[1]吴尚华,沈玉鹏,杨志华,等.自拟宣肺定喘汤对咳嗽变异性哮喘模型大鼠血清IFN-γ和IL-4水平的影响[J].西部中医药,2017,30(01):14-16.
　WU Shanghua,SHEN Yupeng,YANG Zhihua,et al.The Influences of Selfmade XuanFei DingChuan Tang on the Levels of Serum IFN-γ and IL-4 in Rat Model with Cough Variant Asthma[J].Western Journal of Traditional Chinese Medicine,2017,30(01):14-16.
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自拟宣肺定喘汤对咳嗽变异性哮喘模型大鼠血清IFN-γ和IL-4水平的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年01期
页码:
14-16
栏目:
出版日期:
2017-01-15

文章信息/Info

Title:
The Influences of Selfmade XuanFei DingChuan Tang on the Levels of Serum IFN-γ and IL-4 in Rat Model with Cough Variant Asthma
文章编号:
1004-6852(2017)01-0014-03
作者:
吴尚华1，沈玉鹏2，杨志华2，魏桂梅1
1 甘肃省中医院白银分院，甘肃 白银 730090； 2 甘肃省中医院
Author(s):
WU Shanghua1, SHEN Yupeng2, YANG Zhihua2, WEI Guimei1
1 Baiyin Branch of Gansu Provincial Hospital of TCM, Baiyin 730090, China; 2 Gansu Provincial Hospital of Traditional Chinese Medicine
关键词:
咳嗽变异性哮喘; 免疫调节; 宣肺定喘汤
Keywords:
CVA;  immune regulation;  XuanFei DingChuan Tang
分类号:
R289
文献标志码:
A
摘要:
目的:通过测定和分析实验大鼠外周血干扰素γ(IFN-γ)和白细胞介素4(IL-4)的含量，观察自拟宣肺定喘汤对咳嗽变异性哮喘大鼠免疫功能的影响，探讨复方中药对咳嗽变异性哮喘机体的免疫调节机制，为中药开发提供实验依据。方法：采用卵蛋白和氢氧化铝激发致敏并用卵蛋白激发的方法复制CVA模型大鼠，随机分为6组，各组间予以相应治疗3周后腹主动脉取血，检测血清IFN-γ、IL-4水平。结果：自拟宣肺定喘汤可明显提高CVA模型大鼠血清IFN-γ的水平，降低血清IL-4的水平。结论：自拟宣肺定喘汤能借助抑制细胞因子IFN-γ、IL-4的水平，降低机体抗原和特异性抗体交联，抑制或阻断咳嗽变异性哮喘的早期发病过程，具有抗气道炎症及免疫调节作用，可能是中药复方治疗CVA的机制之一。
Abstract:
Objective: To observe the influences of selfmade XuanFei DingChuan Tang on immune function of rats with cough variant asthma(CVA) and discuss immune regulation mechanism of compound Chinese medicine on CVA by measuring and analyzing levels of serum IFN-γ and IL-4 of peripheral blood in experimental rats, therefore, to provide experimental basis for TCM development. Methods: CVA rats model were duplicated by using OVA, sensitized and challenged aluminum hydroxide and challenged OA, they were randomly divided into six groups, blood of all groups were drawn from abdominal aorta after corresponding treatment of three weeks, levels of IFN-γ and IL-4 were detected. Results: Selfmade XuanFei DingChuan Tang can improve serum IFN-γ level of CVA rats model, lower the level of serum IL-4. Conclusion: Selfmade XuanFei DingChuan Tang can lower cross-link of body antigen and specific antibody by inhibiting levels of IFN-γ and IL-4 of cytokine to inhibit and stop early progress of CVA, which could resist airway inflammation and regulate immunity, it may be one of mechanisms of compound Chinese herbs in treating CVA.

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备注/Memo

备注/Memo:
收稿日期：2015-10-24 *基金项目：甘肃省中医药管理局科研课题(编号GZK-2014-30)。作者简介：吴尚华(1963—)，女，副主任医师。研究方向：常见病、多发病的中医诊治。
更新日期/Last Update: 2017-01-15