[1]赵成国,秦书芝,毛晶磊,等.瑶宝克癌灵胶囊抗肿瘤作用机制研究[J].西部中医药,2014,27(05):7-9.
　ZHAO Chengguo,QIN Shuzhi,MAO Jinglei,et al.Investigation on Anti-tumor Mechanism of YaoBao KeAiLing Capsules[J].Western Journal of Traditional Chinese Medicine,2014,27(05):7-9.
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瑶宝克癌灵胶囊抗肿瘤作用机制研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
27
期数:
2014年05期
页码:
7-9
栏目:
出版日期:
2014-05-15

文章信息/Info

Title:
Investigation on Anti-tumor Mechanism of YaoBao KeAiLing Capsules
文章编号:
1004-6852(2014)05-0007-03
作者:
赵成国1，秦书芝1，毛晶磊2，吴丽艳1，肖洪彬3△
1 吉林大学珠海学院，广东 珠海 519041； 2 大庆油田总医院； 3 黑龙江中医药大学
Author(s):
ZHAO Chengguo1, QIN Shuzhi1, MAO Jinglei2, WU Liyan1, XIAO Hongbin3△
1 Zhuhai College of Jilin University, Zhuhai 519041, China; 2 Daqing Oilfield General Hospital; 3 Heilongjiang University of Chinese Medicine
关键词:
瑶宝克癌灵胶囊; IL-2; IFN-γ; p53; Bcl-2
Keywords:
YaoBao KeAiLing capsules;  IL-2;  IFN-γ;  p53;  Bcl-2
分类号:
R273.5
文献标志码:
A
摘要:
目的：从分子生物学角度探讨瑶宝克癌灵胶囊抗肿瘤的作用机理。方法：采用双抗体夹心ELISA法检测S180荷瘤小鼠外周血白细胞介素-2（IL-2）、γ-干扰素（IFN-γ）的含量；采用免疫组化法检测凋亡相关基因突变型p53和Bcl-2基因的表达。结果：瑶宝克癌灵胶囊可明显增加小鼠外周血IL-2、IFN-γ的含量，可抑制突变型基因p53和Bcl-2基因的表达。结论：瑶宝克癌灵胶囊抗肿瘤的作用机制可能与增强荷瘤小鼠免疫功能，抑制突变型基因p53和Bcl-2基因的表达有关。
Abstract:
Objective: To explore anti-tumor mechanism of YaoBao KeAiLing capsules with molecular biology. Methods: The contents of interleukin-2 (IL-2) and interferon-γ (IFN-γ) were detected with double antibody sandwich ELISA method; the expressions of Bcl-2 gene and p53 were measured by immunohistochemical method. Results: YaoBao KeAiLing capsules could increase the contents of IL-2 and IFN-γ in peripheral blood of mice, inhibit the expressions of p53 and Bcl-2. Conclusion: Anti-tumor mechanism of YaoBao KeAiLing capsules might be related to increasing the immunity of the mice, inhibiting the expressions of p53 and Bcl-2.

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备注/Memo

备注/Memo:
收稿日期：2013-10-10作者简介：赵成国(1978—)，男，硕士研究生，讲师。研究方向：中药药理学研究。△通讯作者：肖洪彬(1957—)，男，博士后合作导师，博士研究生导师，教授。研究方向：方剂配伍规律及方剂疗效客观化的研究。
更新日期/Last Update: 2014-05-15