[1]范小芬,邓银泉,陈玖,等.非酒精性脂肪性肝病不同中医证型与血清TNF-α、IL-6水平的关系研究[J].西部中医药,2016,29(01):5-7.
　FAN Xiaofen,DENG Yinquan,CHEN Jiu,et al.Study on the Relationship between Different Patterns of Nonalcoholic Fatty Liver Disease and the Levels of TNF-α and IL-6[J].Western Journal of Traditional Chinese Medicine,2016,29(01):5-7.
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非酒精性脂肪性肝病不同中医证型与血清TNF-α、IL-6水平的关系研究()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
29
期数:
2016年01期
页码:
5-7
栏目:
出版日期:
2016-01-15

文章信息/Info

Title:
Study on the Relationship between Different Patterns of Nonalcoholic Fatty Liver Disease and the Levels of TNF-α and IL-6
文章编号:
1004-6852(2016)01-0005-03
作者:
范小芬，邓银泉，陈玖，吴国琳，李剑平
浙江大学医学院附属第一医院中医科，浙江 杭州 310003
Author(s):
FAN Xiaofen, DENG Yinquan, CHEN Jiu, WU Guolin, LI Jianping
TCM Department of The First Affiliated Hospital of Medical School of ZheJiang University, Hangzhou 310003, China
关键词:
非酒精性脂肪性肝病; TNF-α; IL-6; 中医证型
Keywords:
nonalcoholic fatty liver disease;  TNF-α;  IL-6;  patterns
分类号:
R575.15
文献标志码:
A
摘要:
目的：观察非酒精性脂肪性肝病（NAFLD）患者不同中医证型与血清肿瘤坏死因子-α（TNF-α）、白介素－6（IL-6）表达水平的关系，为NAFLD中医辨证分型提供客观参数。方法：将NAFLD患者130例按中医辨证分型标准分为5型，即脾虚湿痰证（32例）、肝郁脾虚证（30例）、痰瘀互结证（30例）、湿热内蕴证（34例）和肝肾不足证（4例，因样本数太少，未纳入统计分析），测定患者血清TNF-α、IL-6水平，并以同期不嗜酒的30名健康人为健康对照组进行比较。结果：NAFLD不同中医各证型患者血清TNF-α、IL-6水平均高于健康对照组，差异有统计学意义(P＜0.01)；血清TNF-α、IL-6水平在中医各证型间按脾虚湿痰证→肝郁脾虚证→痰瘀互结证→湿热内蕴证依次升高，湿热内蕴证患者血清TNF-α、IL-6水平高于其他三个证型(P＜0.05)；痰瘀互结型血清TNF-α、IL-6水平高于脾虚湿阻证、肝郁脾虚证(P＜0.05)，但肝郁脾虚与脾虚湿痰两证型比较未见明显差异(P＞0.05）。结论：NAFLD患者血清TNF-α、IL-6水平在不同中医证型间的表达存在差异性。
Abstract:
Objective: To provide objective reference for syndrome differentiation and treatment of nonalcoholic fatty liver disease (NAFLD) by observing the relationship between different patterns of NAFLD and the levels of TNF-α and IL-6. Methods: All 130 patients were classified into five types according to the standard of syndrome differentiation: spleen deficiency and dampness-phlegm (32 cases), liver depression and spleen deficiency (30 cases), intermingled phlegm and stagnation (30 cases), internal accumulation of dampness-heat (34 cases) and liver-kidney depletion (4 cases, not included in statistical analysis because of small sample size). The levels of TNF-α and IL-6 of the patients were detected, at the same time, 30 healthy people were chosen as the control group and compared with the other groups. Results: NAFLD patients of different patterns in the groups were higher than the control group in the levels of TNF-α and IL-6, and the difference had statistical meaning (P＜0.01); the levels of TNF-α and IL-6 raised gradually in the order of spleen deficiency and dampness-phlegm, liver depression and spleen deficiency, intermingled phlegm and stagnation and internal accumulation of dampness-heat, the patients of internal accumulation of dampness-heat pattern were higher than others in the levels of TNF-α and IL-6 (P＜0.05); intermingled phlegm and stagnation was higher than spleen deficiency and dampness-phlegm and liver depression and spleen deficiency in the levels of TNF-α and IL-6 (P＜0.05), but there was no obvious difference in the comparison between liver depression and spleen deficiency and spleen deficiency and dampness-phlegm (P＞0.05). Conclusion: The study shows that TNF-α and IL-6 express differently in NAFLD patients of different patterns.

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备注/Memo

备注/Memo:
作者简介：范小芬(1968—)，女，副主任医师。研究方向：肝病及代谢性疾病的诊治。
更新日期/Last Update: 2016-01-15