[1]徐家玥,许筠△,张茹,等.蛭龙胶囊对早期糖尿病肾病大鼠肾纤维化的影响*[J].西部中医药,2013,26(01):9.
 XU Jiayue,XU Jun,ZHA NG Ru,et al.Effects of ZhiLong Capsule on Renal Fibrosis of Rats with Early-stage Diabetic Nephropathy[J].Western Journal of Traditional Chinese Medicine,2013,26(01):9.
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蛭龙胶囊对早期糖尿病肾病大鼠肾纤维化的影响*()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年01期
页码:
9
栏目:
方药·药理研究
出版日期:
2013-01-15

文章信息/Info

Title:
Effects of ZhiLong Capsule on Renal Fibrosis of Rats with Early-stage Diabetic Nephropathy
文章编号:
1004-6852(2013)01-0009-03
作者:
徐家玥1许筠23△张茹4 李彩东2 翟晓丽23苏建平23
1 四川大学华西医院药剂科,四川 成都 610041;
2 兰州市第二人民医院;
3 甘肃省中医肾病医疗中心;
4 甘肃中医学院
Author(s):
 XU Jiayue1 XU Jun2 3△ ZHA NG Ru4 LI Caidong2 ZHA I Xiaoli23 SU Jianping23
1 Pharmacy Department in W est China Hospital of Sichuan University, Chengdu 610041, China;
2 Lanzhou Municipality Second People 忆s Hospital;
3 Gansu Provincial TCM Medical Center of Nephrosis;
4 Gansu University of Traditional Chinese Medicine
关键词:
蛭龙胶囊糖尿病肾病(DN)肾间质纤维化
Keywords:
ZhiLong capsule diabetic nephropathy (DN) renal interstitial fibrosis
分类号:
R587.1
文献标志码:
A
摘要:
目的:观察蛭龙胶囊对早期糖尿病肾病(DN)大鼠血清透明质酸(HA)、层黏连蛋白(LN)、Ⅲ型前胶原(PC-Ⅲ)、Ⅳ型胶原(Ⅳ-C)水平和肾脏病理形态学的影响。方法:采用高糖高脂饲料联合腹腔注射链尿佐菌素(STZ)45 mg/kg 的方法制备 DN 模型,分别以不同药物对模型鼠进行灌胃,采用放射免疫法测定各组大鼠血清 HA、LN、PC-Ⅲ和Ⅳ-C 水平,观察肾脏病理形态学的变化。结果:蛭龙胶囊组大鼠血清 HA、LN、PC-Ⅲ和Ⅳ-C降低,肾小球损害及肾间质纤维化程度减轻,与模型组相比差异有统计学意义(P<0.05)。结论:蛭龙胶囊能明显减轻 DN 模型大鼠肾小管间质病理损害,延缓肾间质纤维化的进展。
Abstract:
 Objective: To verify the effects of ZhiLong capsule on renal pathomorphology and contents of Ⅳ-C, PC-Ⅲ , LN and HA in the serum of rats with early-stage diabetic nephropathy(DN). Method: DN models were established with the method of high sugar and fat feed and peritoneal injection of STZ 45mg/kg, the models were given with intragastric administration of different drugs respectively. The contents of Ⅳ -C, PC-Ⅲ , LN and HA in the serum of rats were detected with radioimmunoassay to observe the changes of renal pathomorphology. Result: The contents of Ⅳ -C, PC-Ⅲ , LN and HA in the serum of rats in ZhiLong capsule group were decreased, glomerular damage and renal interstitial fibrosis were alleviated, it showed statistical meaning compared with the model group(P<0.05).Conclusion: ZhiLong capsule can remarkably relieve pathological lesions of renal tubular interstitial of the DN rat models and delay the development of renal interstitial fibrosis.

参考文献/References:

[1] 李平,谢院生.糖尿病肾病中西医结合研究基础与临床[M].上海:上海科学技术出版社,2009:168.
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[3] 郭啸华,刘志红,李恒,等.高糖高脂饮食诱导的 2 型糖尿病大鼠模型及其肾病特点[J].中国糖尿病杂志,2002,10(5):290-294.
[4] 杨亦彬,张翥,苏克亮,等.链脲佐菌素诱导大鼠糖尿病肾病模型的方法学探讨[J].华西医学,2005,20(2):299-300.
[5] 胡兴荣,崔显念,徐先早.糖尿病肾病 HA、LN、PCⅢ、Ⅳ-C 检测及其临床意义[J].检验医学与临床,2007,4(3):168-169.
[6] Fine LG,Bandyopadhay D,Norman JT,et al.Is there a common mechanism for the progression of different types of renal diseases other than proteinuria?towards the unifying theme of chronic hypoxia[J].Kidney Int,2000,57:S22-S26.
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[8] 潘贺,刚宏林,苏云明.中药水蛭的活性成分及药理作用研究概况[J].中医药信息,2006,23(1):20-22.
[9] 许筠,张少山,程保智,等.测定血清透明质酸、层粘蛋白等对肾纤维化诊断的意义[J].兰州大学学报:医学版,2011,37(4):24-27.

相似文献/References:

[1]胡晓文,李桂霞,俞徽,等.蛭龙胶囊对糖尿病肾病V期患者微炎症指标的影响[J].西部中医药,2017,30(04):88.
 HU Xiaowen,LI Guixia,YU Hui,et al.The Influence of ZhiLong Capsule on Micro Inflammation Indexes of Patients with Diabetic Nephropathy in V Stage[J].Western Journal of Traditional Chinese Medicine,2017,30(01):88.

备注/Memo

备注/Memo:
 收稿日期:2012-11-27
* 基金项目:甘肃省中医药管理局项目(编号 2007-GZK-28)
作者简介:徐家玥(1988—),女,药师。研究方向:临床药理。
△通讯作者:许筠(1963—),女,硕士研究生导师,主任医师,兼任中华中医药学会肾病分会副主任委员,甘肃省中医药学会副会长,甘肃省中西医结合学会常务理事,甘肃省中医药学会肾病
专业委员会主任委员,甘肃省医学会肾病专业委员会副主任委员,甘肃省中西医结合学会肾病专业委员会副主任委员,甘肃省中西医结合学会糖尿病专业委员会委员,甘肃省医师协会理事,兰州
市中医学会会长,《西部中医药》编委。研究方向:肾脏疾病的中西医结合诊治。
更新日期/Last Update: 2013-01-15