[1]祁佳,张宇锋△.黄芪颗粒辅助治疗老年肺结核疗效观察及其对T淋巴细胞亚群的影响[J].西部中医药,2016,29(01):1-4.
　QI Jia,ZHANG Yufeng.Clinical Observation on Adjunctive Therapy in Treating Senile Pulmonary Tuberculosis by HuangQi Granules and Its Influence on Tlymphocyte Subsets[J].Western Journal of Traditional Chinese Medicine,2016,29(01):1-4.
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黄芪颗粒辅助治疗老年肺结核疗效观察及其对T淋巴细胞亚群的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
29
期数:
2016年01期
页码:
1-4
栏目:
出版日期:
2016-01-15

文章信息/Info

Title:
Clinical Observation on Adjunctive Therapy in Treating Senile Pulmonary Tuberculosis by HuangQi Granules and Its Influence on Tlymphocyte Subsets
文章编号:
1004-6852(2016)01-0001-04
作者:
祁佳1，张宇锋2△
1 上海交通大学附属新华医院，上海 200092； 2 南京中医药大学附属江阴市中医院
Author(s):
QI Jia1, ZHANG Yufeng2△
1 Xinhua Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200092, China;2 Jiangyin Hospital of TCM Affiliated to Nanjing University of Chinese Medicine
关键词:
老年肺结核; T淋巴细胞亚群; 细胞免疫; 黄芪颗粒
Keywords:
senile pulmonary tuberculosis;  T lymphocyte subsets;  cellular immunity;  HuangQi granules
分类号:
R52
文献标志码:
A
摘要:
目的:观察黄芪颗粒辅助治疗老年肺结核的疗效及对T淋巴细胞亚群的影响。方法:将老年肺结核患者50例随机分为治疗组（黄芪颗粒联合标准抗结核治疗）和对照组（标准抗结核治疗）各25例，将健康老年体检者20例作为正常对照组。观察治疗效果并检测外周血T淋巴细胞亚群。结果：2组治疗前CD3、CD4低于正常对照组,差异有统计学意义(P＜0.05)；治疗后治疗组CD3、CD4高于治疗前，差异有统计学意义(P＜0.05)；治疗后对照组CD3、CD4与治疗前比较差异无统计学意义(P＞0.05)；CD3、CD4治疗组与对照组治疗后比较,差异有统计学意义(P＜0.05)。治疗组和对照组痰菌转阴率、肺部病灶总吸收率、不良反应比较差异无统计学意义(P＞0.05)。结论:黄芪颗粒可调节T淋巴细胞亚群，增强老年性肺结核患者的细胞免疫功能，疗效较单纯使用标准抗结核治疗为佳。
Abstract:
Objective: To observe curative effects of HuangQi［Astrayalus membranaceus(Fisch.)Bunge.］ granules in adjunctive treatment of senile pulmonary tuberculosis and its influence on T lymphocyte subsets. Methods: Fifty patients were randomly divided into the treatment group (HuangQi granules combined with standard anti-tuberculosis therapy) and the control group(standard anti-tuberculosis therapy), 25 cases each group, other 20 healthy senile persons who accepted healthy examination were selected as normal control group. Clinical effects were observed and T lymphocyte subsets in peripheral blood were detected. Results: The treatment group and the control group were lower than normal control group in the levels of CD3 and CD4 before treating, the difference had statistical meaning (P＜0.05); the levels of CD3 and CD4 after treating were higher than these before treating, and the difference showed statistical meaning (P＜0.05); the difference presented no statistical meaning (P＞0.05) in the comparison of the levels of CD3 and CD4 in the control group between before and after treating (P＞0.05); the levels of CD3 and CD4 in the treatment group were higher than these of the control group after treating, and the difference demonstrated statistical meaning(P＜0.05). The difference had no statistical meaning (P＞0.05) in the comparison of sputum conversion rate, total absorption rate of pulmonary focus and adverse reactions between the treatment group and the control group. Conclusion: HuangQi granules can regulate T lymphocyte subsets and enhance cellular immunity of the patients with senile pulmonary tuberculosis. Its effects are better than these of only standard anti-tuberculosis therapy.

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备注/Memo

备注/Memo:
*基金项目：国家自然科学基金(编号81302768)。作者简介：祁佳(1984—)，男，硕士学位，药师。研究方向：中、西药药动学新方法及其关键技术。△通讯作者：张宇锋(1984—)，男，主治医师。研究方向：呼吸系统疾病的中西医结合诊治。
更新日期/Last Update: 2016-01-15