[1]陈小平,王志旺,刘彩民△,等.荣骨定痛膏对骨性关节炎大鼠IL-1β、NO及氧自由基代谢的影响[J].西部中医药,2016,29(07):23-26.
 CHEN Xiaoping,WANG Zhiwang,LIU Caimin,et al.The Influence of RongGu DingTong Ointments on IL-1β, NO and Oxygen Free Radical Metabolism of OA Rats[J].Western Journal of Traditional Chinese Medicine,2016,29(07):23-26.
点击复制

荣骨定痛膏对骨性关节炎大鼠IL-1β、NO及氧自由基代谢的影响
分享到:

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
29
期数:
2016年07期
页码:
23-26
栏目:
方药·药理研究
出版日期:
2016-07-15

文章信息/Info

Title:
The Influence of RongGu DingTong Ointments on IL-1β, NO and Oxygen Free Radical Metabolism of OA Rats
文章编号:
1004-6852(2016)07-0023-04
作者:
陈小平1王志旺2刘彩民1△妥海燕2王瑞琼2
1 靖远县中医院,甘肃 靖远 730600; 2 甘肃中医药大学
Author(s):
CHEN Xiaoping1 WANG Zhiwang2 LIU Caimin1△ TUO Haiyan2 WANG Ruiqiong2
1 Jingyuan County TCM Hospital, Jingyuan 730600, China; 2 Gansu University of Traditional Chinese Medicine
关键词:
骨性关节炎白介素1β一氧化氮抗氧化系统荣骨定痛膏
Keywords:
osteoarthritis IL-1β NO antioxidant system RongGu DingTong ointment
分类号:
R684.3
文献标志码:
A
摘要:
目的:探讨荣骨定痛膏对骨性关节炎模型大鼠白介素1β(IL-1β)、一氧化氮(NO)及氧自由基代谢的影响。方法:采用注射4%木瓜蛋白酶复制骨性关节炎大鼠模型,通过观测膝关节功能,血清IL-1β、关节液NO与NOS、关节组织氧自由基代谢等指标,探讨荣骨定痛膏对骨性关节炎的治疗作用及作用机制。结果:荣骨定痛膏可明显减小骨性关节炎大鼠关节滑膜肿胀厚度,扩大膝关节的活动范围,降低血清IL-1β、关节液NO及NOS的水平,提高滑膜组织中SOD的活性而降低MDA的含量。结论:荣骨定痛膏对骨性关节炎模型大鼠具有一定治疗作用,抑制IL-1β诱导的NO的产生而发挥抗氧化、抑制滑膜细胞的凋亡是其治疗骨性关节炎的作用机制之一。
Abstract:
Objective: To discuss the effects of RongGu DingTong ointment on IL-1β, NO and oxygen free radical metabolism of the rats with osteoarthritis(OA). Methods: OA rat model was established by injecting 4% papain, therapeutic effects and its mechanism of RongGu DingTong ointment were studied by observing knee joint function, the contents of IL-1β, NO and NOS, and oxygen free radical metabolism in joint tissue. Results: RongGu DingTong ointment could reduce the thickness of joint synovial swelling of OA rats, increase the range of motion of knee joint, decrease the levels of IL-1β, NO and NOS, and improving SOD activity in synovial tissue therefore to decrease the contents of MDA. Conclusion: RongGu DingTong ointment is effective in treating OA rats to a certain degrees, one of its mechanisms is inhibiting NO generation induced by IL-1β, hence to develop antioxidant functions and inhibit the apoptosis of synovial cells.

相似文献/References:

[1]田雪梅,张丽君,柳树英.中医外治法辨证治疗膝骨性关节炎120例[J].西部中医药,2012,25(10):95.
 TIAN Xue-mei,ZHANG Li-jun,LIU Shu-ying.Syndrome Differentiation of TCM External Treatment for 120 Cases of Knee Osteoarthritis[J].Western Journal of Traditional Chinese Medicine,2012,25(07):95.
[2]赵道洲,郑恒恒.手法配合陇中Ⅰ号汽雾透皮疗法治疗膝骨性关节炎的临床研究*[J].西部中医药,2013,26(04):36.
 ZHAO Daozhou,ZHENG Hengheng.Clinical Study on Manipulation and Gansu Mist Transdermal Therapy No.1 in Treating Knee Osteoarthritis[J].Western Journal of Traditional Chinese Medicine,2013,26(07):36.
[3]李兴勇,徐霞,麻虎,等.中医药治疗膝关节骨性关节炎的现状[J].西部中医药,2013,26(12):144.
 LI Xingyong,XU Xia,MA Hu,et al.Progress of Treatment for Knee Osteoarthritis by TCM[J].Western Journal of Traditional Chinese Medicine,2013,26(07):144.
[4]陆金金,欧阳八四.电针与温针灸治疗瘀血阻滞型膝骨关节炎的疗效比较[J].西部中医药,2014,27(04):119.
 LU Jinjin,OUYANG Basi.Comparison of Clinical Effects between Acusector and Warm Needling Moxibustion in Treating Knee Osteoarthritis of Blood Stasis Obstruction Pattern[J].Western Journal of Traditional Chinese Medicine,2014,27(07):119.
[5]李春娥,董建文,王文波.膝关节骨性关节炎熏洗方用药规律文献研究[J].西部中医药,2015,28(03):97.
[6]王想福,石瑞芳,武纪玲,等.玻璃酸钠单独使用与联合解毒消瘀膏治疗膝骨性关节炎疗效观察[J].西部中医药,2015,28(03):118.
[7]周天恒.针灸治疗膝骨性关节炎临床观察[J].西部中医药,2015,28(04):123.
[8]李宁,李应福,谢兴文,等.兰州地区膝关节骨性关节炎的中医证候分布特点[J].西部中医药,2016,29(02):95.
 LI Ning,LI Yingfu,XIE Xingwen,et al.Distribution Features of TCM Syndromes of Knee Osteoarthritis in Lanzhou City[J].Western Journal of Traditional Chinese Medicine,2016,29(07):95.
[9]姚兴璋,李兴勇,李喜香,等.骨痹止痛液对兔膝骨性关节炎软骨中相关因子表达影响的研究[J].西部中医药,2016,29(04):29.
 YAO Xingzhang,LI Xingyong,LI Xixiang,et al.Study on the Influence of GuBi ZhiTong Liquid on Cartilage-related Factors Expressions of the Rabbits with Knee Osteoarthritis[J].Western Journal of Traditional Chinese Medicine,2016,29(07):29.
[10]李莉红,孙士杰,张选平,等.耳针与灸法并用对膝骨性关节炎患者Lysholm评分及VAS积分的影响[J].西部中医药,2016,29(04):109.
 LI Lihong,SUN Shijie,ZHANG Xuanping,et al.Influence of Ear Acupuncture and Moxibustion on Lysholm Scales and VAS of the Patients with Knee Osteoarthritis[J].Western Journal of Traditional Chinese Medicine,2016,29(07):109.

备注/Memo

备注/Memo:
收稿日期:2015-06-25 *基金项目:甘肃省中医药管理局科研课题基金项目(编号GZK-2013-38)。 作者简介:陈小平(1971—),男,副主任医师。研究方向:风湿病、骨病的中医药研究与治疗。 △通讯作者:刘彩民(1956—),男,副主任医师。研究方向:风湿病、骨病的中医药研究与治疗。
更新日期/Last Update: 2016-07-15