[1]李盛华,周明旺,潘文,等.野菊花对大骨节病大鼠TNF-α、IL-6、NO、NOS的影响[J].西部中医药,2017,30(12):6-9.
 LI Shenghua,ZHOU Mingwang,PAN Wen,et al.The Influence of Wild Chrysanthemum Flower on TNF-α, IL-6, NO and NOS of the Rats Suffering Kaschin-Beck Disease[J].Western Journal of Traditional Chinese Medicine,2017,30(12):6-9.
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野菊花对大骨节病大鼠TNF-α、IL-6、NO、NOS的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年12期
页码:
6-9
栏目:
方药·药理研究
出版日期:
2017-12-15

文章信息/Info

Title:
The Influence of Wild Chrysanthemum Flower on TNF-α, IL-6, NO and NOS of the Rats Suffering Kaschin-Beck Disease
文章编号:
1004-6852(2017)12-0006-04
作者:
李盛华1周明旺1潘文2颜春鲁3宋渊1付志斌1
1 甘肃省中医院,甘肃 兰州 730050; 2 甘肃省中医药研究院; 3 甘肃中医药大学
Author(s):
LI Shenghua1 ZHOU Mingwang1 PAN Wen2 YAN Chunlu3 SONG Yuan1 FU Zhibin1
1 Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China; 2 Gansu Provincial Academy of Chinese Medicine; 3 Gansu University of Traditional Chinese Medicine
关键词:
大骨节病T-2毒素野菊花
Keywords:
Kaschin-Beck disease T-2 toxin wild chrysanthemum flower
分类号:
R285.5
文献标志码:
A
摘要:
目的:观察野菊花对大骨节病大鼠肿瘤坏死因子α(TNF-α)、白介素6(IL-6)、一氧化氮(NO)、一氧化氮合成酶(NOS)的影响。方法:将50只SPF级SD大鼠分为5组,分别为空白组,模型组,野菊花高、中、低剂量组。将大鼠T-2毒素灌胃4周造成大骨节病模型,造模的同时给予相应药物灌胃治疗。给药1个月后所有动物统一处死,取血清、膝关节检测。结果:与空白对照组比较,模型组大鼠血清血清IL-6及TNF-α的含量、NO、NOS指数均升高,2组比较差异有统计学意义(P<0.05);与模型组比较,野菊花高、中、低剂量组TNF-α、IL-6、NO、NOS指数均降低,差异有统计学意义(P<0.05)。从大鼠膝关节软骨病理切片HE染色来看:与空白对照组比较,模型组大鼠软骨细胞破坏明显,染毒成功;与模型组比较,野菊花高、中、低剂量组大鼠软骨细胞有明显的修复。结论:野菊花对大骨节病大鼠有一定的治疗作用。
Abstract:
Objective: To observe the effects of wild chrysanthemum flower on TNF-α, IL-6, NO and NOS of the rats suffering Kaschin-Beck disease(KBD). Methods: Fifty SPF SD rats were allocated to five groups, and they were the blank group, the model group, high, moderate and low dosage groups of wild chrysanthemum flower. Rats were drenched of T-2 toxin for four weeks to establish KBDrat model, simultaneously they accepted intragastric administration of the corresponding medicines. Serum and knee joints of the rats were detected after they were medicated for one month and sacrificed. Results: Compared with blank control group, TNF-α, IL-6, NO and NOS of the rats in the model group raised, and the difference had statistical meaning (P<0.05); compared with the model group, TNF-α, IL-6, NO and NOS of the rats in high, moderate and low dosage groups of wild chrysanthemum flower lowered, and the difference showed statistical meaning (P<0.05). HE staining of pathological section of knee arthrodial cartilage of the rats showed that: compared with blank control group, cartilage cells of the rats in the model group damaged obviously, and successfully contamination; compared with the model group, cartilage cells of the rats in high, moderate and low dosage groups of wild chrysanthemum flower restored notably. Conclusion: Wild chrysanthemum flower could treat KBD rats to a certain degree.

相似文献/References:

[1]李翼哲,李庆兵,吉海春,等.“寒”在大骨节病病因病机中的作用[J].西部中医药,2011,24(11):16.

备注/Memo

备注/Memo:
收稿日期:2017-03-08 *基金项目:甘肃省卫生行业计划项目(编号GWGL2010-36);陇中正骨学术流派传承工作室建设项目(编号LP0128061)。 作者简介:李盛华(1959—),男,主任医师,教授、博士研究生导师,卫生部有突出贡献的中青年专家,国务院政府特殊津贴专家,中华骨伤名师,国家科技奖评审专家,国家自然科学基金评审专家,国家中医药管理局医师资格评审委员会评审专家,甘肃省优秀专家,甘肃省名中医,甘肃省领军人才(第一层次)。兼任中国中西医结合学会骨科微创专业委员会主任委员,中华中医药学会骨伤分会副主任委员,中国中医药研究促进会中医学术流派分会常务委员,中国医院协会中医医院分会常务委员,甘肃省中医药学会骨伤专业委员会主任委员,甘肃省中西医结合学会骨科微创专业委员会主任委员,甘肃省骨伤科临床医学中心主任,《中国中医骨伤科杂志》副主编,《西部中医药》杂志编委会副主任,《西部微创骨科》杂志主编,《中医正骨》《中国骨伤》杂志编委,甘肃陇中正骨学术流派传承工作室负责人。研究方向:中医药防治骨关节疾病。
更新日期/Last Update: 2017-12-15