[1]马毅,徐丽△,曹军平,等.白藜芦醇对糖尿病小鼠抗应激的实验研究[J].西部中医药,2014,27(12):15.
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白藜芦醇对糖尿病小鼠抗应激的实验研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
27
期数:
2014年12期
页码:
15
栏目:
方药·药理研究
出版日期:
2014-12-15

文章信息/Info

文章编号:
1004-6852(2014)12-0015-03
作者:
马毅徐丽△曹军平李霞孙慧萍李冬梅
武警总医院,北京 100039
关键词:
糖尿病白藜芦醇小鼠抗应激
分类号:
R285.5
文献标志码:
A
摘要:
目的:探讨白藜芦醇对糖尿病小鼠抗应激能力的影响。方法:四氧嘧啶腹腔注射造成小鼠糖尿病模型,分为白藜芦醇高、中、低剂量组(20、10、5 mg/kg),模型组,正常组。腹腔注射给药7天后,分别通过爬绳、负重游泳、耐缺氧、耐高/低温实验,评价白藜芦醇对小鼠应激能力的影响。结果:白藜芦醇各剂量组均可显著延长糖尿病小鼠的爬绳时间(5.2~6.9 min)、游泳耗竭时间(17.9~20.0 min)和常压耐缺氧下的生存时间(15.9~16.7 min),与模型组比较有统计学意义(P<0.05);白藜芦醇高、中剂量组可明显增强小鼠耐高温、耐低温能力(P<0.05),降低死亡率(P<0.05)。结论:白藜芦醇能提高糖尿病小鼠的抗应激能力。

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备注/Memo

备注/Memo:
作者简介:马毅(1970—),男,主管技师。研究方向:生物医学。△通讯作者:徐丽(1982—),女,主管药师。研究方向:临床药学。
更新日期/Last Update: 2014-12-15