[1]周立亚,刘德玉,李福林,等.热敷散外敷治疗兔骨性关节炎的机理研究[J].西部中医药,2014,27(10):22.
点击复制

热敷散外敷治疗兔骨性关节炎的机理研究
分享到:

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
27
期数:
2014年10期
页码:
22
栏目:
方药·药理研究
出版日期:
2014-10-15

文章信息/Info

作者:
周立亚1刘德玉2李福林3邹季1
1 湖北中医药大学针灸骨伤学院,湖北 武汉 430000; 2 陕西中医学院附属医院骨科;3 榆林市卫生学校附属医院
关键词:
骨关节炎热敷散白介素-β1肿瘤坏死因子-α
摘要:
目的:观察中药热敷散外敷治疗兔骨性关节炎模型的组织病理学变化及关节冲洗液中白介素-β1(IL-β1)与肿瘤坏死因子-α(TNF-α)的变化,探讨热敷散对兔骨性关节炎的疗效及其作用机理。方法:采用兔膝关节腔内注射木瓜蛋白酶的方法,建立兔骨性关节炎模型:将30只日本大耳白兔随机分为空白对照组(A组,n=10)、模型对照组(B组,n=10)、热敷散组(C组,n=10)。造模后1周,在3组动物中各随机抽取1只实验动物,空气栓塞法处死后进行患膝关节病理观察,明确造模是否成功。A组每天热水袋热敷膝关节2次;B组造模成功后每天热水袋热敷膝关节2次;C组造模成功后,每天用热敷散热敷治疗2次。在治疗4周后,空气栓塞法处死动物,抽取膝关节液后,切开兔的膝关节,观察膝关节股骨髁关节面大体病理变化及股骨髁关节软骨病理变化,并检测关节冲洗液中IL-β1与TNF-α含量的变化。结果:①在造模成功,给予3组实验动物相应治疗4周后处死实验动物,抽取膝关节液后,做病理观察见A组动物关节及关节软骨正常;B、C组动物关节肿胀,关节软骨面破坏。②B、C组动物关节冲洗液中IL-β1和TNF-α的含量明显高于A组(P<0.05),同时C组动物关节冲洗液中IL-β1和TNF-α的含量明显低于B组(P<0.05)。结论:热敷散能通过降低关节液中IL-β1和TNF-α的含量进而起到对骨关节炎的治疗作用。

相似文献/References:

[1]张建林.中药熏洗联合关节内注射玻璃酸钠治疗膝骨关节炎30例疗效观察[J].西部中医药,2012,25(09):80.
 ZHANG Jian-lin.Curative Observation on Fumigation with Herb and Intra-Articular Sodium Hyaluronate Injection in Treating 30 Cases of Knee Osteoarthritis[J].Western Journal of Traditional Chinese Medicine,2012,25(10):80.
[2]王亚伟,张彦军.中西医综合治疗膝骨性关节炎疗效观察[J].西部中医药,2012,25(05):80.
 WANG Ya-wei,ZHANG Yan-jun.Observation on Comprehensive Treatment of Knee Osteoarthritis with Integrated Traditional Chinese and Western Medicine[J].Western Journal of Traditional Chinese Medicine,2012,25(10):80.
[3]薄云,赵丽艳,李淑贤,等.疏肝滋肾汤治疗女性腰椎骨性关节炎40例[J].西部中医药,2017,30(02):79.
 BO Yun,ZHAO Liyan,LI Shuxian,et al.ShuGan ZiShen Tang in Treating 40 Cases of Female Lumbar Osteoarthritis[J].Western Journal of Traditional Chinese Medicine,2017,30(10):79.
[4]孙雪莲,刘渊△.从中医“肾主骨”理论出发防治骨关节炎[J].西部中医药,2016,29(03):48.
 SUN Xuelian,LIU Yuan.The Prevention and the Treatment of Osteoarthritis Based on the Theory of TCM ″Kidney Governing Bone″[J].Western Journal of Traditional Chinese Medicine,2016,29(10):48.
[5]薄云,夏冰杰,赵丽艳,等.疏肝滋肾汤治疗绝经后女性骨关节炎的临床观察[J].西部中医药,2016,29(07):93.
 BO Yun,XIA Bingjie,ZHAO Liyan,et al.Clinical Observation on ShuGan ZiShen Tang in Osteoarthritis of the Female Patients after the Menopause[J].Western Journal of Traditional Chinese Medicine,2016,29(10):93.
[6]刘红喜,李盛华,毕军伟,等.陇中骨刺膏治疗膝关节骨关节炎96例疗效观察[J].西部中医药,2017,30(03):46.
 LIU Hongxi,LI Shenghua,BI Junwei,et al.Effects Observation on LongZhong GuCi Ointment in Treating 96 Cases of Knee Osteoarthritis[J].Western Journal of Traditional Chinese Medicine,2017,30(10):46.
[7]李浩炜,张静,敬胜伟,等.密集型银质针与电针治疗膝骨关节炎疗效观察[J].西部中医药,2018,31(01):105.
 LI Haowei,ZHANG Jing,JING Shengwei,et al.Observation on the Effects of Intensive Silver Needles and Acusector in Treating Knee Osteoarthritis[J].Western Journal of Traditional Chinese Medicine,2018,31(10):105.
[8]王兴昌.小针刀治疗膝骨性关节炎50例[J].西部中医药,2017,30(08):139.
 WANG Xingchang.Small Needle-knife in Treating 50 Cases of Knee Osteoarthritis[J].Western Journal of Traditional Chinese Medicine,2017,30(10):139.
[9]李盛华,吴献毅,周明旺,等.细胞凋亡在膝骨性关节炎半月板损伤中的作用研究[J].西部中医药,2018,31(02):131.
 LI Shenghua,WU Xianyi,ZHOU Mingwang,et al.Research on the Roles of Cellular Apoptosis Played in Meniscus Injury of the Patients with Knee Osteoarthritis[J].Western Journal of Traditional Chinese Medicine,2018,31(10):131.
[10]刘朝辉,赵道洲,孔令俊,等.消定膏外敷治疗膝关节骨性关节炎60例[J].西部中医药,2018,31(04):81.
 LIU Zhaohui,ZHAO Daozhou,KONG Lingjun,et al.Treating 60 Patients with Knee Osteoarthritis by XiaoDing Ointment for External Application[J].Western Journal of Traditional Chinese Medicine,2018,31(10):81.

备注/Memo

备注/Memo:
作者简介:周立亚(1976—),男,博士研究生,副主任医师。研究方向:脊椎、关节疾病的中西医结合诊治。
更新日期/Last Update: 2014-10-15