[1]王晓萍,杜改焕,曹骅.中风膏对颈动脉粥样硬化患者血清炎性细胞因子及颈动脉内膜中层厚度的影响[J].西部中医药,2018,31(06):6-9.
 WANG Xiaoping,DU Gaihuan,CAO Hua.Effects of Stroke Ointment on Inflammatory Cytokines and Carotid intima-media Thickness of the Patients with Carotid Atherosclerosis[J].Western Journal of Traditional Chinese Medicine,2018,31(06):6-9.
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中风膏对颈动脉粥样硬化患者血清炎性细胞因子及颈动脉内膜中层厚度的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年06期
页码:
6-9
栏目:
论著·临床论著
出版日期:
2018-06-15

文章信息/Info

Title:
Effects of Stroke Ointment on Inflammatory Cytokines and Carotid intima-media Thickness of the Patients with Carotid Atherosclerosis
文章编号:
1004-6852(2018)06-0006-04
作者:
王晓萍杜改焕曹骅
甘肃省中医院,甘肃 兰州 730050
Author(s):
WANG Xiaoping DU Gaihuan CAO Hua
Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
关键词:
颈动脉粥样硬化中风膏阿托伐他汀钙炎性细胞因子
Keywords:
carotid atherosclerosis stroke ointment atorvastatin calcium inflammatory cytokines
分类号:
R255.2
文献标志码:
A
摘要:
目的:观察中风膏对颈动脉粥样硬化(CAS)患者血清肿瘤坏死因子α(TNF-α)、神经内血管内皮细胞黏附分子1(VCAM-1)和单核细胞趋化蛋白(MCP-1)表达水平及颈动脉内膜中层厚度(IMT)的影响。方法:将150例CAS患者随机分为中风膏组(中药组)、阿托伐他汀钙组(西药组)与中风膏联合阿托伐他汀钙组(联合组),每组50例,各组均给予常规基础治疗,3个月为1个疗程,连续观察2个疗程。观察各组干预前后血清TNF-α、MCP-1、VCAM-1及IMT的变化情况。结果:中药组、西药组、联合组TNF-α、MCP-1、VCAM-1表达水平明显下降(P<0.05),西药组与中药组比较,差异有统计学意义(P<0.05),联合组与西药组比较差异有统计学意义(P<0.05)。西药组、联合组IMT均显著改善差异有统计学意义(P<0.05);中药组能够下降IMT,但差异无统计学差异(P>0.05);联合组与西药组比较差异有统计学意义(P<0.05)。结论:中风膏通过抑制CAS患者血清炎性细胞因子的表达与释放,发挥保护血管内皮的作用。中风膏联合阿托伐他汀钙干预能够延缓颈动脉IMT增厚,提高临床治疗效果。
Abstract:
Objective: To observe the effects of stroke ointment on carotid intima- media thickness (IMT) and the expressions of MCP-1, VCAM-1 and TNF-α in the serum of the patients with carotid atherosclerosis (CAS). Methods: All 150 CAS patients were randomized into stroke ointment group (herb group), atorvastatin calcium group (western medicine group) and the combination group, 50 cases each group, different groups accepted conventional therapies, three months were one course, for two courses consecutively. The changes of MCP-1, VCAM-1 and TNF-α as well as IMT in different groups were observed before and after the intervention. Results: The expressions of TNF-α, MCP-1 and VCAM-1 in the herb group, western medicine group and the combination group descended notably(P<0.05), western medicine group was more significant than the herb group, and the difference had statistical meaning (P<0.05), the combination group was more significant than western medicine group, and the difference had statistical meaning(P<0.05). IMT improved in the western medicine group and the combination group significantly(P<0.05), IMT fell in the herb group, while there was no statistical difference(P>0.05); the combination group was more notable than western medicine group, and the difference had statistical meaning (P<0.05). Conclusion: Stroke ointment could play the roles of protecting blood vessel endothelium by inhibiting the expression and the release of inflammatory cytokines in the serum of CAS patients. When it is combined with atorvastatin calcium in the intervention, it could delay thickening of carotid IMT and raise therapeutic effects.

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备注/Memo

备注/Memo:
收稿日期:2018-02-27 *基金项目:甘肃省中医药管理局项目(编号GZK-2012-2)。 作者简介:王晓萍(1978—),女,副主任医师,博士学位。研究方向:中西医结合治疗脑血管疾病。
更新日期/Last Update: 2018-06-15