[1]王炜,常卓,古玥儒,等.补肾活血法治疗抗心磷脂抗体阳性复发性流产的Meta分析[J].西部中医药,2019,32(04):81-87.
　WAGN Wei,CHANG Zhuo,GU Yueru,et al.Meta Analysis of Treating Positive-ACA Recurrent Spontaneous Abortion by the Method of Invigorating-kidney and Promoting Blood-circulation[J].Western Journal of Traditional Chinese Medicine,2019,32(04):81-87.
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补肾活血法治疗抗心磷脂抗体阳性复发性流产的Meta分析
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
32
期数:
2019年04期
页码:
81-87
栏目:
出版日期:
2019-04-15

文章信息/Info

Title:
Meta Analysis of Treating Positive-ACA Recurrent Spontaneous Abortion by the Method of Invigorating-kidney and Promoting Blood-circulation
文章编号:
1004-6852(2019)04-0081-07
作者:
王炜1，常卓1，古玥儒2，冯晓玲1△
1 黑龙江中医药大学附属第一医院，黑龙江 哈尔滨 150040; 2 黑龙江中医药大学附属第二医院
Author(s):
WAGN Wei1, CHANG Zhuo1, GU Yueru2, FENG Xiaoling1△
1 The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China; 2 The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine
关键词:
补肾活血法; 抗心磷脂抗体; 复发性流产; Meta分析
Keywords:
invigorating-kidney and promoting blood-circulation method;  anticardiolipin antibody;  recurrent spontaneous abortion;  Meta analysis
分类号:
R714.21
文献标志码:
A
摘要:
目的：运用循证医学的方法系统评价补肾活血法治疗抗心磷脂抗体(ACA)阳性复发性流产的疗效与安全性，为临床提供循证参考。方法：计算机检索国内外数据库及手动检索国内核心期刊(检索期限为1990年1月至2018年4月)，纳入以补肾活血法为组方依据治疗抗心磷脂抗体阳性复发性流产的临床随机对照试验，提取资料，用Cochrane系统评价的方法对文献质量进行评分，采用RevMan 5.3统计软件对纳入研究的结果进行Meta分析。结果：13篇相关研究文献被纳入本研究，Meta分析显示，与对照组相比，治疗组疗效总有效率增加，差异具有统计学意义［OR=3.77，95%CI(2.42，5.90)］；治疗组中医证候积分明显高于对照组，差异具有统计学意义［MD=-5.45，95%CI(-5.92，-4.99)］；治疗组ACA转阴率明显高于对照组，差异具有统计学意义［OR=3.71，95%CI(2.54，5.43)］；治疗组ACA水平明显低于对照组，差异具有统计学意义［MD=-1.99，95%CI(-2.31，-1.66)］；治疗组保胎至12周成功率明显高于对照组，差异具有统计学意义［OR=3.36，95%CI(2.14,5.28)］；治疗组血清人绒毛膜促性腺激素(β-HCG)明显高于对照组，差异具有统计学意义［MD=35.96，95%CI(33.20，38.71)］。结论：现有临床文献所评价补肾活血法治疗抗心磷脂抗体阳性复发性流产较西医有显著优势，是一种很有前景的治疗手段。
Abstract:
Objective: To provide evidence-based reference for clinical work by assessing clinical effects and the safety of invigorating-kidney and promoting blood-circulation method in the treatment for positive anticardiolipin antibody (ACA) recurrent spontaneous abortion(RSA) using the method of evidence-based medicine. Methods: Clinical randomized control test for the recipe based on the method of invigorating-kidney and promoting blood-circulation in the treatment for positive-ACA RSA were searched in domestic and foreign databases by computer and domestic core journals manually (retrieval period from January, 1990 to April, 2018) to extract the data, the quality of the papers were scored using Cochrane system evaluation method, the results of the included studies were performed Meta analysis using statistical software RevMan 5.3. Results: All 13 papers about the related studies were included in the study. Meta analysis showed that, compared with the control group, total effective rate of clinical effects in the treatment group raised, and the difference had statistical meaning ［OR=3.77, 95%CI(2.42,5.90)］; the treatment group was higher than the control group in TCM syndrome scores obviously, and the difference showed statistical meaning ［MD=-5.45, 95%CI(-5.92, -4.99)］; the treatment group was notably higher than the control group in ACA negative-conversion rate, and there was a significant difference ［OR=3.71, 95%CI(2.54, 5.43)］; the treatment group was lower than the control group in the levels of ACA obviously, and the difference was statistically significant ［MD=1.99, 95%CI(-2.31, -1.66)］; the treatment group was higher than the control group in the success rate of protecting the fetus to 12th week, and the difference had statistical meaning ［OR=3.36, 95%CI(2.14, 5.28)］; the treatment group was notably higher than the control group in β-HCG, and the difference had statistical meaning［MD=35.96, 95%CI(33.20, 38.71)］. Conclusion: The method of invigorating-kidney and promoting blood-circulation in the treatment for positive ACA RSA shows the distinct advantages compared with Western medicine assessed by the existing clinical literature, and it′s a promising therapeutic measure.

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备注/Memo

备注/Memo:
收稿日期：2018-04-14 *基金项目：国家自然科学基金资助项目(编号81373673，81574014）。 作者简介：王炜(1987—)，女，主治医师。研究方向：复发性流产、PCOS的诊治。 △通讯作者：冯晓玲(1969—)，女，主任医师。研究方向：复发性流产、子宫内膜异位症、不孕症、妇科肿瘤、外阴白色病变、女性盆腔炎性疾病的诊治。
更新日期/Last Update: 2019-04-15