[1]唐莉,姚婧,郭立中△.解酒护肝方对不同体质大鼠酒精性肝损伤的保护作用[J].西部中医药,2014,27(02):17-19.
 TANG Li,YAO Jing,GUO Lizhong.Study on the Protection of JieJiu HuGan Prescription against Alcoholic Liver Injury of Rats in Different Constitutions[J].Western Journal of Traditional Chinese Medicine,2014,27(02):17-19.
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解酒护肝方对不同体质大鼠酒精性肝损伤的保护作用
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《西部中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
27
期数:
2014年02期
页码:
17-19
栏目:
方药·药理研究
出版日期:
2014-02-15

文章信息/Info

Title:
Study on the Protection of JieJiu HuGan Prescription against Alcoholic Liver Injury of Rats in Different Constitutions
文章编号:
1004-6852(2014)02-0017-03
作者:
唐莉1姚婧1郭立中2△
1 南京中医药大学第一临床医学院,江苏 南京 210023; 2 南京中医药大学急难症研究所
Author(s):
TANG Li1 YAO Jing1 GUO Lizhong2△
1 The First Medical School in Nanjing University of Chinese Medicine, Nanjing 210023, China; 2 Emergency Institute of Nanjing University of Chinese Medicine
关键词:
解酒护肝方体质阳虚阴虚酒精性肝损伤
Keywords:
JieJiu HuGan prescription constitution Yang deficiency Yin deficiency alcoholic liver injury
分类号:
R285.5
文献标志码:
A
摘要:
目的:观察解酒护肝方对不同体质大鼠酒精性肝损伤的保护作用。方法:将大鼠随机分为正常组、阳虚模型组、阳虚预防给药组(温低组、温高组、寒低组、寒高组)、阴虚模型组、阴虚预防给药组(寒低组、寒高组、温低组、温高组)等11组,除正常组外,阳虚组采用30 mg/kg肌注氢化可的松,阴虚组采用甲状腺素水溶液25 mg/kg 分别建立阳虚模型、阴虚模型,造模完成后针对体质预防给药,分高、低剂量组(按生药量计为4.15,0.83 g/kg),1小时后灌胃0.009 mL/g 56度红星二锅头,持续灌注5周后测定大鼠血清谷草转氨酶(AST)、谷丙转氨酶(ALT)水平。结果:与正常组比较,模型组与预防给药组的AST、ALT及AST/ALT比值均增高,提示有不同程度的肝损伤(P<0.05);违背体质用药的高剂量组血清AST、ALT增高明显(P<0.05);符合体质用药的高剂量组血清AST、ALT明显降低(P<0.05)。结论:针对体质的解酒护肝方能有效预防大鼠酒精性肝损伤。
Abstract:
Objective: To observe the protective effects of JieJiu HuGan prescription on alcoholic liver injury of rats with different constitutions. Methods: All therats were randomized into 11 groups: normal group, Yang deficiency model group, medication groups of preventing Yang deficiency (low dose group of warm-nature prescription, high dose group of warm-nature prescription, low dose group of cold-nature prescription and high dose group of cold-nature prescription), Yin deficiency model group, medication groups of preventing Yin deficiency (low dose group of warm-nature prescription, high dose group of warm-nature prescription, low dose group of cold-nature prescription and high dose group of cold-nature prescription), except normal groups, the models of Yang deficiency were established by muscular injection of hydrocortisone (30 mg/kg) and the ones of Yin deficiency by intragastric administration of thyroxine aqueous solution(25 mg/kg). According to the constitutions, the rat models were given with preventive medicine in different dosages (4.15, 0.83 g/kg, intragastric administration), after one hour, the rats were perfused with Erguotou(112 degrees proof, 0.009 mL/g), the levels of AST and ALT in the serum of the rats were detected after perfused for five consecutive weeks. Results: Compared with the normal group, AST, ALT and AST/ALT of the model group and the preventive medication groups were increased, which suggested liver injury in different degrees (P<0.05); AST and ALT were improved significantly in the high dosage group which were medicated against the constitution(P<0.05); AST and ALT were decreased remarkably in the high dosage group which were medicated based on the constitution(P<0.05). Conclusion: JieJiu HuGan prescription based on the constitution could effectively prevent alcoholic liver injury of the rats.

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备注/Memo

备注/Memo:
收稿日期:2013-03-27作者简介:唐莉(1989—),女,硕士研究生。研究方向:消化系统疾病的中医诊治。△通讯作者:郭立中(1962—),男,博士研究生导师,教授,主任医师,江苏省中医学会急诊医学分会副主任委员。研究方向:内科急症及疑难病的中医诊治。
更新日期/Last Update: 2014-02-15