[1]李军山,陈钟,张肖建,等.木贼配方颗粒质量标准研究[J].西部中医药,2017,30(03):25-27.
　LI Junshan,CHEN Zhong,ZHANG Xiaojian,et al.Study on Quality Standard of MuZei Dispensing Granules[J].Western Journal of Traditional Chinese Medicine,2017,30(03):25-27.
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木贼配方颗粒质量标准研究()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年03期
页码:
25-27
栏目:
出版日期:
2017-03-15

文章信息/Info

Title:
Study on Quality Standard of MuZei Dispensing Granules
文章编号:
1004-6852(2017)03-0025-03
作者:
李军山，陈钟，张肖建，高晗，李振江
神威药业集团有限公司，河北 石家庄 051430
Author(s):
LI Junshan, CHEN Zhong, ZHANG Xiaojian, GAO Han, LI Zhenjiang
Shineway Pharmaceutical Group Limited Company, Shijiazhuang 051430, China
关键词:
木贼; 配方颗粒; 薄层色谱法; 高效液相色谱法; 质量标准
Keywords:
MuZei;  dispensing granules;  thin layer chromatography;  high performance liquid chromatography;  quality standard
分类号:
R285
文献标志码:
A
摘要:
目的：建立木贼配方颗粒质量标准。方法：采用TLC法对木贼配方颗粒进行鉴别;采用HPLC法对木贼配方颗粒中的山奈素进行测定，并对木贼配方颗粒相关指标进行检查。结果：TLC 方法中木贼配方颗粒在与木贼对照药材对应位置上，呈现相同颜色的斑点;山奈素的线性范围为0.040 48～0.404 8 μg(r=0.999 8)，平均回收率为98.44%(RSD=1.21%，n=9)。木贼配方颗粒水分、溶化性、粒度均达到药典颗粒剂的要求。结论：该方法简便、准确、重复性好，可用于木贼配方颗粒的质量控制。
Abstract:
Objective: To establish the quality standard of MuZei(Equisetum hiemale) dispensing granules. Methods: MuZei dispensing granules were discerned by TLC method; at the same time, the kaempferide from MuZei dispensing granules was measured by HPLC method, and the relevant indexes of MuZei dispensing granules were examined. Results: MuZei dispensing granules in TLC showed the same color spots at a position corresponding to the control medicine of MuZei; The linear range of kaempferol was 0.040 48～0.404 8 μg (r=0.999 8), and the average recovery rate was 98.44% (RSD=1.21%, n=9). The moisture, solubility, and particle size of MuZei dispensing granules all reached the requirements of Pharmacopoeia granules. Conclusion: This method is simple, accurate, reproducible, and can be used for quality control of MuZei dispensing granules.

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备注/Memo

备注/Memo:
收稿日期：2016-02-20 *基金项目：国家中医药管理局中医药科学技术研究专项课题(编号2013X07)；河北省科技计划项目(编号14272504D)。 作者简介：李军山(1965—)，男，正高级工程师。研究方向：药物工艺及质量标准研究。
更新日期/Last Update: 2017-03-15