[1]高军,任万明,指导:强志鹏.雷公藤多甙对银屑病患者NF-кB及细胞因子的影响[J].西部中医药,2013,26(09):26-28.
 GAO Jun,REN Wanming,Director: QIANG Zhipeng.Effects of Glucosidorum Tripterygii Tororum on NF-κB and Cytokines of Patients with Psoriasis[J].Western Journal of Traditional Chinese Medicine,2013,26(09):26-28.
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雷公藤多甙对银屑病患者NF-кB及细胞因子的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年09期
页码:
26-28
栏目:
方药·药理研究
出版日期:
2013-09-15

文章信息/Info

Title:
Effects of Glucosidorum Tripterygii Tororum on NF-κB and Cytokines of Patients with Psoriasis
文章编号:
1004-6852(2013)09-0026-03
作者:
高军任万明指导:强志鹏
兰州大学第一医院皮肤科,甘肃 兰州 730000
Author(s):
GAO Jun REN WanmingDirector: QIANG Zhipeng
Department of Dermatology in the First Hospital of Lanzhou University, Lanzhou 730000, China
关键词:
雷公藤多甙银屑病核因子
Keywords:
glucosidorum tripterygii tororum psoriasis nuclear factor
分类号:
R285.5
文献标志码:
A
摘要:
目的:探讨雷公藤多甙对核因子的影响并为药物治疗银屑病提供理论依据。方法:密度梯度离心法获得外周血单一核细胞(PBMC),体外培养角质形成细胞(KC)。PBMC与KC混合培养,流式细胞仪检测核转录因子κB(NF-κB)表达,ELISA法测上清液白介素-8(IL-8)、细胞间黏附分子-1(ICAM-1)含量。结果:银屑病组NF-κB表达及ICAM-1、IL-8含量与正常对照组间差异有显著性(P<0.01);雷公藤可下调NF-κB表达及IL-8、ICAM-1含量(P<0.01)。结论:雷公藤可能通过影响NF-κB的表达而发挥对银屑病的治疗作用,抑制NF-κB的药物可能有助于银屑病的治疗。
Abstract:
Objective: To explore the effects of glucosidorum tripterygii tororum on nuclear factor and provide theoretical evidence for treating psoriasis with drugs. Method: Peripheral blood mononuclear cells (PBMC) were obtained by density gradient centrifugation, and keratinocytes (KC) were cultured in vitro, PBMC and KC were mixed and cultured, the expressions of NF-κB were detected with flow cytometry and the contents of ICAM-1 and IL-8 in the liquid supernatant tested with ELISA method. Result: Psoriasis group showed significant difference compared with the normal control group in the expressions of NF-κB, the contents of ICAM-1 and IL-8(P<0.01); LeiGongTeng(tripterygium wilfordii) could lower the expressions of NF-κB and the contents of IL-8 and ICAM-1 (P<0.01). Conclusion: LeiGongTeng could improve the symptoms of psoriasis through influencing the expressions of NF-κB, drugs of inhibiting NF-κB might be helpful to the treatment of psoriasis.

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备注/Memo

备注/Memo:
收稿日期:2013-01-05 作者简介:高军(1971—),男,硕士学位,副主任医师。研究方向:银屑病的基础和临床研究。
更新日期/Last Update: 2013-09-15