[1]刘育苗,杨晓强△.脂必泰联合阿托伐他汀钙对冠心病患者血脂的影响[J].西部中医药,2018,31(12):89-91.
 LIU Yumiao,YANG Xiaoqiang.The Effects of ZhiBiTai Capsules and Atorvastatin Calcium on Blood Lipid of CHD Patients[J].Western Journal of Traditional Chinese Medicine,2018,31(12):89-91.
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脂必泰联合阿托伐他汀钙对冠心病患者血脂的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年12期
页码:
89-91
栏目:
报道·衷中参西
出版日期:
2018-12-15

文章信息/Info

Title:
The Effects of ZhiBiTai Capsules and Atorvastatin Calcium on Blood Lipid of CHD Patients
文章编号:
1004-6852(2018)12-0089-03
作者:
刘育苗杨晓强△
杨凌示范区医院,陕西 杨凌 712100
Author(s):
LIU Yumiao YANG Xiaoqiang△
Yangling Demonstration Zone Hospital, Yangling 712100, China
关键词:
高脂血症冠心病脂必泰阿托伐他汀钙心肌营养因子1高敏C反应蛋白
Keywords:
hyperlipoidemia coronary heart disease ZhiBiTai atorvastatin calcium CT-1 hs-CRP
分类号:
R541.4
摘要:
目的:观察脂必泰联合阿托伐他汀钙对冠心病(CHD)患者血脂的影响。方法:将120例患者随机分为3组,每组40例:ZA-10组以脂必泰480 mg+阿托伐他汀钙10 mg治疗;A-20组以阿托伐他汀钙20 mg治疗;A-40组以阿托伐他汀钙40 mg治疗,3组均治疗8周。测量患者治疗前后总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)及载脂蛋白ApoA1、ApoB100、心肌营养因子1(CT-1)、高敏C-反应蛋白(hs-CRP)、肌酸激酶同工酶(CK-MB)水平,观察不良反应发生情况。结果:治疗后TC、TG、LDL、ApoB100水平3组均显著下降(P<0.05);TG、LDL、ApoB100水平ZA-10组显著低于A-20、A-40组(P<0.05);3组患者载脂蛋白ApoA1水平比较无明显差异(P>0.05)。血清CT-1和hs-CRP水平3组均显著下降(P<0.05);CK-MB水平下降不明显(P>0.05),hs-CRP水平ZA-10组与A-20、A-40组比较差异显著(P<0.05)。不良反应发生率ZA-10组为17.5%,A-20组为25.0%,A-40组为30.0%,ZA-10组与A-40组比较,差异有统计学意义(P<0.05)。结论:脂必泰和阿托伐他汀钙联用可显著降低冠心病患者的TC、TG、LDL、ApoB100、hs-CRP水平,可减少阿托伐他汀钙的用量,且不良反应较少。
Abstract:
Objective:To observe the effects of ZhiBiTai and atorvastatin calcium on blood lipid of the patients with coronary heart disease (CHD). Methods: All 120 patients were randomized into three groups, 40 cases each group: ZA-10 group were treated by ZhiBiTai capsules, 480mg and atorvastatin calcium, 10mg; A-20 group were given atorvastatin calcium, 20mg; A-40 group atorvastatin calcium, 40mg, three groups were treated for eight weeks. The levels of TC, TG, HDL and LDL ApoA1, ApoB100, cardiotrophin-1 (CT-1), high sensitivity C-reactive protein (hs-CRP) and CK-MB of the patients were detected before and after treating, the incidence of adverse reaction was observed. Results: After treating, the levels of TC, TG, LDL, ApoB100 of three groups lowered notably (P<0.05); ZA-10 group was lower than A-20 and A-40 groups notably in the levels of TG, LDL and ApoB100 (P<0.05); the obvious difference didn't existed in the comparison of the level of ApoA1 among three groups (P>0.05). The levels of CT-1 and hs-CRP of three groups decreased remarkably (P<0.05); the level of CK-MB decreased insignificantly (P>0.05), the difference was significant in the comparison of the levels of hs-CRP when ZA-10 group was compared with A-20 and A-40 groups (P<0.05). The incidences of adverse reaction of ZA-10 group, A-20 and A4- group were 17.5%, 25.0% and 30.0%, the difference had statistical meaning when ZA-10 group was compared with A-40 group (P<0.05). Conclusion: The combination of ZhiBiTai capsules and atorvastatin calcium could decrease the levels of TC, TG, LDL, ApoB100 and hs-CRP with minor adverse reaction, and reduce the dose of atorvastatin calcium.

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备注/Memo

备注/Memo:
收稿日期:2018-04-27 作者简介:刘育苗(1978—),女,主治医师。研究方向:心血管疾病的治疗。 △通讯作者:杨晓强(1977—),男,副主任医师。研究方向:心血管疾病的治疗。
更新日期/Last Update: 2018-12-15