[1]张征,刘长明,薛冰.丹参注射液与黄芪注射液对脑梗死大鼠急性期神经功能和梗死面积的影响[J].西部中医药,2017,30(01):17-19.
　ZHANG Zheng,LIU Changming,XUE Bing.The Influences of DanShen Injection and HuangQi Injection on Neurological Function and Infarct Size of Rats with Cerebral Infarction at Acute Stage[J].Western Journal of Traditional Chinese Medicine,2017,30(01):17-19.
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丹参注射液与黄芪注射液对脑梗死大鼠急性期神经功能和梗死面积的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年01期
页码:
17-19
栏目:
出版日期:
2017-01-15

文章信息/Info

Title:
The Influences of DanShen Injection and HuangQi Injection on Neurological Function and Infarct Size of Rats with Cerebral Infarction at Acute Stage
文章编号:
1004-6852(2017)01-0017-03
作者:
张征，刘长明，薛冰
承德市食品药品检验检测中心，河北 承德 067000
Author(s):
ZHANG Zheng，LIU Changming，XUE Bing
Chengde Municipality Detection Center for Food and Drug，Chengde 067000，China
关键词:
脑梗死; 神经功能; 大鼠; 丹参注射液; 黄芪注射液
Keywords:
cerebral infarction;  neurological function;  rats;  DanShen injection;  HuangQi injection
分类号:
R743.3
文献标志码:
A
摘要:
目的：探讨丹参注射液与黄芪注射液对脑梗死大鼠急性期神经功能和梗死面积的影响。方法：将成年SD大鼠80只分为假手术组20只，模型组60只(对照组、研究组A及研究组B各20只)。对照组大鼠术后注射生理盐水，研究组A采用黄芪注射液治疗，1次/d，研究组B采用丹参注射液治疗，1次/d。计算术后1、2、3天及7天4组大鼠死亡率并比较各组大鼠神经功能缺损评分、脑梗死面积比及脑湿重比。结果：研究组A及研究组B大鼠脑梗死急性期的死亡率较对照组有所降低，研究组B效果更明显，与对照组比较差异具有统计学意义(P＜0.05)。研究组A及研究组B大鼠术后2、3天及7天神经功能缺损评分较对照组有所改善，研究组B改善效果更明显，与对照组比较差异具有统计学意义(P＜0.05)。研究组A及研究组B大鼠术后7天脑梗死面积较对照组有所下降，差异具有统计学意义(P＜0.05)。对照组大鼠术后7天脑湿重比高于假手术组及研究组A，差异具有统计学意义(P＜0.05)；研究组B与对照组比较差异无统计学意义(P＞0.05)。结论：丹参注射液治疗急性期脑梗死可有效改善大鼠神经功能，减少梗死面积及脑组织水肿状态。
Abstract:
Objective: To explore the influences of DanShen injection and HuangQi injection on neurological function and infarct size of rats with cerebral infarction at acute stage. Methods: All 80 adult SD rats were divided into sham operation group (20) and the model group (60)( the control group, the study group A and B, each 20). The control group was given injection of normal saline after surgery, the study group A was given HuangQi injection, once per time, the study group B was given DanShen injection, once per day. Death rate, NIHSS, area of cerebral infarction and brain wet ratio in four groups in one, two, three and seven days after surgery were compared. Results: Death rates of rats with cerebral infarction at acute stage in study group A and B decreased compared with the control group, the study group B had more obvious improvement, there was statistical difference compared with the control group(P＜0.05). NIHSS of rats in the study group A and B improved compared with that of the control group in two, three and seven days after surgery, but the study group was improved more obviously, there was statistical difference (P＜0.05). Brain wet ratio of rats in the control group in seven days after surgery was higher than that of sham operation and the study group A, there was statistical difference (P＜0.05); when the study group B was compared with the control group, there were no statistical differences(P＞0.05). Conclusion: DanShen injection in treating cerebral infarction in acute stage is accurate, it can improve neurological function of rats, reduce infarct size and edema of cerebral tissue.

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备注/Memo

备注/Memo:
收稿日期：2016-08-20 作者简介：张征(1984—)，女，主管药师。研究方向：药理学。
更新日期/Last Update: 2017-01-15