[1]张伟,张振榆.丹参合剂联合四联疗法治疗慢性萎缩性胃炎伴幽门螺杆菌感染48例[J].西部中医药,2018,31(10):91-94.
 ZHANG Wei,ZHANG Zhenyu.Treating 48 Cases of Chronic Atrophic Gastritis Accompanying HP-infection by DanShen Mixture Joined with Quadruple Therapy[J].Western Journal of Traditional Chinese Medicine,2018,31(10):91-94.
点击复制

丹参合剂联合四联疗法治疗慢性萎缩性胃炎伴幽门螺杆菌感染48例()
分享到:

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年10期
页码:
91-94
栏目:
出版日期:
2018-10-15

文章信息/Info

Title:
Treating 48 Cases of Chronic Atrophic Gastritis Accompanying HP-infection by DanShen Mixture Joined with Quadruple Therapy
文章编号:
1004-6852(2018)10-0091-04
作者:
张伟张振榆
榆林市第二医院,陕西 榆林 719000
Author(s):
ZHANG Wei, ZHANG Zhenyu
Yulin Municipality the Second Hospital, Yulin 719000, China
关键词:
胃炎萎缩性慢性幽门螺杆菌丹参合剂四联疗法
Keywords:
gastritis atrophic chronic Hp DanShen mixture quadruple therapy
分类号:
R573.3+2
文献标志码:
B
摘要:
目的:观察丹参合剂联合四联疗法治疗慢性萎缩性胃炎伴幽门螺杆菌(Hp)感染的临床疗效。方法:将96例患者按照就诊先后顺序分为观察组和对照组,每组48例。对照组给予铋剂四联疗法治疗,观察组在此基础上加服丹参合剂,2组均连续治疗2周。对比2组Hp根除率、临床疗效、炎性因子[白细胞介素2(IL-2)、白细胞介素6(IL-6)及白细胞介素8(IL-8)]表达水平及不良反应发生情况。结果:Hp根除率观察组为93.75%(45/48),对照组为77.08%(37/48),2组比较差异有统计学意义(P<0.05)。显效率、总有效率观察组分别为61.42%、95.83%,对照组分别为33.33%、77.08%,2组比较差异均有统计学意义(P<0.05)。血清IL-2、IL-6、IL-8水平治疗前后2组组内比较,差异有统计学意义(P<0.05);治疗后2组组间比较差异也有统计学意义(P<0.05)。不良反应发生率观察组为8.33%,对照组为27.08%,2组比较差异有统计学意义(P<0.05)。结论:丹参合剂联合四联疗法治疗萎缩性胃炎伴Hp阳性疗效好,安全性高。
Abstract:
Objective: To observe clinical effects of DanShen mixture and quadruple therapy in treating chronic atrophic gastritis(CAG) accompanying helicobacter pylori(Hp)-infection. Methods: A total of 96 patients were allocated to the observation group and the control group according to visiting order, 48 cases each group. The control group were treated with quadruple therapy of bismuth agent, and the observation group took DanShen mixture simultaneously, both groups were treated for two weeks. The incidence of adverse reaction, the expressions of inflammatory factors(IL-8, IL-6 and IL-2), clinical effects, Hp eradication rate of the patients were compared between both groups. Results: Hp eradication rate of the observation group was 93.75% (45/48), higher than 77.08% (37/48) of the control group, and the difference was statistically significant in the comparisons between both groups (P<0.05). The effectual rate and total effective rate of the observation group were 61.42% and 95.83%, higher than 33.33% and 77.08% of the control group respectively, and there was a significant difference(P<0.05). The difference had statistical meaning in the comparisons of the levels of IL-2, IL-6 and IL-8 within two groups before and after treating (P<0.05); the difference had statistical meaning in the comparison between both groups after treating (P<0.05). The incidence of adverse reaction in the observation group was 8.33%, lower than 27.08% of the control group, and the difference was statistically significant (P<0.05). Conclusion: DanShen mixture and quadruple therapy could obtain good effects in treating CAG accompanying Hp-infection with high safety.

相似文献/References:

[1]陈燕云,指导:王自立.中医药治疗慢性萎缩性胃炎的研究进展[J].西部中医药,2013,26(04):123.
 CHEN Yanyun Director: WANG Zili.Research Progress on the Treatment of Chronic Atrophic Gastritis with TCM[J].Western Journal of Traditional Chinese Medicine,2013,26(10):123.
[2]唐大军.中医分阶段治疗慢性胃炎幽门螺杆菌阳性患者30例[J].西部中医药,2013,26(09):66.
 TANG Dajun.TCM Treatment for 30 Patients Suffering from Chronic Gastritis Complicated with Positive Helicobacter Pylori at Different Stages[J].Western Journal of Traditional Chinese Medicine,2013,26(10):66.
[3]董莉莉,王军燕,刘安国,等.针灸治疗急性胃炎的临床选穴规律研究*[J].西部中医药,2013,26(11):129.
 DONG Lili,WANG Junyan,LIU Anguo,et al.Study on Acupoint Selection for Treating Acute Gastritis with Acupuncture[J].Western Journal of Traditional Chinese Medicine,2013,26(10):129.
[4]写国斌,武海燕.中西医结合治疗幽门螺旋杆菌感染胃炎97例[J].西部中医药,2013,26(12):101.
 XIE Guobin,WU Haiyan.Treating 97 Cases of Hp-infected Gastritis by Integrative Medicine[J].Western Journal of Traditional Chinese Medicine,2013,26(10):101.
[5]潘继波.枳术汤加味治疗胆汁反流性胃炎60例[J].西部中医药,2013,26(10):96.
 PAN Jibo.Modified ZhiZhuTang in Treating 60 Cases of Bile Reflux Gastritis[J].Western Journal of Traditional Chinese Medicine,2013,26(10):96.
[6]李镇,郑亮△.“治中焦如衡”在慢性胃炎治疗中的意义[J].西部中医药,2014,27(03):98.
 LI Zhen,ZHENG Liang.Analysis of the Meaning of "Treating Middle Energizer by Achieving Relative Equilibrium" in the Therapy Against Chronic Gastritis[J].Western Journal of Traditional Chinese Medicine,2014,27(10):98.
[7]余钦,指导:徐进康.慢性浅表性胃炎肝胃不和证中药用药频次统计[J].西部中医药,2014,27(04):66.
 YU Qin Director: XU Jinkang.TCM Medication Frequency Statistics for the Patients with Chronic Superficial Gastritis of Liver-stomach Disharmony Pattern[J].Western Journal of Traditional Chinese Medicine,2014,27(10):66.
[8]石天玙.清胃化湿汤治疗慢性胃炎 31 例[J].西部中医药,2014,27(08):65.
[9]刘启泉,王志坤△,李博林.达立通联合三联杀菌疗法根除慢性胃炎幽门螺旋杆菌感染的临床观察[J].西部中医药,2014,27(12):91.
[10]吴萌,万生芳△,王秋兰,等.中西医结合治疗慢性胃炎的Meta分析[J].西部中医药,2015,28(03):75.
[11]尤海鹰.制萎煎治疗脾胃虚弱型慢性萎缩性胃炎40例[J].西部中医药,2013,26(03):84.
 YOU Haiying.ZhiWeiJian in Treating 40 Cases of Chronic Atrophic Gastritis of Spleen-stomach Deficiency Pattern[J].Western Journal of Traditional Chinese Medicine,2013,26(10):84.
[12]马继利.中西药物联用治疗慢性萎缩性胃炎58例[J].西部中医药,2013,26(06):91.
 MA Jili.Treatment for 58 Cases of Chronic Atrophic Gastritis with Integrative Medicines[J].Western Journal of Traditional Chinese Medicine,2013,26(10):91.
[13]李耿.摩罗丹联合维生素B12治疗慢性萎缩性胃炎伴异型增生的临床观察[J].西部中医药,2012,25(07):11.
 LI Geng.Clinical Observation on MoLuoDan and Vitamin B12 in the Treatment of Chronic Atrophic Gastritis and Dysplasia[J].Western Journal of Traditional Chinese Medicine,2012,25(10):11.
[14]孙国荣,权亚喜.摩罗丹联合维生素B12治疗慢性萎缩性胃炎56例[J].西部中医药,2013,26(09):84.
 SUN Guorong,QUAN Yaxi.MoLuoDan and Vitamin B12 for 56 Patients Suffering from Chronic Atrophic Gastritis[J].Western Journal of Traditional Chinese Medicine,2013,26(10):84.
[15]刘晓燕,王四兵,程秋实,等.中医药治疗慢性萎缩性胃炎临床研究进展[J].西部中医药,2013,26(12):147.
 LIU Xiaoyan,WANG Sibin,CHENG Qiushi,et al.Clinical Study Progress of TCM in Treating Chronic Atrophic Gastritis[J].Western Journal of Traditional Chinese Medicine,2013,26(10):147.
[16]李竞,李初谊,王煜.王自立教授治疗肝郁脾弱型慢性萎缩性胃炎经验举隅[J].西部中医药,2014,27(03):53.
 LI Jing,LI Chuyi,WANG Yu.Professor Wang Zili′s Experience on Treating Chronic Atrophic Gastritis of Liver Depression and Spleen Deficiency Pattern[J].Western Journal of Traditional Chinese Medicine,2014,27(10):53.
[17]巩小丽,张菡△,严艳.枳实消痞丸化裁治疗慢性萎缩性胃炎60例[J].西部中医药,2014,27(10):100.
[18]党民卿,指导:王道坤.王道坤教授治疗慢性萎缩性胃炎癌前病变的经验[J].西部中医药,2015,28(02):37.
[19]彭海平,保继琼,赵敏,等.加味半夏泻心汤治疗幽门螺杆菌相关性萎缩性胃炎32例[J].西部中医药,2015,28(02):94.
[20]刘开发.一贯煎合麦门冬汤治疗慢性萎缩性胃炎42例[J].西部中医药,2015,28(08):82.

备注/Memo

备注/Memo:
收稿日期:2018-03-15 作者简介:张伟(1981—),男,主治医师。研究方向:内科疾病的中医诊治。
更新日期/Last Update: 2018-08-15