[1]贡布东智,阿召,何强,等.藏药“五味麝香丸”药效学实验研究[J].西部中医药,2013,26(08):55-57.
 GONGBU Dongzhi,A Zhao,HE Qiang,et al.Experimental Study on the Pharmacodynamics of Tibetan Drug “WuWei SheXiang Pill"[J].Western Journal of Traditional Chinese Medicine,2013,26(08):55-57.
点击复制

藏药“五味麝香丸”药效学实验研究
分享到:

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年08期
页码:
55-57
栏目:
专题·民族医药
出版日期:
2013-08-15

文章信息/Info

Title:
Experimental Study on the Pharmacodynamics of Tibetan Drug “WuWei SheXiang Pill"
文章编号:
1004-6852(2013)08-0055-03
作者:
贡布东智1阿召1何强2任远3马骏3吴国泰3
1甘南州藏医药研究院,甘肃 甘南 747000; 2 甘南佛阁藏药有限公司; 3 甘肃中医学院
Author(s):
GONGBU Dongzhi1 A Zhao1 HE Qiang2 REN Yuan3 MA Jun3 WU Guotai3
1 Gannan Tibetan Autonomous Prefecture Academy of Tibetan Medicine, Gannan 747000, China; 2 Gannan Tibetan Autonomous Prefecture Foge Tibetan Medicine Company LTD; 3 Gansu University of Traditional Chinese Medicine
关键词:
五味麝香丸抗炎镇痛大鼠小鼠
Keywords:
WuWei SheXiang pill anti-inflammation analgesia rats mice
分类号:
R285.5
文献标志码:
A
摘要:
目的:观察五味麝香丸对模型动物的抗炎镇痛作用。方法:制造大鼠、小鼠炎症模型和疼痛模型,观察五味麝香丸的抗炎镇痛作用。结果:五味麝香丸0.021 g/kg和0.010 g/kg两个剂量对组织胺所致大鼠足趾肿胀有明显抑制作用,与对照组相比差异有统计学意义(P<0.05);五味麝香丸0.030 g/kg和0.015g/kg两个剂量组对二甲苯所致小鼠耳壳肿胀和冰醋酸所致小鼠腹腔毛细血管通透性增加有明显抑制作用,与对照组相比差异有统计学意义(P<0.05)。五味麝香丸0.030 g/kg和0.015 g/kg两个剂量组对冰醋酸所致小鼠扭体反应有明显抑制作用,与对照组相比差异有统计学意义(P<0.01);五味麝香丸0.030 g/kg剂量组对小鼠热板痛阈值有明显提高作用,其作用在给药后60分钟和90分钟时较明显,与对照组相比差异有统计学意义(P<0.05)。结论:五味麝香丸具有明显的抗炎和镇痛作用。
Abstract:
Objective: To explore the anti-inflammation and analgesia actions of WuWei SheXiang pills on the animal models. Method: The rats and mice models suffering from inflammation and pain were established through observing the effects of WuWei SheXiang pills. Result: WuWei SheXiang pills showed the inhibition to toe swollen induced by histamine at the doses of 0.021g/kg and 0.010 g/kg obviously, the difference had statistical meaning compared with the control group (P<0.05); it also could inhibit ear-swollen caused by dimethylbenzene and the increase of capillary vessel permeability induced by glacial acetic acid remarkably at the doses of 0.030g/kg and 0.015g/kg, the differences had statistical meaning compared with the control group (P<0.05). The results of analgesia tests demonstrated that the drug could also inhibit the writhing test of the mice induced by acetic acid at the doses of 0.030 g/kg and 0.015 g/kg, the differences had statistical meaning compared with the control group(P<0.01); it could improve hot-plate threshold of the mice at the dose of 0.030 g/kg, it took effects in 60 minutes and 90 minutes after medication notably, the differences had statistical meaning compared with the control group (P<0.05). Conclusion: WuWei SheXiang pills show the function of better anti-inflammation and analgesia.

相似文献/References:

[1]史巧霞,王瑞琼,杜丽东.黄芩苷铈、钇配合物的镇痛抗炎作用研究[J].西部中医药,2013,26(06):13.
 SHI Qiaoxia,WANG Ruiqiong,DU Lidong.Anti-Inflammatory and Analgesic Study of Baicalin-cerium and Baicalin-yttrium[J].Western Journal of Traditional Chinese Medicine,2013,26(08):13.
[2]林清,高秀娟,喇孝瑾,等.秦艽醇提取物抗炎镇痛作用的实验研究[J].西部中医药,2013,26(07):28.
 LIN Qing,GAO Xiujuan,LA Xiaojin,et al.Experimental Study on Anti-inflammatory and Analgesic Effects of Ethanolic Extract of QinJiao[J].Western Journal of Traditional Chinese Medicine,2013,26(08):28.
[3]杨晔,焦正花,张小华,等.止痛膏抗炎镇痛和皮肤刺激性实验研究*[J].西部中医药,2014,27(03):26.
 YANG Ye,JIAO Zhenghua,ZHANG Xiaohua,et al.Study on Skin Irritation Experiments, Anti-inflammatory and Analgesic Effects of ZhiTong Ointment[J].Western Journal of Traditional Chinese Medicine,2014,27(08):26.
[4]杨维建,张超,李娟,等.伤科洁肤液的相关药理学实验研究[J].西部中医药,2015,28(10):25.
[5]谭超,安文蓉,刘娟,等.大柴胡汤中柴胡、大黄不同配比对抗炎镇痛作用的影响[J].西部中医药,2016,29(03):8.
 TAN Chao,AN Wenrong,LIU Juan,et al.HuangQin; body temperature; IL-1β; PGE2; genuine herbs[J].Western Journal of Traditional Chinese Medicine,2016,29(08):8.
[6]李跟旺,王 磊.秦艽在关节炎抗炎镇痛治疗中的作用[J].西部中医药,2018,31(03):133.
 LI Genwang,WANG Lei.Anti-inflammatory and Analgesic Effects of QinJiao in the Treatment for Arthritis[J].Western Journal of Traditional Chinese Medicine,2018,31(08):133.
[7]郭永福,张莉,刘汉斌,等.马铃薯喷雾剂对化疗性静脉炎小鼠的抗炎消肿作用[J].西部中医药,2020,33(01):29.[doi:10.12174/j.issn.1004-6852.2020.01.08]
 GUO Yongfu,ZHANG Li,LIU Hanbin,et al.A Study on Anti-inflammation and Detumescence Effects of Potato Sprays on the Mice with Chemotherapy-induced Phlebitis[J].Western Journal of Traditional Chinese Medicine,2020,33(08):29.[doi:10.12174/j.issn.1004-6852.2020.01.08]
[8]岳明,仝敏,卢健,等.对花仙宫血胶囊止血抗炎作用的实验研究[J].西部中医药,2020,33(06):17.[doi:10.12174/j.issn.1004-6852.2020.06.04]
 YUE Ming,TONG Min,LU Jian,et al.Experimental Study on Hemostatic and Anti-inflammatory Effects of Huaxian Gongxue Capsules[J].Western Journal of Traditional Chinese Medicine,2020,33(08):17.[doi:10.12174/j.issn.1004-6852.2020.06.04]
[9]孙晓春,雷莉妍,黄文静,等.北败酱提取物的体外抗氧化抗炎活性研究[J].西部中医药,2020,33(08):21.[doi:10.12174/j.issn.1004-6852.2020.08.06]
 SUN Xiaochun,LEI Liyan,HUANG Wenjing,et al.A Study on Antioxidant and Anti-inflammatory Activities of Extracts from Beibaijiang in Vitro[J].Western Journal of Traditional Chinese Medicine,2020,33(08):21.[doi:10.12174/j.issn.1004-6852.2020.08.06]

备注/Memo

备注/Memo:
收稿日期:2012-12-04 作者简介:贡布东智(1969—),男,副主任藏药师。研究方向:藏药的研究与开发。
更新日期/Last Update: 2013-08-15