[1]韦尼,薛智丰,朱跃兰△.活血解毒方对干燥综合征患者生活质量的影响[J].西部中医药,2017,30(04):5-9.
 WEI Ni,XUE Zhifeng,ZHU Yuelan.The Influence of HuoXue JieDu Prescription on Life Quality of SS Patients[J].Western Journal of Traditional Chinese Medicine,2017,30(04):5-9.
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活血解毒方对干燥综合征患者生活质量的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年04期
页码:
5-9
栏目:
出版日期:
2017-04-15

文章信息/Info

Title:
The Influence of HuoXue JieDu Prescription on Life Quality of SS Patients
文章编号:
1004-6852(2017)04-0005-05
作者:
韦尼1薛智丰2朱跃兰1△
1 北京中医药大学东方医院风湿科,北京 100078; 2 北京丰台区蒲黄榆社区卫生服务中心
Author(s):
WEI Ni1, XUE Zhifeng2, ZHU Yuelan1△
1 Rheumatism Department of Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078, China;2 PuHuangYu Community Health Service Center of FengTai District
关键词:
活血解毒方干燥综合征生活质量
Keywords:
HuoXue JieDu prescription sjogren’ s syndrome life quality
分类号:
R442.8
文献标志码:
A
摘要:
目的:观察活血解毒方对干燥综合征(SS)患者生活质量的影响。方法:将符合诊断标准的79例阴津亏虚,邪毒滞络型原发性干燥综合征(PSS)患者随机分为2组。观察组40例给予活血解毒方,1剂/d,早晚分2次口服;对照组39例给予白芍总苷胶囊0.6 g/次,3次/d。2组疗程均为12周。观察治疗前后2组患者中医症状积分以及血沉(ESR)、C反应蛋白(CRP)、免疫球蛋白、泪液分泌试验(Sit)、泪膜破碎时间测定(BUT)、静态唾液流率等实验室及物理检查指标,同时对简明健康状况调查问卷表(SF-36)、焦虑自评量表(SAS)、抑郁自评量表(SDS)进行评分。结果:总有效率2组比较,差异无统计学意义(P>0.05)。与治疗前相比,2组治疗后均可降低除腮部肿大外的中医症状积分,降低CRP、免疫球蛋白水平,增加泪液分泌量、静态唾液流率,并延长泪膜破碎时间,同时提高SF-36量表中SF、VT、MH维度评分及降低SAS评分,其中在降低口眼干积分、增加泪液分泌量、静态唾液流率、延长泪膜破碎时间以及提高VT维度评分及降低SAS评分方面,观察组优于对照组(P<0.05),观察组还可降低ESR水平及SDS评分,增加SF-36量表RE、RP维度评分(P<0.05)。结论:活血解毒方能有效治疗阴津亏虚邪毒滞络型原发性干燥综合征,可改善临床症状及相关实验室物理检查指标,提高患者生活质量。
Abstract:
Objective: To observe the effects of HuoXue JieDu prescription on life quality of the patients with sjogren’s syndrome (SS). Methods: All 79 primary SS (pSS) patients of Yin fluid deficiency, pathogen toxin ob structing collaterals pattern were randomized into two groups. The observation group took HuoXue JieDu prescription orally, one dose each day, taking in the morning and evening; the control group were given total glucosides of peony (TGP) capsules, 0.6g each time, three times per day. Both groups were treated for twelve weeks. TCM symptom scores, lab indexes and physical examination indexes including erythrocyte sedimentation rate (ESR), C reactive protein (CRP), immunoglobulin, Schirmer test (Sit), breakup time (BUT), static salivary flow rate and others were observed before and after treating, simultaneously, SF-36, SAS and SDS were scored. Results: The comparison of total effective rates of both groups had no statistical meaning (P>0.05). Compared with before treating, TCM symptom scores except cheek swelling, the level of CRP, immunoglobulin decreased, salivary secretion and static salivary flow rate increased, BUT prolonged, at the same time, SF, VT, MH dimensional scores in SF-36 scales increased, SAS scales decreased, the observation group was superior to the control group in decreasing the scores of dry mouth and eye, increasing shirmer, static salivary flow rate, prolonging BUT, raising VT dimensional scale and decreasing SAS scales (P<0.05), ESR level and SDS scales lowered, RE and RP dimensional scales in SF-36 increased (P<0.05). Conclusion: HuoXue JieDu prescription could effectively treat SS of Yin fluid deficiency, pathogen toxin obstructing collaterals pattern, it could improve clinical symptoms, related lab and physical examination indexes, improve life quality of the patients.

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备注/Memo

备注/Memo:
收稿日期:2016-11-20 作者简介:韦尼(1983—),男,博士学位,主治医师。研究方向:风湿免疫疾病的中医药防治。 △通讯作者:朱跃兰(1959—),女,博士学位,主任医师,教授。研究方向:风湿免疫疾病的中医药防治。
更新日期/Last Update: 2017-04-15