[1]李凯,王育良,张传伟.鬼针草治疗阿托品干眼兔模型的实验研究[J].西部中医药,2017,30(02):13-15.
 LI Kai,WANG Yuliang,ZHANG Chuanwei.Experimental study on Sticktight in Treating Atropine Dry Eye Rabbit Model[J].Western Journal of Traditional Chinese Medicine,2017,30(02):13-15.
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鬼针草治疗阿托品干眼兔模型的实验研究()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年02期
页码:
13-15
栏目:
方药·药理研究
出版日期:
2017-02-15

文章信息/Info

Title:
Experimental study on Sticktight in Treating Atropine Dry Eye Rabbit Model
文章编号:
1004-6852(2017)02-0013-03
作者:
李凯王育良张传伟
南京中医药大学附属医院,江苏 南京 210029
Author(s):
LI Kai, WANG Yuliang, ZHANG Chuanwei
The Affliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China
关键词:
鬼针草干眼炎症凋亡泪腺动物实验
Keywords:
sticktight dry eye inflammation apoptosis lacrimal gland rabbit amimal experiment
分类号:
R285.5
文献标志码:
A
摘要:
南京中医药大学附属医院,江苏 南京 210029
Abstract:
Objective: To explore the effects and function mechanism of sticktight in treating experimental dry eye. Methods: All 18 mature white rabbits from New Zealand were randomly divided into the normal control group, the model group, the sticktight treatment group, each group six rabbits. The model group and the sticktight treatment group were given atropine eye drops to establish dry eye model, the sticktight treatment group was given intragastric administration of sticktight, continuous medication for four weeks. Two and four weeks before and after experiment, fluorescein staining(FS) was measured, tear secretion was evaluated through ocular surface. IL-1, TNF-α, Fas and bcl-2 expressions in lacrimal gland were detected by IHC in the fourth week. Results: FS in the model group of two weeks was positive, after four weeks, positivity got more high, FS in the sticktight treatment group of two weeks was positive, but it was lower than the model group, positivity didn′t also get more high after four weeks; tear secretion in the model experimental group of two and four weeks was dcreased obviously compared with before(P<0.05); SIT in the sticktight treatment group was decrased obviously than before, but there was no statistical difference(P>0.05), compared with the model group, better than the model group obviously(P<0.05); Fas and IL-1protein expressions of epithelial cells in lacrimal glands in the sticktight treatment group were decreased compared with the model group, there were significant statistical differences(P<0.05). Conclusion: Sticktight can improve corneal epithelium damage and tear secretion of rabbit with dry eye, inhibit apoptosis and inflammation reaction of lacrimal glands tissue, and has protection function for lacrimal glands tissue of dry eye.

相似文献/References:

[1]丁宁,高卫萍△.类风湿性关节炎与干眼的相关性研究[J].西部中医药,2018,31(03):1.
 DING Ning,GAO Weiping.Study on the Correlation of Rheumatoid Arthritis with Xeroma[J].Western Journal of Traditional Chinese Medicine,2018,31(02):1.
[2]迟凯耀,赵磊,程相甫,等.左韬教授“调肝开玄”论治非老龄诱因干眼经验撷英[J].西部中医药,2022,35(12):84.[doi:10.12174/j.issn.2096-9600.2022.12.18]
 CHI Kaiyao,ZHAO Lei,CHENG Xiangfu,et al.Professor Zuo Tao′s Experience in Treating Dry Eye of Non-aging Causes by "Regulating Liver and Opening Sweat Pores"[J].Western Journal of Traditional Chinese Medicine,2022,35(02):84.[doi:10.12174/j.issn.2096-9600.2022.12.18]

备注/Memo

备注/Memo:
收稿日期:2016-11-21*基金项目:江苏省2014年省级自然科学基金(青年科技人才专项资金)面上项目(编号BK20141504);南京中医药大学附属医院2013年度院级课题博士项目(编号Y13030);江苏省“六大人才”高峰项目(编号2015-WSW-048);江苏省“十二五”中医药重点学科建设项目(编号js1304)。作者简介:李凯(1976—),男,博士学位,副主任医师。研究方向:眼表疾病的中西医结合诊治。
更新日期/Last Update: 2017-02-15