL-1α and TNF-α in the serum of rats in all groups were detected with ABC-ELISA method after treating for two consecutive weeks. Result: Contents of serum IL-1琢 and TNF-琢 in the rats of different medicated groups were lower than that of model group remarkably (P ＜0.05),comparisons among moderate and low dose groups, positive group showed no difference (P＞0.05), comparison between high dose group and positive group demonstrated statistical meaning (P ＜0.05). Conclusion: The
mechanism of SanHuang gel in treating acne might be related to inhibiting and reducing the content of IL-1α and TNF-α.

参考文献/References:

［1］ American academy of dermatology.American academy of dermatology invitational symposium on comedogenicity［J］.J Am Acad Dermatol，1989，20：272-277.
［2］ 姜春明，葛蒙良.痤疮的发病机制研究进展［J］.皮肤病与性病，2003，25(3)：16-19.
［3］ 陈慰峰.医学免疫学［M］.北京：人民卫生出版社，2001：47.
［4］ Kupper TS，Groves RW.The interleukin-1 axis and cutaneous inflammation［J］.J Invest Dermatol，1995，105(1 Suppl)：62-66.

相似文献/References:

[1]郭斐斐,王思农,牛凡琪,等.三黄凝胶通过调控P38MAPK/ERK信号通路干预痤疮的作用机制[J].西部中医药,2022,35(09):28.[doi:10.12174/j.issn.2096-9600.2022.09.06]
　GUO Feifei,WANG Sinong,NIU Fanqi,et al.The Mechanism of Sanhuang Gel in Intervening Acne By Regulating P38MAPK/ERK Signaling Pathway[J].Western Journal of Traditional Chinese Medicine,2022,35(01):28.[doi:10.12174/j.issn.2096-9600.2022.09.06]

备注/Memo

备注/Memo:
收稿日期：2012-08-02
基金项目：甘肃省科技支撑计划(编号 1011FKCA124)
作者简介：王思农(1966—)，男，教授。研究方向：皮肤病及外科外用药物的临床及实验。
更新日期/Last Update: 2013-01-15