[1]张涛,景明△.归芪通便颗粒的质量标准研究*[J].西部中医药,2013,26(03):31-33.
 ZHANG Tao,JING Ming,Study on Quality Standard of GuiQi TongBian Granules[J].Western Journal of Traditional Chinese Medicine,2013,26(03):31-33.
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归芪通便颗粒的质量标准研究*
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年03期
页码:
31-33
栏目:
方药·质量分析
出版日期:
2013-03-15

文章信息/Info

Title:
Study on Quality Standard of GuiQi TongBian Granules
文章编号:
1004-6852(2013)03-0031-03
作者:
张涛1景明12△
1 甘肃中医学院,甘肃 兰州 730000;2 甘肃省中药药理与毒理学重点实验室
Author(s):
ZHANG Tao1 JING Ming1 2△
1 Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China; 2 Key Laboratory of Pharmacology and Toxicology for Traditional Chinese Medicines of Gansu Province
关键词:
归芪通便颗粒薄层色谱法高效液相色谱法质量标准
Keywords:
GuiQi TongBian granule thin-layer chromatography (TLC) high performance liquid chromatography (HPLC) quality standard
分类号:
R284
文献标志码:
A
摘要:
目的:建立归芪通便颗粒的质量控制方法。方法:采用薄层色谱法对归芪通便颗粒中的当归、枳实、白术进行定性鉴别;采用高效液相色谱法对制剂中所含何首乌的 2,3,5,4'- 四羟基二苯乙烯 -2-O-β-D 葡萄糖苷进行含量测定。结果:鉴别项下的阴性对照无干扰,专属性强;2,3,5,4'- 四羟基二苯乙烯 -2-O-β-D 葡萄糖苷在 0.523-2.461μg/mL 范围内呈良好的线性关系,相关系数 r=0.999 8,平均回收率(n=6)为 96.99%,RSD=0.67%。结论:该法操作简便、结果准确,重现性好,可用于归芪通便颗粒的质量控制。
Abstract:
Objective: To build the quality control method of GuiQi TongBian granules. Method: DangGui (Angelica sinensis), ZhiShi (Fructus Aurantii Immaturus) and BaiZhu (Rhizoma Atractylodis Macrocephalae) were detected qualitatively in the GuiQi TongBian granules with thin-layer chromatography (TLC); extract of HeShouWu (Radix Polygoni Multiflori) was tested with HPLC. Result: The identification was exclusive and the negative control had no interference; extract of HeShouWu showed a good linear relationship in the range of 0.523 to 2.461μg/mL,r=0.999 8, average recovery rate was 96.99% (n=6), RSD=0.67%. Conclusion: The method, simple, accurate and reproducible, could be used in quality control of GuiQi TongBian granules.

参考文献/References:

[1] 刘喜平,张涛,景明,等.归芪通便颗粒治疗功能性便秘的临床研究[J].西部中医药,2012,25(3):71-72. [2] 国家药典委员会.中华人民共和国药典[M].北京:中国医药科技出版社,2010:124. [3] 祁红,刘传统.定眩颗粒质量标准研究[J].中国药业,2012,21(3):16-17. [4] 刘振华,何丽果,徐艳霞.枳实消痞丸的薄层色谱鉴别[J].中国药物,2010,19(10):48. [5] 叶燕,程雪梅,俞桂新.白术药材的薄层色谱研究[J].时珍国医国药,2009,20(7):1702-1703. [6] 李艳,胡红艳,黄秋明.白术护肝合剂中当归、白术、芍药的薄层色谱鉴别[J].中医学报,2012,27(3):343-344. [7] 徐绍新,石召华,向阳,等.不同干燥工艺对何首乌提取物中二苯乙烯苷含量的影响[J].中成药,2007,29(11):1694-1695. [8] 朱培芳,赵荣华,施扬宪.HPLC 法同时测定何首乌中二苯乙烯苷和 5 种蒽醌类化合物的方法[J].中华中医药杂志,2012,27(2):463-465.

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备注/Memo

备注/Memo:
收稿日期:2012-09-28 * 基金项目:甘肃省定西市科技发展计划项目(2009-10-2) 作者简介:张涛(1987—),女,硕士研究生。研究方向:中药制剂工艺研究。 △通讯作者:景明(1963—),男,教授。研究方向:中药新药开发与研究。
更新日期/Last Update: 2013-03-15