[1]罗向霞,张定华,史晓伟,等.糖网康对非增殖期糖尿病视网膜功能保护作用的实验研究*[J].西部中医药,2014,27(08):11-13.
 LUO Xiangxia,ZHANG Dinghua,SHI Xiaowei,et al.Experimental Study on TangWangKang Protecting Retinal Function of the Patients with Diabetes Mellitus at Non-proliferation Phase[J].Western Journal of Traditional Chinese Medicine,2014,27(08):11-13.
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糖网康对非增殖期糖尿病视网膜功能保护作用的实验研究*
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
27
期数:
2014年08期
页码:
11-13
栏目:
方药·药理研究
出版日期:
2014-08-15

文章信息/Info

Title:
Experimental Study on TangWangKang Protecting Retinal Function of the Patients with Diabetes Mellitus at Non-proliferation Phase
文章编号:
1004-6852(2014)08-0011-03
作者:
罗向霞12张定华12史晓伟12路雪婧3
1 甘肃中医学院第一附属医院,甘肃 兰州 730050; 2 甘肃省中医院; 3 成都中医药大学眼科实验室
Author(s):
LUO Xiangxia12 ZHANG Dinghua12 SHI Xiaowei12 LU Xuejing3
1 University Hospital of Gansu Traditional Chinese Medicine, Lanzhou 730050, China; 2 Gansu Provincial Hospital of Traditional Chinese Medicine; 3 Lab of Ophthalmology of Chengdu University of TCM
关键词:
糖网康视网膜电图糖尿病视网膜病变
Keywords:
TangWangKang electroretinogram diabetic retinopathy
分类号:
R587.2
文献标志码:
A
摘要:
目的:探讨糖网康对视网膜功能的保护作用。方法:将40只自发性糖尿病GK大鼠随机分为4组:模型对照组、糖网康低、中、高剂量组,各组分别灌胃2 mL蒸馏水、150 mg/kg糖网康、300 mg/kg糖网康、600 mg/kg糖网康。每日灌胃1次,连续给药1个月,记录大鼠明视闪光视网膜电图(fERG)a波、b波和Ops波,并将数据统计分析。结果:用药后中药中高剂量组比其他各组用药后的a波、Ops波振幅提高,差异有显著的统计学意义,a波波峰潜时比较差异有统计学意义,潜时缩短;中药中低剂量组比其他各组的b波振幅提高,差异有统计学意义(P<0.05),b波峰潜时比较差异有统计学意义,潜时缩短。中药糖网康能提高糖尿病大鼠fERG的振幅,缩短潜时,尤其是对Ops干预作用明显。结论:中药糖网康对糖尿病模型的早期视网膜功能损害,尤其是视网膜内层血液循环状态的改善具有一定作用。
Abstract:
Objective: To discuss the function of TangWangKang on retinal function. Methods: Forty GK rats with spontaneous diabetes mellitus (DM) were randomized into four groups: model control group, low dosage group, moderate dosage group and high dosage group, all the groups above were perfused with distilled water, 2 mL, 150 mg/kg TangWangKang, 300 mg/kg TangWangKang, and 600 mg/kg TangWangKang, once per day, administered with the drugs for one month consecutively, a wave, b wave and Ops wave of flash electroretinogram (fERG) of the rats were recorded and analyzed statistically. Results: After the medication, herb groups of moderate and high dosage were higher than other groups in heightening the amplitudes of a wave and Ops wave, the difference showed notable statistical meaning, the difference showed statistical meaning in the peak latency of a wave, the latency was shortened; after the medication, herb group of moderate dosage was raised compared with other groups in increasing the amplitude of b wave, the difference showed statistical meaning (P<0.05), the difference showed statistical meaning in the peak latency of b wave, the latency was cut down. TangWangKang could significantly increase the amplitude of fERG of DM rats, cut down the latency, especially intervene Ops obviously. Conclusion: TangWangKang could improve early injury of retinal function in DM rat models, especially intimal blood circulation of retina in a certain degree.

备注/Memo

备注/Memo:
收稿日期:2014-03-05*基金项目:甘肃省高等学校科研资助项目,2011年度甘肃 省教育厅第二批科研项目计划(编号1106B-15)作者简介:罗向霞(1975—),女,博士学位,副主任医师。研究方向:眼底病的中医诊治。
更新日期/Last Update: 2014-08-15