[1]周明旺,王晓萍,李盛华,等.膝骨性关节炎中医体质类型与IGF-1表达的相关性研究[J].西部中医药,2015,28(12):1-3.
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膝骨性关节炎中医体质类型与IGF-1表达的相关性研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
28
期数:
2015年12期
页码:
1-3
栏目:
出版日期:
2015-12-15

文章信息/Info

文章编号:
1004-6852(2015)12-0001-03
作者:
周明旺1王晓萍1李盛华1郭铁峰1孙凤歧1穆欢喜2
1 甘肃省中医院,甘肃 兰州 730050;2 甘肃中医药大学
关键词:
关节炎骨性膝关节体质学说IGF-1阳虚质
分类号:
R363.2
文献标志码:
A
摘要:
目的:探讨膝骨性关节炎(KOA)中医体质类型与胰岛素生长因子-1(IGF-1)表达量的相关性,为中医药防治KOA提供新的思路和方法。方法:随机对161例确诊为KOA的患者进行中医体质类型问卷调查,签署知情同意书,按中医体质类型分为9组作为观察组;随机选取50例非血缘关系健康志愿者为对照组。采集观察组与对照组血清样本,用ELISA法测定样本中IGF-1的水平,采用SPSS 17.0软件统计分析。结果:在9种中医体质类型中,阳虚质KOA患者中IGF-1的表达水平明显低于对照组,差异有统计学意义(P<0.05)。特禀质与血瘀质均为0例,其他6种体质中IGF-1的表达水平与对照组比较,差异无统计学意义(P>0.05)。结论:IGF-1的表达水平降低与阳虚质KOA的发病具有相关性,TGF-β1表达异常可能是阳虚质易发KOA的分子生物学机制之一。

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备注/Memo

备注/Memo:
*基金项目:国家自然科学基金项目(编号81260546);甘肃省青年科技基金计划项目(编号1208RJYA4011);甘肃省教育厅项目(编号1106B-16)。作者简介:周明旺(1977—),男,博士学位,副主任医师。研究方向:中西医结合防治骨关节疾病。
更新日期/Last Update: 2015-12-15