[1]葛红娣,刘秀艳,翟力军.小柴胡汤加减对肾病综合征血清IGF-1及结合蛋白的影响[J].西部中医药,2019,32(04):1-4.
　GE Hongdi,LIU Xiuyan,ZHAI Lijun.Impact of Modified XiaoChaiHu Decoction on IGF-1 and Its Binding Protein in Nephrotic Syndrome[J].Western Journal of Traditional Chinese Medicine,2019,32(04):1-4.
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小柴胡汤加减对肾病综合征血清IGF-1及结合蛋白的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
32
期数:
2019年04期
页码:
1-4
栏目:
出版日期:
2019-04-15

文章信息/Info

Title:
Impact of Modified XiaoChaiHu Decoction on IGF-1 and Its Binding Protein in Nephrotic Syndrome
文章编号:
1004-6852(2019)04-0001-04
作者:
葛红娣，刘秀艳，翟力军
遵化市人民医院，河北 遵化 064200
Author(s):
GE Hongdi, LIU Xiuyan, ZHAI Lijun
Zunhua Municipal People′s Hospital, Zunhua 064200, China
关键词:
肾病综合征; 小柴胡汤; 血清IGF-1; IGF-1结合蛋白; 免疫炎症反应
Keywords:
nephrotic syndrome;  XiaoChaiHu decoction;  serum IGF-1;  IGF-1 binding protein;  immune inflammatory reactions
分类号:
R692
文献标志码:
A
摘要:
目的：探讨小柴胡汤加减对肾病综合征血清胰岛素生长因子(IGF-1)及结合蛋白的影响。方法：将70例患者随机分为对照组和观察组，每组35例，对照组采用泼尼松片+环磷酰胺治疗；观察组在对照组治疗基础上采用小柴胡汤加减治疗，2组均治疗4个疗程，3个月为1个疗程，治疗前后测定血清(IGF-1)、胰岛素生长因子结合蛋白(IGFBPs)、T淋巴细胞亚群、白介素6(IL-6)、肿瘤坏死因子α(TNF-α)以及肾功能水平，记录24小时尿蛋白定量，同时对比临床疗效及不良反应状况。结果：与治疗前比较，2组治疗后血清IGF-1水平降低，血清IGFBPs水平升高，治疗后血清CD3+、CD4+水平升高，血清CD8+、IL-6、TNF-α水平降低，治疗后尿素氮(BUN)、肌酐(Scr)、24小时尿蛋白定量(24 hPro)水平降低，白蛋白水平升高(P＜0.05)；与对照组比较，观察组治疗后血清IGF-1水平较低，血清IGFBPs水平较高，治疗后血清CD3+、CD4+水平较高，血清CD8+、IL-6、TNF-α水平较低，治疗后尿素氮(BUN)、肌酐(Scr)、24小时尿蛋白定量(24 hPro)水平较低，白蛋白水平较高(P＜0.05)；对照组有效率71.43%低于观察组有效率91.43%(P＜0.05)；2组间总不良反应率对比差异无统计学意义(P＞0.05)。结论：小柴胡汤加减对肾病综合征患者治疗效果确切，提高胰岛素生长因子水平和免疫炎症反应，改善肾功能，且不增加药物的不良反应。
Abstract:
Objective：To discuss the effects of modified XiaoChaiHu decoction on IGF-1 and binding protein in nephrotic syndrome(NS). Methods: Seventy patients were randomly allocated to the control group and the observation group, 35 cases each group, the control group adopted prednison and cyclophosphamide; the observation group took modified XiaoChaiHu decoction based on the therapy the control group accepted, both groups were treated for four courses, three months were one course, to detect renal function, the levels of TNF-α, IL-6, T lymphocyte subsets, IGFBPs and IGF-1 before and after treating, to record 24 hours urinary protein quantification to compare, the incidence of adverse reaction and clinical effects simultaneously. Results: Compared with before treating, the level of IGF-1 lowered, the levels of IGFBPs rose, the levels of CD3+ and CD4+ increased after treating, the levels of CD8+, IL-6 and TNF-α decreased, the levels of BUN, Scr and 24hPro decreased while the levels of albumin enhanced in both groups (P＜0.05); compared with the control group, the level of IGF-1 in the observation group was lower, the levels of IGFBPs was higher, the levels of CD3+ and CD4+ were higher, while the levels of CD8+, IL-6 and TNF-α lowered, and the levels of BUN, Scr and 24hPro decreased, the level of albumin increased(P＜0.05); the effective rate of the control group was 71.43%, lower than 91.43% of the observation group(P＜0.05); no statistical difference has been found in total incidences of adverse reaction between both groups(P＞0.05). Conclusion: Modified XiaoChaiHu decoction could gain definite effects in treating NS patients, remarkably improve the level of insulin like growth factor and immune inflammatory reaction, renal function and not increase adverse reactions of the drugs.

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备注/Memo

备注/Memo:
收稿日期：2018-04-20 *基金项目：河北省科技厅项目(编号20151783)。 作者简介：葛红娣(1976—)，女，主治医师。研究方向：肾脏疾病的诊治。
更新日期/Last Update: 2019-04-15