[1]吴丽萍,李玉霞,尚菁,等.知柏地黄丸对性早熟模型大鼠FSH、T水平的影响*[J].西部中医药,2013,26(11):10-12.
 WU Liping,LI Yuxia,SHANG Jing,et al.Action of ZhiBai DiHuang Pill on the Levels of FSH and T of Rats with Sexual Precocity[J].Western Journal of Traditional Chinese Medicine,2013,26(11):10-12.
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知柏地黄丸对性早熟模型大鼠FSH、T水平的影响*
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年11期
页码:
10-12
栏目:
方药·药理研究
出版日期:
2013-11-15

文章信息/Info

Title:
Action of ZhiBai DiHuang Pill on the Levels of FSH and T of Rats with Sexual Precocity
文章编号:
1004-6852(2013)11-0010-03
作者:
吴丽萍1李玉霞1尚菁2吕晓武2
1甘肃中医学院附属医院,甘肃 兰州 730020; 2 甘肃中医学院
Author(s):
WU Liping1 LI Yuxia1 SHANG Jing2 LV Xiaowu2
1 University Hospital of Gansu Traditional Chinese Medicine, Lanzhou 730020, China; 2 Gansu University of Traditional Chinese Medicine
关键词:
性早熟知柏地黄丸卵泡刺激素血清睾酮大鼠
Keywords:
sexual precocity ZhiBai DiHuang pill follicle-stimulating hormone serum testosterone rat
分类号:
R285.5
文献标志码:
A
摘要:
目的:探讨知柏地黄丸对雌性真性性早熟大鼠垂体分泌的卵泡刺激素(FHS)、性腺分泌的睾酮(T)水平的影响。方法:将26日龄雌性SPF级SD大鼠50只随机分为5组,每组10只。采用N-甲基-D-天冬氨酸(NMDA)方法诱发建立性早熟动物模型,分别用放免法测定血清FSH、T水平。结果:模型组与空白组、知柏地黄丸大、中剂量组大鼠血清FSH及T水平比较,差异均有统计学意义(P<0.05),说明知柏地黄丸可降低性早熟大鼠血清FSH,T水平;小剂量组与大、中剂量组血清FSH,T水平比较,差异有统计学意义(P<0.05),说明知柏地黄丸调节性早熟大鼠血清FSH,T水平存在量效关系。结论:知柏地黄丸可抑制NMDA诱发雌性大鼠性早熟的发生及模型大鼠血清性激素FSH,T水平的表达。推测知柏地黄丸对模型大鼠下丘脑-垂体-性腺轴有调节作用。
Abstract:
Objective: To discuss the action of ZhiBai DiHuang pill on testosterone (T) and follicle-stimulating hormone (FSH) of rats suffering from sexual precocity. Method: All 50 rats were randomized into five groups, ten rats each group. Animal models were established by the method of N-methyl-D-aspartate (NMDA). The levels of T and FSH were detected through radioimmunoassay respectively. Result: The difference had statistical meaning in the levels of FSH and T from the comparison between model group and blank group, high dosage and low dosage groups of ZhiBai DiHuang pill(P<0.05). It demonstrated that ZhiBai DiHuang pill could lower the levels of T and FSH; the difference had statistical meaning in the levels of T and FSH when low dosage group was compared with high and moderate dosage groups of ZhiBai DiHuang pill(P<0.05), it presented that ZhiBai DiHuang pill and regulating the levels of T and FSH showed the dose-effect relationship. Conclusion: ZhiBai DiHuang pill could inhibit the incidence of sexual precocity in female rat caused by NMDA and the expressions of T and FSH of rat model. We speculate that ZhiBai DiHuang pill could regulate hypothalamic-pituitary-gonadal axis of model rat.

备注/Memo

备注/Memo:
收稿日期:2013-07-20 *基金项目:甘肃省中医药管理局科研基金资助项目(编号2007-CZK-40) 作者简介:吴丽萍(1962—),女,硕士研究生导师,主任医师。研究方向:小儿呼吸系统、内分泌系统疾病的中西医结合诊治。
更新日期/Last Update: 2013-11-15