[1]吴丽萍,李玉霞,尚菁,等.知柏地黄丸对性早熟模型大鼠FSH、T水平的影响*[J].西部中医药,2013,26(11):10-12.
WU Liping,LI Yuxia,SHANG Jing,et al.Action of ZhiBai DiHuang Pill on the Levels of FSH and T of Rats with Sexual Precocity[J].Western Journal of Traditional Chinese Medicine,2013,26(11):10-12.
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知柏地黄丸对性早熟模型大鼠FSH、T水平的影响*
《西部中医药》[ISSN:2096-9600/CN:62-1204/R]
- 卷:
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26
- 期数:
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2013年11期
- 页码:
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10-12
- 栏目:
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- 出版日期:
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2013-11-15
文章信息/Info
- Title:
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Action of ZhiBai DiHuang Pill on the Levels of FSH and T of Rats with Sexual Precocity
- 文章编号:
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1004-6852(2013)11-0010-03
- 作者:
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吴丽萍1,李玉霞1,尚菁2,吕晓武2
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1甘肃中医学院附属医院,甘肃 兰州 730020; 2 甘肃中医学院
- Author(s):
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WU Liping1, LI Yuxia1, SHANG Jing2, LV Xiaowu2
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1 University Hospital of Gansu Traditional Chinese Medicine, Lanzhou 730020, China;
2 Gansu University of Traditional Chinese Medicine
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- 关键词:
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性早熟; 知柏地黄丸; 卵泡刺激素; 血清睾酮; 大鼠
- Keywords:
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sexual precocity; ZhiBai DiHuang pill; follicle-stimulating hormone; serum testosterone; rat
- 分类号:
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R285.5
- 文献标志码:
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A
- 摘要:
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目的:探讨知柏地黄丸对雌性真性性早熟大鼠垂体分泌的卵泡刺激素(FHS)、性腺分泌的睾酮(T)水平的影响。方法:将26日龄雌性SPF级SD大鼠50只随机分为5组,每组10只。采用N-甲基-D-天冬氨酸(NMDA)方法诱发建立性早熟动物模型,分别用放免法测定血清FSH、T水平。结果:模型组与空白组、知柏地黄丸大、中剂量组大鼠血清FSH及T水平比较,差异均有统计学意义(P<0.05),说明知柏地黄丸可降低性早熟大鼠血清FSH,T水平;小剂量组与大、中剂量组血清FSH,T水平比较,差异有统计学意义(P<0.05),说明知柏地黄丸调节性早熟大鼠血清FSH,T水平存在量效关系。结论:知柏地黄丸可抑制NMDA诱发雌性大鼠性早熟的发生及模型大鼠血清性激素FSH,T水平的表达。推测知柏地黄丸对模型大鼠下丘脑-垂体-性腺轴有调节作用。
- Abstract:
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Objective: To discuss the action of ZhiBai DiHuang pill on testosterone (T) and follicle-stimulating hormone (FSH) of rats suffering from sexual precocity. Method: All 50 rats were randomized into five groups, ten rats each group. Animal models were established by the method of N-methyl-D-aspartate (NMDA). The levels of T and FSH were detected through radioimmunoassay respectively. Result: The difference had statistical meaning in the levels of FSH and T from the comparison between model group and blank group, high dosage and low dosage groups of ZhiBai DiHuang pill(P<0.05). It demonstrated that ZhiBai DiHuang pill could lower the levels of T and FSH; the difference had statistical meaning in the levels of T and FSH when low dosage group was compared with high and moderate dosage groups of ZhiBai DiHuang pill(P<0.05), it presented that ZhiBai DiHuang pill and regulating the levels of T and FSH showed the dose-effect relationship. Conclusion: ZhiBai DiHuang pill could inhibit the incidence of sexual precocity in female rat caused by NMDA and the expressions of T and FSH of rat model. We speculate that ZhiBai DiHuang pill could regulate hypothalamic-pituitary-gonadal axis of model rat.
备注/Memo
- 备注/Memo:
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收稿日期:2013-07-20
*基金项目:甘肃省中医药管理局科研基金资助项目(编号2007-CZK-40)
作者简介:吴丽萍(1962—),女,硕士研究生导师,主任医师。研究方向:小儿呼吸系统、内分泌系统疾病的中西医结合诊治。
更新日期/Last Update:
2013-11-15