[1]阎立新,蔺兴遥.安神利眠冲剂的药效学实验研究[J].西部中医药,2013,26(07):12-13.
　YAN Lixin,LIN Xingyao.Experimental Study on the Pharmacodynamics of AnShen LiMian Granules[J].Western Journal of Traditional Chinese Medicine,2013,26(07):12-13.
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安神利眠冲剂的药效学实验研究

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年07期
页码:
12-13
栏目:
出版日期:
2013-07-15

文章信息/Info

Title:
Experimental Study on the Pharmacodynamics of AnShen LiMian Granules
文章编号:
1004-6852(2013)07-0012-02
作者:
阎立新1，蔺兴遥2
1 兰州大学第二医院，甘肃 兰州 730030； 2 甘肃中医学院
Author(s):
YAN Lixin1, LIN Xingyao2
1 The Second Hospital of Lanzhou University, Lanzhou 730030, China; 2 Gansu University of Traditional Chinese Medicine
关键词:
安神利眠冲剂; 失眠症; 药效学; 毒理学; 实验研究
Keywords:
AnShen LiMian granules;  insomnia;  pharmacodynamics;  toxicology;  experimental study
分类号:
R28
文献标志码:
A
摘要:
目的：探讨安神利眠冲剂的疗效和安全性。方法：通过灌胃给予小鼠安神利眠冲剂，观察其对小鼠自主活动的影响，对戊巴比妥钠所致小鼠睡眠作用的影响，对戊四氮所致小鼠惊厥作用的影响及对小鼠的毒性反应。结果：安神利眠冲剂能使小鼠自主活动数明显减少，能增强戊巴比妥钠对小鼠的中枢抑制作用，可使戊四氮所致小鼠惊厥发生率明显降低，小鼠给药7天，未见不良反应，健康活泼，体质量增加，无1例死亡。结论：安神利眠冲剂具有镇静、催眠和抗惊厥作用，毒性低，使用安全。
Abstract:
Objective: To discuss clinical effects and safety of AnShen LiMian granules. Method: The effects of AnShen LiMian granules on autonomic activity of the mice, the sleep caused by pentobarbital sodium and convulsions induced by corazol and the toxicology were observed when the mice were administered with AnShen LiMian granules through intragastric administration. Result: AnShen LiMian granules could decrease the mice with autonomic activity, enhance the mice's Centre inhibition induced by pentobarbital sodium and lower the incidences of convulsions lead by corazol. The mice were administered with medicines for seven days, no side effects and death were found but vivacity and weight gained. Conclusion: AnShen LiMian granules are effective in sedation, hypnogenesis and anti-convulsions, which are safe with low toxicity.

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备注/Memo

备注/Memo:
收稿日期：2013-03-13 *基金项目：甘肃省科技攻关项目(编号ZGS042-A43-014-13) 作者简介：阎立新(1969—)，男，副主任医师，讲师。研究方向：精神心理疾病的临床及教学。
更新日期/Last Update: 2013-07-15