[1]郭俊林,张志明△.丹红注射液治疗慢性脑供血不足的Meta分析[J].西部中医药,2016,29(07):76-80.
　GUO Junlin,ZHANG Zhiming.Meta Analysis of DanHong Injection in Treating Chronic Cerebral Blood Supply Insufficiency[J].Western Journal of Traditional Chinese Medicine,2016,29(07):76-80.
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丹红注射液治疗慢性脑供血不足的Meta分析
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
29
期数:
2016年07期
页码:
76-80
栏目:
出版日期:
2016-07-15

文章信息/Info

Title:
Meta Analysis of DanHong Injection in Treating Chronic Cerebral Blood Supply Insufficiency
文章编号:
1004-6852(2016)07-0076-05
作者:
郭俊林1，张志明2△
1 庆阳市人民医院神经内科，甘肃 庆阳 745000； 2 甘肃省中医药大学附属医院
Author(s):
GUO Junlin1, ZHANG Zhiming2△
1 Neurology Department of Qingyang Municipality People′s Hospital, Qingyang 745000, China;2 University Hospital of Gansu Traditional Chinese Medicine
关键词:
脑缺血; 椎基底动脉缺血; 丹红注射液; Meta分析
Keywords:
cerebral ischemia;  vertebrobasilar ischemia;  DanHong injection;  Meta analysis
分类号:
R276.8
文献标志码:
A
摘要:
目的：系统评价丹红注射液治疗慢性脑供血不足的有效性和安全性。方法：使用丹红注射液、脑供血不足等检索词系统检索中、英文数据库后，按照纳入和排除标准，筛选符合条件的随机对照试验，按系统评价手册评价纳入文献质量，并使用RevMan软件进行数据合并和分析。结果：纳入11项研究，共1 232例患者。Meta分析结果显示：试验组的临床疗效增高［OR=4.99，95%CI(3.29，7.58)］，同时椎基底动脉血流速度增大［SMD=0.92，95%CI(0.76，1.07)］，全血高［SMD=-0.96，95%CI(-1.53，-0.39)］、低切黏度［SMD=-0.49，95%CI(-0.79，-0.19)］和血浆比黏度减小［SMD=-0.69，95%CI(-1.14，-0.24)］，与未使用丹红注射液的对照组相比，差异均有统计学意义。在安全性方面，仅有3项研究报道8例患者出现了不适反应，2组比较差异无统计学意义(P＞0.05)。结论：基于目前证据，在常规治疗的基础上，加用丹红注射液治疗慢性脑供血不足，可进一步提高临床疗效，增加椎基底动脉的血流速度，改善血液的高黏滞状态，而不增加药物治疗相关不良反应的发生风险。
Abstract:
Objective: To systematically assess the effectiveness and the safety of DanHong injection in treating chronic cerebral blood supply insufficiency. Methods: DanHong injection, cerebral blood supply insufficiency and others were taken as the terms to search Cbase and English database, and RCTs meeting the requirements were chosen according to inclusion and exclusion standard, the quality of the included literature was assessed by system evaluation handbook, and data merging and analysis were performed by using RevMan software. Results: Altogether 11 studies were included and 1 232 patients involved. Meta analysis showed that: therapeutic effects［OR=4.99，95%CI(3.29，7.58)］of the experiment group increased, at the same time, blood flow rate of vertebral basilar artery ［SMD=0.92，95%CI(0.76，1.07)］increased, and whole blood high viscosity［SMD=-0.96,95%CI(-1.53，-0.39)］, low shear viscosity［SMD=-0.49，95%CI(-0.79，-0.19)］and plasma viscosity ［SMD=-0.69，95%(-1.14，-0.24)］reduced, there was significant difference compared with the control group without using DanHong injection. About the safety, there were only eight cases with adverse reaction in three reports, and the difference had no statistical meaning. Conclusion: Based on current evidence, conventional treatment combined with DanHong injection in treating chronic cerebral blood supply insufficiency could raise therapeutic effects, increase blood flow rate of vertebral basilar artery and improve high viscosity state of the blood, while not increase the incidence of drug-induced related adverse reaction.

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备注/Memo

备注/Memo:
收稿日期：2015-10-27 作者简介：郭俊林(1973—)，男，副主任医师。研究方向：心脑血管疾病的中西医结合治疗。 △通讯作者：张志明(1964—)，男，硕士研究生导师，主任医师。研究方向：急危重症疾病的中西医结合治疗。
更新日期/Last Update: 2016-07-15